查询词典 protein factor

Objective To explore livin, MTA1 and the caspase3 protein expression, their correlation and clinical pathology in colon cancer Methods The expressions of livin, MTA1 and caspase3 protein in 88 cases of colon cancer were detected by immunohistochemistry stainingResults Livin, caspase3 protein and MTA1 positive expression rates in colon cancer tissues were more than those in tissues beside the cancer Furthermore there were obvious relevance between livin protein, MTA1 positive expression rate and degree of histodifferentiation and lymph node metabasis and between caspase3 protein positive expression rate and degree of histodifferentiation of colon cancer Caspase3 protein expression had prominent inverse correlation with the livin expressionConclusions ①Over expression of livin having inhibtion on colon cancer is one of important factors of colon carcinogenesis ②Caspase3 protein expression in colon cancer tissues is inhibited to less and has prominent inverse correlation with livin expression Accordingly, suppressing caspase3 protein activity is one of channels, by which livin promotes colon carcinogenesis ③MTA1 plays the important role in histodifferentiation degree and lymph node metastasis of colon cancer

采用免疫组织化学染色方法检测88例结肠癌组织中Livin，Caspase3 及MTA1的表达情况。结果（1）结肠癌组织中Livin的阳性表达率显著高于癌旁组织，且Livin的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。（2）结肠癌组织中Caspase3蛋白的阳性表达率显著高于癌旁组织，且Caspase3蛋白的表达与结肠癌的组织分化程度显著相关。（3）结肠癌组织中MTA1的阳性表达率显著高于癌旁组织，且MTA1的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。（4）Caspase3蛋白的表达又与Livin的表达呈显著负相关。结论（1）Livin在结肠癌组织中过表达，它可能是促进结肠癌发生的重要因素之一。（2）Caspase3蛋白在结肠癌组织中表达被抑制而降低，且与Livin的表达呈负相关。因此，抑制Caspase3蛋白的活性是Livin促进结肠癌发生的途径之一。（3）MTA1对结肠癌的组织分化及淋巴转移发挥重要作用。

The products that we have been developed are: intermediate include Protoporphyrin,, protein peptone, plant peptone; Flavor material include hydrolyzed vegetable protein, meat flavor protein powder; food material include compound amino acid powder, soybean peptide,soybean polypeptide,blood peptide, collagen polypeptide, fish protein powder and hydrolyzed animal protein; protein powder include hydrolyzed soybean protein, hemoglobin,hemocrystallin and food-grade whey protein.

目前的已经开发的产品有医药中间体：原卟啉、卟啉铁、蛋白胨、植物蛋白胨；调味品原料：水解植物蛋白粉、肉味蛋白粉；食品原料：复合氨基酸、甘氨酸、大豆缩氨酸、大豆多肽、血肽、胶原多肽、鱼蛋白粉、水解动物蛋白粉和蛋白质粉系列产品：饮料专用型蛋白质粉、血红蛋白质粉、肉制品专用型蛋白质粉。进口的产品有乳清蛋白粉。

Nineteen spots were changed significantly after FA treatment.Thirteen proteins were identified by peptide mass fingerprinting or peptide sequence analysis,including putative nucleoside diphosphate kinase,elongation factor 1-gamma,triosephosphate isomerase,60S acidic ribosomal protein P0,heat shock protein 75 kDa,similar to heat shock 70kD protein binding protein,annexin I,hypothetical protein FLJ34423,microtubule-actin crosslinking factor 1,lamin B2,ATP synthase alpha chain,mitochondrial precursor,proteasome subunit alpha type 6.These identified proteins involved in energy metabolism,translation and RNA processing,protein folding,redox regulation,cell structure and cell signaling.

双向凝胶电泳结果显示，甲醛刺激后19个蛋白斑点发生变化，肽指纹图谱及肽序列标签鉴定了其中13个蛋白斑点，已鉴定的蛋白包括二磷酸核苷酸激酶、延长因子1-γ，磷酸丙糖异构酶、60S酸性核糖体蛋白P0、75kDa热休克蛋白、70kD热休克蛋白样结合蛋白、钙依靠磷脂结合蛋白I、假想蛋白FLJ34423、微管-肌动蛋白交叉连接因子1、核纤层蛋白B2、ATP合成酶α链、蛋白酶体α亚基6，这些蛋白功能涉及转录调节、蛋白折叠、信号传导、能量代谢、细胞骨架等各个方面。

Thirteen proteins were identified by peptide mass fingerprinting or peptide sequence analysis,including putative nucleoside diphosphate kinase,elongation factor 1-gamma,triosephosphate isomerase,60S acidic ribosomal protein P0,heat shock protein 75 kDa,similar to heat shock 70kD protein binding protein,annexin I,hypothetical protein FLJ34423,microtubule-actin crosslinking factor 1,lamin B2,ATP synthase alpha chain,mitochondrial precursor,proteasome subunit alpha type 6.These identified proteins involved in energy metabolism,translation and RNA processing,protein folding,redox regulation,cell structure and cell signaling.

