查询词典 pathological function

Objective To investigate the clinical and pathological significance of the lymphangiogenesis in squamous cell carcinoma of the esophagus.

目的探讨食管鳞状细胞癌组织中淋巴管形成的临床病理意义。

After one week, rats were treated with euonymus alatus as treatment group, and were treated with benazepril as western medicine control group at the same time in order to observe biochemical changes and pathological disorders.

目的：本研究通过建立大鼠 iga 肾病肾小球硬化模型，通过生化、病理切片观察中药鬼箭羽对iga 肾病肾小球硬化大鼠的治疗作用。

PART ONEInvestigation on Hp CagA+ strain infection condition and pathogenesis risk analyze in patients of carotid atherosclerosisObjective To observate pathological changes of carotid atherosclerosis as well as Hp infection situation, examinate blood fats, blood serum hs-CRP, blood plasma YKL-40, blood serum sCD14, analyze relations between Hp or Hp CagA+ strain and carotid atherosclerosis, and explore possible mechanism of carotid atherosclerosis caused by infection.

然后进行基础动物实验，应用Hp CagA+菌株干预高脂血症大兔，建立Hp CagA+菌株感染致兔颈动脉粥样硬化模型，进行血清Hp抗体、hs-CRP、血浆YKL-40水平检测、斑块内Hp DNA，进一步求证Hp CagA+菌株感染和颈动脉粥样硬化形成的相关性，Hp CagA+菌株感染是否可促进颈动脉粥样硬化的形成，深入探讨其可能机制，以期为颈动脉粥样硬化形成的病因学研究提供实验基础，为临床治疗颈动脉粥样硬化提供新的策略，从而完善其防治模式。

In vivo: to examine oncogenicity by heterotransplantation into nude mice in situ and pathological characteristics with HE and immunohistochemistry staining.

2体内实验研究：裸鼠原位接种检测该细胞株的致瘤性，组织化学染色观察其病理学特性。

Methods: Rat models of chronic renal failure were made by cut 5/6 kindney or fed with feedingstuff which contains adenine(0.75%) for 4 weeks. Experimental treatment was applied by giving Yi Shen Granule and the curative effect of Yi Shen Granule on ongoing pathological changes of CRF was studied. According to the data of CRF rats in weight, water wastage, hemanalysis(RBC、HGB、HCT、MCV、MCH), urinalysis(volume, specific gravity, pH, proteinuria), blood serum analysis(BUN、Cre、ALB、TP), kidney weight coefficient and kidney morphology ( the grade of expansile renal tubule and the diameter of glomerulus ),the pharmacological effect of Yi Shen Granule could be ascertained.

实验选用0.75%腺嘌呤饲喂法致大鼠慢性肾衰模型和5/6肾切除法致大鼠肾衰模型，考察益肾颗粒对慢性肾功能衰竭进行性病变的影响，以造模动物一般状况观察、血液学指标包括红细胞计数、血红蛋白、红细胞压积、平均红细胞体积、平均红细胞血红蛋白(RBC、HGB、HCT、MCV、MCH)，尿液指标(尿量、比重SG、pH值、尿蛋白)、血清生化学指标包括尿素氮、肌酐、白蛋白、总蛋白(BUN、Cre、ALB、TP)、脏器解剖和病理观察指标(肾小管扩张分级评分和肾小球径长)做为判定依据。

Objective: The purpose of our studies are gaining a better insight into the effect of genistein on mesangial cell"s phenotype change and ECM expression plus degradation under DN circumstances.We add genistein with different concentrations in high glucose cultured rat mesangial cells;feed DM rats with the single concentration genistein for different days;to explore the expression of SMemb,the mark of mesangial cell"s hypertrophy phenotype change;to examine the synthesis of Fn as well as the change of the balance between MMP-2 and TIMP-l;to comprehend its effect on renal pathological changes of DM rats and some related factors;trying toexplore the possible mechanisms.Through these studies,we will have some information about the experimental value of genistein in DN field.

