查询词典 clonal

Based on the clonal selection principle and idiotypic immune network theory exhibited in biological immune system, a new immune algorithm-the clonal selection adjustment algorithm is proposed.

基于生物免疫系统克隆选择机理和独特型免疫网络理论，提出了一种新的免疫算法―克隆选择调节算法。

Based on the clonal selection algorithm, with the combination of the dynamic adjustment idea between antibodies of the idiotypic immune network theory, a new immune algorithm, the clonal selection adjustment algorithm, is proposed and applied to the design of IIR digital filter.

在克隆选择算法的基础上，结合独特型免疫网络理论中抗体间的自适应动态调节思想，提出一种新的免疫算法―克隆选择调节算法，并用于IIR数字滤波器的设计。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Based on this mechanism, a clonal selection algorithm for multi-modal function optimization has been proposed by formulating suitable clonal selection operators and introducing a new niching technology in this paper.

多目标优化问题的解不是唯一的，而是一个最优解集合。这类问题大多有较高维的搜索空间，传统的优化方法会导致很高的时间复杂性。

This study was purposed to investigate the dynamic change of clonal proliferation of T cell receptor V subfamilies in peripheral blood of patients received allo-hematopoietic stem cell transplantation and to analyze the relationship between T cell clonal proliferative changes and GVHD.

本研究观察异基因造血干细施移植患者外周血T细胞受体Vβ亚家族克隆性增殖的动态变化，分析T细胞的克隆性演变与GVHD的关系。

This study was purposed to investigate the dynamic change of clonal proliferation of T cell receptor V subfamilies in peripheral blood of patients received allohematopoietic stem cell transplantation and to analyze the relationship between T cell clonal proliferative changes and GVHD.

本研究观察异基因造血干细胞移植患者外周血T 细胞受体 Vβ亚家族克隆性增殖的动态变化，分析T细胞的克隆性演变与GVHD的关系。

Aims Polygonum viviparum, which is widely distributed in eastern Qinghai-Tibet Plateau in China, is a clonal plant species with two modes of reproduction, clonal propagation by below-ground rhizomes and bulbils and sexual by seeds.

珠芽蓼是青藏高原东缘广泛分布的克隆植物，具有有性和无性两种生殖方式。

In ordet to verify whether it is clonal aberration or not, more cells are needed to be analyzed.

为了确定这样的异常是否为克隆性，有必要分析更多的细胞。

Alstroemeria aurea is a perennial herb with clonal rhizomatous growth, insect pollination, and ballistic seed dispersal that inhabits a range of different environments in the southern Andes.

Alstroemeria aurea是一种多年生草本植物有著以地下茎的生长，昆虫授粉和弹出的种子散布进行舞殖，在南安地斯山脉中可以栖息在不同环境之下。

Clonal anergy and suppressor cells are main mechanisms of the tolerance.

克隆不应答和抑制细胞是耐受的主要机制。

It has to be computed by the host for the actual clock rate.

主控制器可以用来计算实际的时钟速率。

Let's see what you got.

让我看看你的东西