双向凝胶电泳结果显示，甲醛刺激后19个蛋白斑点发生变化，肽指纹图谱及肽序列标签鉴定了其中13个蛋白斑点，已鉴定的蛋白包括二磷酸核苷酸激酶、延长因子1-γ，磷酸丙糖异构酶、60S酸性核糖体蛋白P0、75kDa热休克蛋白、70kD热休克蛋白样结合蛋白、钙依赖磷脂结合蛋白I、假想蛋白FLJ34423、微管-肌动蛋白交叉连接因子1、核纤层蛋白B2、ATP合成酶α链、蛋白酶体α亚基6，这些蛋白功能涉及转录调节、蛋白折叠、信号传导、能量代谢、细胞骨架等各个方面。

Farther apply FactorAnalysis, principle of pick-up is latent root＞1, using Varemax and Equamax to rotatefactor. We get 10 factors, combined with medical knowledge, based above result,clinical manifestation of sub-health status can split into 7 types, such as typesociety(Factor 6), type psychology(Factor 1), type fatigue(Factor 3,Factor 4,Factor 9),type discomfort of eye and mouth(Factor 7), type abnormity of stool and urine(Factor2), type menoxenia(Factor 5) and type consticution(Factor 8 and Fator 10). Thisprovide basis for classification, prevention and cure of sub-health status.

进一步应用因子分析，以特征根大于1为公因子提取原则，应用最大方差正交旋转法进行因子旋转，共得到十个共因子，结合医学知识，根据上述结果亚健康状态的临床表现可分为社会型(公因子6)、心理型(公因子1)、疲劳型公因子3、公因子4(来源：23ABC论文网www.abclunwen.com和公因子9、眼口不适型(公因子7)、二便异常型(公因子2)、月经不调型(公因子5)以及体质型(公因子8和公因子10)等七个亚型。

Along with the fluconazole solution density rise,the experimental two kind of strain various glucose density is higher,showe d the glucose consumption are less,takes the logarithmof the medicine de nsity,discovered the logarithm the medicine density and each glucose den sity presents the linear relations;Carries on the analysis comparison to under the fluconazole function two kind of strain linear relations,disc overed the relations of the two strains has the nonuniformity.3 Compare the fluconazole induction reaiatance SC5314 strain and sens itive strain compares,its difference gene expression mainly concentrates in:The code proteinase body and the protein hydroltyic enzyme gene,in the code sugar fat metabolism process is connected the protein gene,the cell cycle correlation gene,the duplication and the translation adjustme nt correlation gene,the stress response correlation gene,the line plast ochondria correlation gene,the cell wall function related gene.4 Candida albicans SC5314 induction resiatance strain was processed b y Xianglian solution,its expression change gene mainly is:Code stress re sponse family protein gene,biomembrane relevant gene,a code proteinase body gene race,code cell cycle related protein gene,duplication and tra nslation adjustment related protein gene.5 The clinical reaiatance strain Candida albicans was processed by Xi anglian solution,its expression change gene mainly is:Codes the hot sho ck protein gene,the serine/threonine protein activating enzyme gene,the proteinase body family gene,the regulation copies and translates the ge ne.

随着氟康唑药液的浓度上升，试验的两种菌株各孔葡萄糖浓度越高，说明葡萄糖消耗越少，经过药物浓度取对数后进行分析，发现取对数后的药物浓度和每孔中葡萄糖浓度者呈现线性关系；对氟康唑作用下的两种菌株的线性关系进行分析比较，发现对两种菌株作用具有不一致性。3氟康唑诱导的耐药SC5314菌株与诱导前的敏感株相比，其差异基因表达主要集中在：编码蛋白酶体及蛋白水解酶的基因，编码糖脂代谢过程中相关蛋白的基因，细胞周期相关基因，转录及翻译调节相关基因，应激反应相关基因，线粒体相关基因，细胞壁功能相关基因。4白念珠菌SC5314诱导耐药株经香莲外洗液作用后，其表达变化的基因主要是：编码应激反应家族蛋白的基因，生物膜相关性基因，编码蛋白酶体基因一族，编码细胞周期相关蛋白基因，转录及翻译调节的相关蛋白基因。5白念珠菌临床耐药菌株经香莲外洗液作用后，其表达变化的基因主要是：编码热休克蛋白基因，丝氨酸/苏氨酸蛋白激酶基因，蛋白酶体家族基因，调控转录及翻译基因。

Eggs and soyabean milk contains soap protein enzyme stayer,which can control liveness of flesh's protein enzyme,affecting protein digestion and absorption internal to the body.Egg white contains tough protein,which can integrate with soap protein enzyme in the soybean milk,blocking the break down of protein,thereby reducing the protein absorptivity of the body.

