查询词典 drug

OBJECTIVE To design and develop a clinical pharmacokinetics and individual drug dosage regimens system CPKDP program for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS According to the principle of population pharmacokinetics and Bayes" formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient"s pharmacokinetic parameters were estimated based on population-average pharm-acokinetic parameters. CONCLUSION CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

目的为利用临床常规监测的血药浓度数据估算病人的个体药动学参数，优化给药方案，设计、研制了临床药动学给药个体化系统CPKDP程序方法依据群体药动学原理及Bayes公式，CPKDP程序用FOXPRO 2.6和BORLAND C++ 3.1开发，在希望汉字系统UCDOS 5.0平台上运行结果CPKDP程序适用于具有不同药动学特征的多种药物，适用于不同给药途径的单剂量或多剂量给药在群体药动学参数的基础上，结合病人个体特征，以1，2个血药浓度作为反馈，即可拟合估算个体药动学参数，优化给药方案结论经初步应用，CPKDP程序是应用Bayes反馈法开展临床个体化给药工作非常实用的工具

The teaching of this course aims to combine with the pharmaceutical practice on the basis of understanding the fundamental pharmaceutical preparation technology, to enable the students to be familiar with the properties of the commonly used drug adjuvant preparation. they are to learn to grasp the adoption principle of pharmaceutical adjuvant preparation, apply drug adjuvant accurately, and facilitate the function of drug, so as to be at more ease with pharmaceutical research and study in the future.

本课程结合药剂学理论和药品生产的实际，阐述药用辅料在药剂剂型结构中的作用，重点讨论各类制剂中常用辅料的品种、作用、特点、性质及选择应用的原则和方法，使学生在了解基本制药技术的基础上，能更多地结合制药生产实际，熟悉常用药用辅料的性质，掌握制剂制备时药用辅料的选用原则，准确地应用药用辅料。

For matrix tablets, the results indicate that drug release rates can be decreased by increasing amount of carnauba wax and lubricant, or by reducing particle size of drug. Manufacturing process/methods also affect drug release rate.

对疏水性间质锭剂而言，增加巴西棕榈蜡和润滑剂的使用量，或是降低柠檬酸钾的颗粒大小，皆会降低药物溶离的速率，而制备锭剂方法及制程的改变也会影响药物的溶离速率。

It is learnt that the community in our province of drug treatment from June 2004 has been officially launched so far, there have been 54 community drug methadone maintenance therapy clinic Kaizhen According to statistics, from four years of out-patient situation, there are Nearly 10,000 "drug addicts" access to methadone maintenance therapy.

据悉，我省社区药物维持治疗工作从2004年6月正式启动以来，到目前为止，已相继有54个美沙酮社区药物维持治疗门诊开诊，据统计，从四年的门诊情况看，目前已有近10000名"瘾君子"获得美沙酮维持治疗。

Tablet machinery,injection machinery,machinery for medicine powder and liquid antibiotic vial,infusion machinery,machinery for hard capsule,machinery for soft gelatin capsule,pill machinery,unguent drug machinery,suppository drug machinery,oral liquid drug machinery,eyedrops machinery, electuary.

片剂机械、水针剂机械、粉针剂机械、输液剂机械、硬胶囊剂机械、软胶囊剂机械、丸剂机械、软膏剂机械、栓剂机械、口服液剂机械、滴眼剂机械、冲剂。

Hypoxanthine and a uricase inhibitor were combined into the model drug to work out the rat＇s animal model for hyperuricemia. A comparison was made between the effect of hypoxanthine and that of the model drug on the subject＇s serum uric acid levels. Also, such factors as the dose effect and time effect of the model-building drug were investigated.

采取合用次黄嘌呤和尿酸酶抑制剂为模型药物，制备一种尿酸生成增多型大鼠高尿酸血症动物模型，比较了单用次黄嘌呤及合用尿酸酶抑制剂对受试动物血清尿酸水平的影响，并对造模药物的量效、时效关系等因素进行了考察。

Its basic and applied clinical research is directed to drug metabolism and drug action, its aim is to understand endogenous and exogenous factors underlying the large interindividual variability in drug response.

该研究所的基础与应用临床研究方向是药物代谢和药效，其目标是理解潜在于巨大的个体间差异下，引起药物反应的各种内源和外源因素。

The fact that China legislatively punishes drug-connected crimes with severity is required by the reality of the anti-drug struggle, and shows China's stand for strict drug control.

中国在立法上对毒品犯罪从严惩处，是现实禁毒斗争的需要，表明了中国严厉禁毒的立常

METHODS: Both diastolic and systolic blood pressures repeated measures data, collected from 120 drug abusers after taking two kinds of medicine (Drug A: Xiaoyinfuzheng, Drug B: Kelening), were analyzed by multivariate random coefficients model. The fixed effect parameters matrix x of model coefficients were estimated by using least squares estimation method, the effects between treatment groups were compared and the variancecovariance matrices of random effect were also estimated.

对两种药物（A药：消瘾扶正胶囊，B药：可乐宁）治疗120例患者后的舒张压和收缩压重复观测数据进行多变量随机系数模型分析，对模型系数的固定效应参数矩阵ξ作最小二乘估计并进行组间比较，同时估计随机效应的方差协方差矩阵，分析方法用SAS/IML软件编程得以实现。

METHODS: Both diastolic and systolic blood pressures repeated measures data, collected from 120 drug abusers after taking two kinds of medicine (Drug A: Xiaoyinfuzheng, Drug B: Kelening), were analyzed by multivariate random coefficients model. The fixed effect parameters matrix x of model coefficients were estimated by using least squares estimation method, thelunwen114 effects between treatment groups were compared and the variancecovariance matrices of random effect were also estimated. Related analysis methods were programmed with SAS/IML code.

对两种药物（A药：消瘾扶正胶囊，B药：可乐宁）治疗120例患者后的舒张压和收缩压重复观测数据进行多变量随机系数模型分析，对模型系数的固定效应参数矩阵ξ作最小二乘估计并进行组间比较，同时估计随机效应的方差协方差矩阵，分析方法用SAS/IML软件编程得以实现。

Objective: To study the effect of polycythemia on blood oxygen saturation.

裴蕾目的：观察RBC剧增而引起的高粘血症对血氧饱和度的影响。

Based on SIMPLER algorithm in the curvilinear body-fitted coordinates, the calculations were performed for Pr=0.7, Re=10~1000 on non-orthogonal non-staggered grids which are generated by elliptic equation systems.

采用曲线坐标系下压力与速度耦合的SIMPLER算法，数值研究了周期性渐扩渐缩波纹通道内脉动流动与换热情况，流动Re数的范围为10~1000，Pr数为0.7。