查询词典 maximum dose

After administration of Panax Tonifying Soup Mix with different doses, the number of neurons in brain cells was approximate normal value, and the anaplasia was also notably improved; hepatocyte proliferation, degeneration and necrosis were evidently suppressed; the effects in high dose group were most remarkable; and noticeable dose-effect relationship was observed.

给予不同剂量人参养荣汤干预治疗后，脑细胞神经元数目接近正常，退行性变化明显改善；肝细胞增生、变性及坏死显著被抑制；其中以高剂量作用显著，并且具有显著的量效关系。

Methods (1) Results were Compared between the measured dose in the anthropomorphic phantom and inverse planned dose.

（1）逆向调强计划的绝对剂量在仿真模型中进行测量比对。

The female salivary gland proteins were influenced by JH Ⅲ. Treatment on d2 after feeding, 10μg dose increased SG protein level and restrained 136kD protein gene expression. Treatment on d0 after engorgement, 10μg, 50μg and 100μg doses significantly increased the d2 SG protein and 100μg dose made 35kD protein gene expression, 200μg treatment made the 136kD and 192kD proteins absent. This is the first found that JHs regulate arthropoda SG activity.

保幼激素对雌蜱唾液腺蛋白及成分有影响，吸血后2天处理，10 μg剂量使唾液腺蛋白含量明显增加，抑制136kD蛋白的基因表达；饱血当天处理，10μg、50μg和100μg显著提高饱血后2天唾液腺蛋白含量，100μg使35kD蛋白表达，200μg使136kD和192kD的蛋白缺矢；饱血当天处理，1μg和10μg剂量均能显著提高饱血后4天雌蜱唾液腺蛋白含量，高剂量（100μg）抑制136kD蛋白的表达，该结果首次报道了保幼激素对节肢动物唾液腺的调控作用。

OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

目的为利用临床常规监测的血药浓度数据估算病人的个体药动学参数，优化给药方案，设计、研制了临床药动学给药个体化系统CPKDP程序方法依据群体药动学原理及Bayes公式，CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发，在希望汉字系统UCDOS 5.0平台上运行结果CPKDP程序适用于具有不同药动学特征的多种药物，适用于不同给药途径的单剂量或多剂量给药在群体药动学参数的基础上，结合病人个体特征，以1，2个血药浓度作为反馈，即可拟合估算个体药动学参数，优化给药方案结论经初步应用，CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具

The simultaneity use of Xiao Er Chuan Ke Ye and Cang Er Zi San intervening asthma and allergic rhinitis,comparing simply use Xiao Er Chuan Ke Ye,has the predominance in prolonging time of introducing asthma and reducing the frequency of nodding breathe,which indicated that the treatment of allergic rhinitis has great importance in asthma control and lessen the degree of asthma(frequency of rat nodding breath).3,The combination high-dose group has better therapeutic effect than dexamethasone group,all Chuan Ke Ye groups and combination low,medium group in the prevention and control of allergic rhinitis symptoms,reduced airway hyper responsiveness,while in improving breath difficulties combination high-dose group has similar effect with western medicine group,and better effect than all Chuan Ke Ye groups and combination low,medium group.Its efficacy increased with the prolonging of treatment time,but fewer side effects,which makes the application safer and more reliable.4,Xiao Er Chuan Ke Ye combining with Cang Er Zi San can obviously improve the pathological changes in rats with bronchial airway remodeling,reducing the serum TGF-β1,IL-4,ECP levels,increasing the level of serum IFN-γand the imbalance IFN-γ/ IL-4 ratio.

而运用小儿喘咳液合苍耳子散同时干预哮喘与过敏性鼻炎，较之单纯使用小儿喘咳液治疗哮喘，其在延长引喘时间、减少点头呼吸频度等方面有明显的优势，说明过敏性鼻炎的治疗，对于控制哮喘发生，减轻哮喘发作的程度，有着重要的意义。3、大剂量的合方在预防和控制过敏性鼻炎症状、降低哮喘气道高反应性方面疗效较地塞米松对照组、喘咳液各剂量组及合方小、中剂量组更优，而改善呼吸困难方面则与西药组相当，优于喘咳液各剂量组及合方小、中剂量组，且其疗效随着治疗时间的延长而增加，但副作用更少，使用更加安全可靠。4、小儿喘咳液合苍耳子散能明显改善气道重塑大鼠支气管的病理改变，同时降低血清TGF-β1、IL-4、ECP水平，提高血清IFN-γ水平及失衡的IFN-γ/IL-4比值。

In a 2-week, double-blind, placebo-controlled study of 186 people with intermittent allergic rhinitis, use of butterbur at a dose of three standardized tablets daily, or one tablet daily, reduced allergy symptoms as compared to placebo.34 Significantly greater benefits were seen in the higher dose group.

