查询词典 maximum dose

A new study just published in the International Journal of Cancer examined the activity of chlorophyllin and found that, on a dose-by-dose basis , it was 10 times more potent at causing death of colon cancer cells than hydroxyurea, a chemotherapeutic drug commonly used in cancer treatment.

根据国际癌症杂志的一项对叶绿酸的活性研究，发现同等剂量下，它比常用的化疗药物羟基脲在杀死结肠癌细胞的作用要强10倍。

Results The cytotoxicity of chrysotile asbestos was in a dose and incubation time dependent manner. After 18 h incubation and at the dose of 250 μg/ml, the cell death rate and LDH content were increased significantly.

结果 纤状蛇纹石石棉对肺泡巨噬细胞的毒性存在着剂量-效应关系、时间-效应关系；125 μg/ml培养18 h后，细胞死亡率及LDH增加，500 μg/ml培养5 h后，细胞死亡率、LDH、MDA均明显增加，而SOD活力明显降低。

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

Days after a convulsant dose of KA, the seizure susceptibility were found in KA+NS group and enhanced in KA+PL017 group, whereas significantly decreased in KA+β-FNA group (p.01).β-FNA prolonged the latency and reduced the stage of seizures in dose-dependent manner.

结果显示，一次给予惊厥剂量KA后7天，KA+NS组的癫癎发作敏感性形成；MORs激动剂组（KA+PL017）动物出现癫癎发作敏感性增强；与上述两组比较，MORs拮抗剂组动物癫癎发作敏感性明显降低（p.01），β-FNA以剂量依赖方式延长癫癎发作的潜伏期、降低发作级别。

The seizure sensitive rats were made by subcutaneous injection of a convulsant dose (10mg/kg) of KA. Normal saline , PL017 or β-FNA were infused constantly into ventral hippocampus of awakened and freely moving animals for 7 days by mini-osmotic pumps. 7 days later, all rats were given subcutaneously with subconvulsant dose of KA.

皮下注射惊厥剂量（10mg/kg）的KA制备颞叶癫癎模型的癫癎发作敏感大鼠，采用微渗透泵技术分别将生理盐水、PL017和β-FNA连续7天恒速注入清醒自由活动的上述动物的腹侧海马内。7天后皮下注射阈下剂量（5mg/kg）KA检测癫癎发作敏感性形成情况。

In this study, for the complicated distribution of dose rate in time and space, considering the repair of the sub-death cells, the radionuclide decay law and exponential proliferation of clonogenic cells, the dose-response relationship is built based on the known linear-quadratic model, and the concept of tumor control probability is introduced into the therapy method. Furthermore, the concepts about "curable stage" and "critical time point" and the methods calculating the amount of radionuclide injected into tumor in clinical are proposed.

本课题针对这一方法中靶区复杂的剂量率时-空分布特点，以公认的"线性-二次模型"理论为基础，同时考虑亚致死性细胞修复、核素衰变规律和克隆原性细胞指数增殖，建立了适合这一治疗方法的具有时-空分布特点的剂量效应关系，并进一步将肿瘤控制概率的概念引入这一方法中，提出了"治愈期"及"临界时间点"的概念以及由此指导临床确定药物注射剂量的方法。

Among the 6 recurrent cases, one had new coronary artery lesions; three had expanding coronary artery lesions. Among the 3 cases that recurred within 2 months, IVGG and ASA had not been used in one case, and ASA was reduced to low dose just 3 days after defervescence in 2 cases. The cases that recurred within 2 months were more likely to occur in which ASA was reduced to low dose just 3 days after defervescence than those in which gradually.

再发病例6例，其中1例有新的冠状动脉损害形成，3例原有冠状动脉损害加重。3例在初发病2月内再发者，其中1例未用IVGG及ASA治疗，2例热退后ASA快速减量。

Our Demerol dose is felt 10-15 minutes after the dose begins and lasts anywhere from 2 to 4 hours.

我们认为Demerol剂量10-15分钟后，剂量开始，持续时间从2至4小时。

The required dose of local anesthetics to get analgesia per dermatome was calculated according to the anesthetics dose and the number of dermatomes blockade.

为此对近十年2050例硬膜外阻滞麻醉资料进行了回顾性分析，进一步探讨在临床中硬膜外穿刺部位对药物扩散的影响。

Illustrative results are presented for the radiation dose and dose profile with activity distributions: uniform, determined by steady-state diffusion into the target volume, or determined by steady-state diffusion with a constant rate of loss of activity from the target.

计算程序用Visual Basic V6.0编写，在微机上运行。为了验证计算结果，将均匀分布条件下的计算结果分别与文献报导的结果比较，发现它们是一致的。

He tendered his resignation to the Prime Minister.

他向首相递了辞呈。不适合

International economy and trade,Nanking 210044

国际经济与贸易，南京 210044