鸡蛋与豆浆生豆浆中含有胰蛋白酶抑制物，它能抑制人体蛋白酶的活性，影响蛋白质在人体内的消化和吸收，鸡蛋的蛋清里含有粘性蛋白，可以同豆浆中的胰蛋白酶结合，使蛋白质的分解受到阻碍，从而降低人体对蛋白质的吸收率。

First we first establish the apoptosis of related protein glossary database, then downloads the neurodegenerative disorders of apoptosis related abstract from the on-line biomedicine literature , and searchesfor the protein information database of the neurodegenerative disorders of apoptosis related pathway, then uses the data mining technology,with apoptosis of protein related glossary database use already establishment. Automatically searches for the neurodegenerative disorders of apoptosis related protein by the program in the biomedicine literature abstract separately in,(1) a sentence,(2) two sentences,(3) aliterature, finding simultaneously appears protein-protein interation. And comparing to the neurodegenerative disorders of apoptosis related protein database, looking for their repetition. This result comparing to the known neurodegenerative disorders of apoptosis related pathway, thus looking for unestablished neurodegenerative disorders of apoptosis pathway.

首先我们先建立细胞凋亡讯息蛋白质相关词汇字库，再从线上生物医学文献下载神经退化性疾病细胞凋亡相关文献摘要，并且搜寻线上蛋白质资料库中神经退化性疾病之细胞凋亡讯息蛋白质传递路径，接著利用文献探勘技术，使用已建立之细胞凋亡讯息蛋白质相关词汇字库，以程式自动在生物医学文献摘要中搜寻神经退化性疾病细胞凋亡相关蛋白质分别在，（1）一个句子、（2）二个句子、（3）一篇文献，中同时出现的两两蛋白质关系，再与已知线上神经退化性疾病细胞凋亡讯息传递路径资料库的蛋白质两两关系做比较，找出两者重复建立的部分，把这个结果与线上已知之细胞凋亡讯息传递路径资料库蛋白质关系作比较，由此找出尚未建立之细胞凋亡讯息传递路径图。

The identification of protein were performed by searching the mass spectrometry data from the NCBInr database using the software of Sequest Bioworks3. 2. The results indicated that over 25 protein components including acid and basis phospholipase A2, nerve growth factor, presynaptic neurotoxin, hemorrhagic factor, thrombin-like enzyme, serine protease, glycogen synthase, metalloproteinase, maturase, L-amino acid oxidase, plasminogen activator, adhesion, cysteine-rich secretory protein, disintegrin, fibronectin-binding protein, fibrinogen clotting inhibitor A chain, vascular apoptosis-inducing protein 1, pyranose 2-oxidase, carbamoyl-phosphate synthase, as well as the homology proteins of snake venom ablomin, ablomin, catrin, mucrofirase, pallabin, salmosin and triflin homologues were identified from the GSSV.

从GSSV中鉴定出超过25种蛋白组分，主要包括：酸性磷脂酶A1、碱性磷脂酶A2、神经生长因子、突触前神经毒素、出血因子、类凝血酶、丝氨酸蛋白酶、糖原合酶、金属蛋白酶、成熟酶、L-氨基酸氧化酶、纤溶酶源激活物、外源凝集素、富含半胱氨酸分泌酶、去整合素、纤连蛋白结合蛋白、纤维蛋白原凝固抑制因子A、血管凋亡诱导蛋白1、氨甲酰基磷酸合成酶、吡喃糖－2-氧化酶以及ablomin， catrin， mucrofirase， pallabin， salmosin和triflin的同源蛋白。

The paper to analyzes because experiments "factor contribution rate".to conduct the research;Discovered "the pure factor from difference square" for the negative value is the statistic stochastic value result;When the factor function is not extremely remarkable,the factor contribution rate also is a negative value;By now should merge not the remarkable factor square the random error square,recomputation ANOVA as well as factor technical progress factor.

论文对析因试验中用于分析因子作用的"因子贡献率"进行研究；发现"纯因子离差平方和"为负值其实是统计量随机取值的必然结果；尤其当因子作用极不显著时，计算的因子贡献率常常也是负值；这时应该将不显著的因子平方和并入随机误差平方和，重新进行ANOVA以及计算因子贡献率。

They experience feelings deeply and intensely, and their emotions are often mercurial.

他们的感情深刻而强烈，情绪善变。

Surrounded with or as if with a rampart.

用城墙围绕的用城墙围绕的或类似于为城墙围绕的