在为期2周的，对186名患有间歇性过敏性鼻炎患者进行安慰剂控制的双盲研究中，分别给患者服用每天3片和每天1片的剂量，将结果与安慰剂试验进行比较，高剂量能明显减轻过敏症状，2个剂量的不同肯定了这种治疗是有效的。

The resultsshowed that CAs and CaMAs could both enhance the intracellularDoxorubcine level and decrease the membrane P-Gp expression of K562/VCRcells,indicating there existed significant difference with the control group(P＜0.01).And the changes of the intracellular Doxorubcine concentrationinduced with CAs and CaMAs had positive dose-responses relationship withCAs and CaMAs concentration in K562/VCR cells(P＜0.01),while thechanges of membrane P-Gp expression had no dose-responses relationshipwith CAs and CaMAs concentration in K562/VCR cells.

结果表明：CAs或CaMAs既能提高K562/VCR细胞内Dox的浓度，又能降低K562/VCR细胞膜P-Gp的表达，与对照组相比，存在着明显差异（P＜0.01）；CAs和CaMAs各浓度间引起的K562/VCR细胞内Dox浓度的变化也存在着明显的差异（P＜0.01），呈正的量效关系；但CAs和CaMAs各浓度间引起的P-Gp表达的变化无明显差异。

Except for 2μmol/L Verapamil,other concentrations ofCAs and CaMAs could decrease mdr1 mRNA expression level of K562/VCRcells,indicating significant difference from those of control group(CAs:P＜0.05;CaMAs:P＜0.01),but the changes of mdr1 mRNA expression levelcaused by CaMAs had negative dose-responses relationship with CaMAsconcentration(P＜0.05),while the changes of mdr1 mRNA expression levelinduced with CAs had no dose-responses relationship with the CAsconcentration.

除〓的Ver外，其它浓度的CAs和CaMAs均可降低K562/VCR细胞mdr1 mRNA表达水平，与对照组相比，存在着明显差异（CAs：P＜0.05；CaMAs：P＜0.01）；并且CaMAs各浓度间引起的mdr1 mRNA表达水平的变化也存在着差异（P＜0.05），呈负的量效关系，而CAs各浓度间引起的mdr1 mRNA表达水平的变化无明显差异。

Methods :Sixty patients with CHF were randomly divided into routine therapy group(control group,n=18),which were administered cardiotonic,diuretic and vascellum expander;low dose atorvastatin group (n=20)and high dose atorvastatin group (n=22),which were supplemented by atorvastatin 10mg/day and 40mg/day separately, besides the routine therapy for 8 weeks.

60例CHF患者分为3组，对照组(n=18)常规予强心、利尿和血管扩张剂治疗，小剂量阿托伐他汀组(n=20)在前者基础上加用阿托伐他汀片(10mg/d)，大剂量阿托伐他汀组(n=22)则在基础治疗上加用阿托伐他汀片(40mg/d)，各治疗8周。

Pae (25-100mg/kg, ip) not only inhibited the swelling of mouse pinnea induced by xylene in a dose-dependant manner, but also suppressed the edema of rat hind paw induced by injection of 1% carrageenin at a higher dose (100 mg/kg, ip).

Pae(25-100mg/kg，ip)可剂量依赖性地抑制二甲苯所致的小鼠耳肿胀，高剂量(100mg/kg，ip)时可抑制角叉菜胶所致的大鼠足跖肿胀。

It inculcates justification before God on the ground of human merits.

它说明在上帝灌输在地上人类优点。

TH Leaguer has excellent Quality Control and Management System.

本公司具有完善的品管部门。