目的：为了研究金雀异黄素对DN环境下大鼠MC肥大表型转换标志物SMemb和ECM分泌及降解的影响，我们拟在细胞水平以不同浓度的金雀异黄素作用于高糖培养下大鼠MC，在动物水平以同一浓度的金雀异黄素作用于DM大鼠不同时间，观察细胞表型转换标志物SMemb、ECM主要成分Fn、ECM降解酶系统基质金属蛋白酶—2(MMP-2)／基质金属蛋白酶抑制剂—1(TIMP-1)表达的变化，同时观察金雀异黄素对DM大鼠肾脏病理及影响肾脏病进展的糖脂代谢紊乱的影响，并进一步探讨金雀异黄素发挥作用的可能机制；为明确金雀异黄素在DN治疗中的地位及意义提供实验依据。

METHODS: Liver fibrosis models were established in 24 SD rats by intragastric administration (7 g/kg) of alcohol (56°, 560 mL/L) every morning, and 10 normal rats served as controls. The rats in model group were killed by exsanguination from femoral vein at 4, 12 and 24 wk. Pathological changes of liver tissues in rats were identified by Masson staining, and the expression of VEGF mRNA was detected by semiquantitative reverse transcription-polymerase chain reaction.

56度的白酒(560 mL/L)平均以7 g/kg的剂量每日早晨灌胃一次制备肝纤维化模型，灌胃4 wk、12 wk及24 wk采用股静脉放血法分别处死大鼠，观察肝脏病理变化并采用半定量逆转录聚合酶链反应检测VEGF mRNA的表达。

Primary atrial tumor has obvious characteristic on RT-3DE: All the atrial tumor display the same size of stereoimages as the tumor themselves. There is a clear boundary between the stereoimage of the myxoma and the atrial wall and there exists a short pedicle connecting the atrial myxoma to the atrial wall or the interatrial septum. The body of the atrial myxoma moves to and fro through the atrium and the atrioventricular valve with the contraction and relaxation of the heart with a fixative pedicle. Atrial myxoma leads to relative atrioventricular valve incompetence during systolic phase and relative atrioventricular valve stenosis during diastolic phase, but doesn't result in pathological changes of atrioventricular valve which restore to normal after exsection of the atrial myxoma. Malignant atrial tumor closely and extensively contact with atrial wall without obvious boundary, pedicle and movement with the contraction and relaxation of the heart.

所有心房肿瘤RT-3DE均实时显示与肿瘤大小相同的立体形态图像；心房黏液瘤立体形态图像与心房壁界限明显，都通过一短蒂与房间隔或心房壁相连，瘤体以蒂为固定点随心脏收缩、舒张在心房与房室瓣口之间往返运动；心房黏液瘤收缩期瘤体导致房室瓣相对关闭不全，舒张期瘤体导致房室瓣相对狭窄，但瘤体不引起房室瓣器质性病变，瘤体摘除后房室瓣功能即恢复正常；恶性心房肺瘤立体形态图像与心房壁关系密切，界限不明显，接触范围广泛，无蒂，瘤体不随心脏收缩、舒张运动。

Rapamycin may extenuate the pathological damage of IgAN rats by inhibiting JAK/STAT signaling pathway, activation of STAT3 and mesangial proliferation.

雷帕霉素可能通过抑制IgA肾病大鼠肾小球JAK/STAT信号途径、直接抑制STAT3的活化以及抑制系膜细胞的增殖而减轻病变程度。

He has developed a pathological fear for the exterior, to the point of limiting his contacts to only two people: the owner of the house, for whom he has a feeling of deep gratitude and respect that is translated into obedience; and Lupe, a friend, a confident and a lover.

他对外界抱有一种病态的恐惧，甚至只和两个人保持联络。一个是这座房子的主人，贝托对他又感激又尊重，因而对其唯命是从；另一个是他非常信任的朋友鲁贝。

My father is over 60 years old, and he lifts weights every day.

我爸爸六十多岁了，他每天都练习举重。

Then in a serious tone she declared:"It doesn't pay, dear boy, to look like a ninny with one's wife the first night."

两眼湿润了，她把身子蜷得很小，这样似乎可以更好地闻闻自己。