查询词典 deletions

Oncogenic transformation of c-abl to v-abl occurs by insertional activation that results in deletions of specific N-terminal amino acids.

由abl癌基因编码的转化蛋白。c-abl到v-abl的致癌性转化由于插入激活而发生并引起特异性氨基末端氨基酸删除。

Reverse transcription polymerase chain reaction was used to examine the deletions at P16 and FHIT in 52 patients with lung cancer and 9 patients with nonmalignant disease.

采用逆转录——聚合酶链反应方法，对52例肺癌患者和9例肺良性疾病患者的纤支镜活检标本中P16和FHIT基因缺失情况进行检测。

Curran and a team of American and Canadian researchers, in conjunction with the Philadelphia-based Radiation Therapy Oncology Group, a federally-supported clinical trials organization, found that among 289 patients with either anaplastic oligodendroglioma or anaplastic oligoastrocytoma receiving either a combination of three chemotherapy drugs with radiation or radiation alone, those whose tumors had deletions in chromosome locations 1p and 19q tended to live nearly two and a half times longer than those patients without the missing chromosome portions.

临床癌症杂志》上周报道，卡仑博士和由美国、加拿大研究人员组成的科研小组，联合了总部设在费城的由联邦政府支持的临床实验组织－美国放射肿瘤学协作组，进行了研究。289名病人患有退行性少树突神经胶质瘤或退行性少星细胞瘤，研究发现，这些病人在接受三种化疗药物结合放疗或者只接受放疗后，其中染色体缺乏1p 和19q 的病人比那些不缺乏的病人多存活了2倍半的时间。

Comparative analyses show a fascinating picture of conservation and divergence, revealing large blocks of gene orthology with rodents, scattered regions with more recent gene family expansions and deletions, and segments of coding and non-coding conservation with the distant fish species Takifugu.

比较分析表现出一副保守和分化的有意思的图片，一方面染色体中展示了一大组与啮齿类动物同源的基因，还有更多新近基因家族扩张和缺失的散步区域以及和进化上遥远的鱼类东方鲀具有的编码和非编码的保守片断。

The results are: 1 the stricture of the capillaries of stria vascularis was observed in most cochleae of rickety rats and, segmental deletions of the outer hair cells on the first turn of cochlea were found in a small number of rickety rats; 2 the perilymphatic ionized calcium concentration significantly re- duced and the threshold of CAP (Compound Action Poten- tials of the eighth nerve) significantly rose in rickety rats in comparison with those of normal control; 3 gentamicin results in an increase of the perilymphatic ionized calcium concentra- tion in rickety rats; 4 the cochleae of the rickety rats appeared to be less vulnerable to the ototoxicity of gentamicin than the normal one.

研究包括两个方面，其一是&佝偻病的感觉神经性耳聋及其对庆大霉素耳毒性作用的耐受性&，系用大白鼠建立维生素D缺乏性佝偻病动物模型，发现：（1）佝偻病大白鼠耳蜗血管纹毛细血管狭窄，少数动物耳蜗底回外毛细胞有节段性缺失；（2）佝偻病大白鼠的耳蜗鼓阶外淋巴钙离子浓度降低，CAP（听神经复合动作电位，以下简称CAP）听阈提高；（3）庆大霉素可使佝偻病大白鼠耳蜗外淋巴钙离子浓度上升；（4）佝偻病大白鼠耳蜗在功能和形态上都比正常者更能耐受庆大霉素的耳毒性损害。

Pombe which is not responsible for pseudouridylation of rRNA or snRNA. At last, genetic analyses of the functions of one pseudouridylation guide and two orphan guide snoRNAs were carried out by gene deletions.

最后，本文还利用同源重组方法对1个指导假尿嘧啶化修饰的功能snoRNA分子SP20和两个orphan-guide snoRNA分子SP12和SP16进行了基因缺失的遗传学分析。

Objective To determine whether or not the mtDNA4977 deletions contribute to human aging and involve in the development of presbycusis.

目的 探讨mtDNA4977缺失与老年聋的关系。

However, the incidence of carrying mtDNA4977 deletions in heart and liver were no significant difference between presbycusis patients and the control group.

老年聋患者颞骨切片和蜗核组织中mtDNA4977缺失的发生率明显高于老年听力正常组，其差异具有显著性意义（χ2检验，P＜0.05）；而与听觉无关的心肌和肝脏组织中mtDNA4977缺失发生率在两组之间差异无显著性。

All the LOH on 〓 and 〓 was observed in invasive ductal carcino- ma, carcinoma simplex, medulary carcinoma and scirrhous carcino- ma, no deletions at these sites were observed in any invasive lobular carcinoma and others. These results imply an etiological difference.P53 gene is a hot point gene in the occurrence and development of breast, cancer. PCR-SSCP analysis was performed to detect P53 gene point mutation in the region between exon 5 and 8, 5 of 12 (41. 6%) stage I breast cancer patients contain mutation of P53, 3 of 5 patients were accompanied by 〓 deletion. These results suggested that point mutation and allelic loss of P53 gene are two vi- tal genetic events in earlier stage of breast tumorigenesis.

我们还发现，〓和〓位点LOH均分布在乳腺浸润性导管癌、单纯癌、髓样癌及硬癌中，在浸润性小叶癌和某些特殊类型乳腺癌中全部为LOH阴性，上述位点LOH可能与某些组织学类型乳腺癌的发生有关。P53基因是乳腺癌形成过程中的一个热点基因，本研究对12例Ⅰ期乳腺癌组织标本中P53基因热点区域第5、6、7、8外显子点突变进行了测定，发现41.6％（5／12）的病人有P53基因一个或多个点突变，其中3例同时伴有〓位点LOH，表明P53基因点突变和等位基因缺失是发生在乳腺癌形成早期的一个重要遗传学事件。

The shredder intercepts these unsecure deletions and replaces them with secure procedures.

该碎纸机截取这些不安全的缺失，并取代他们的安全程序。

He and Nina moved to California and lived at 2005 Ivar Street, Apt.

他和Nina搬到加州，并在2005年伊瓦尔街，公寓生活。

Droperidol （ potently inhibits transfected HERGchannels and this is the probable mechanism for QT prolongation.

氟哌利多有效地抑制了转染的 HERG 钾通道，可能是 QT 间期延长的机制。