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The regulation of gene expression is to have relations to the assembly of the DNA binding proteins which bind to DNA to initiate the transcription. Some of these proteins have the ability to promote bending or looping of DNA. The FIS protein regulates gene expression in Escherichia coli by this property of bending DNA. There are many researches to discover the mechanism of FIS protein binds to DNA. However the experiment data only show the supposititious results and figure out the model of FIS-DNA complex structure. This research uses molecular dynamics simulation to compute the detail of the interaction between FIS and DNA. We observed FIS prominently affects the DNA bending by the type of local bending. Analyzing the DNA structure properties, roll and slide, also demonstrates the local bending type and region. The hydrogen bonds between FIS and DNA are analyzed to compare with the experiment data. Finally we compute the binding free energy between FIS and DNA to estimate the result of simulation and compare with the value of λ-repressor-DNA complex.

基因的表现与结合於DNA促使DNA转录作用起始的DNA结合蛋白组装有关,一些这类的蛋白质具有促使DNA扭曲或将DNA形成环状的能力,FIS蛋白质即是藉由扭曲DNA的特性调控大肠杆菌基因的表现,目前已有很多的研究发现FIS与DNA结合的机转,然而这些实验的数据仅能显示推测性的结果,进而利用这些结果推论出FIS与DNA聚合体结构的模型,本研究利用分子动态模拟的方式计算FIS与DNA交互作用的细节,我们观察到FIS主要影响DNA的扭曲方式为DNA区域扭曲的类型,并且分析DNA结构特性roll与slide也指出扭曲方式为区域扭曲与其扭曲的区域,我们也分析FIS与DNA之间的氢键,并且与实验的资料作比较,最后我们计算FIS与DNA之间的结合自由能评估模拟的结果,并且计算出的值和λ-repressor与DNA聚合体结构的实验值作比较。

All movies received by the Lender from the Chargor or am other person may be applied by the Lender to such account or liability hereby undertaken to be paid or otherwise hereby secured as the Lender in its absolute discretion may from time to time conclusively determine whether or not the same shall have become due and whether or not the security created by this Deed shall have become enforceable and any surplus for the time being may be retained by the Lender and held in a suspense account pending application as aforesaid.

被来自 Chargor 的出借人收到的所有电影或是其他的人特此可能被应用被出借人到如此的帐户或责任接手到被支付或者其它的特此保护如它的 absolute 的出借人慎重可能偶尔决定性地决定是否一样的将已经变得适当而且是否被这一种行为产生的安全将暂时已经变得可运行的和任何的剩余可能被保有被那出借人而且在一个悬疑帐户中捉住当申请的时候如上述的。

Because I thought that the French were simply megalomaniacs and this whole project would probably never happen, and because I was surrounded by this rope of expectant experts, I decided to bluff and said, we know exactly how to resolve this problem: where the two lane TGV railway widens to six, we will run the highway parallel to the station. We will also run it underground, and in between, we will create the largest parking lot in the history of Christendom--8, 000 places, and in this way, an unbelievable metropolitan concentrate of infrastructure. We used this underground literally as the basis for our project.

因为我以为法国人仅仅是夸夸其谈,整个项目根本不可能实现,也因为我背负着一桌子专家的殷切期待,我决定直率地陈述我们的观点,我们确实知道如何解决这个问题:在两条TGV轨道扩大到6条的地方,高速公路会平行于火车站,并被埋入地下,然后修建一个8000位的停车场,这将是基督教世界历史上最大的停车场,通过这种方法我们能够创造一个集中了巨大地下基础结构的大都会。

This improvement in accuracy is made possible by a unique, patented multipoint laser compensation technique developed by Thaler Corporation.

This在准确度的改善是由一个独特的,专利的多点激光补偿泰勒公司开发的技术可能系数V输出。

In this dissertation, the scale-up experiments of the decomposition of toluene by pulse corona discharge in wire-plate reactor were investigated systematically, at the same time, The experiments of the decomposition of refinery odors by this technology were also studied. A pulse power based on thyratron switch, Blumlein pulse forming network and pulsed transformer was adopted.

基于上述小试成果,本文主要对有机废气中的代表性污染物模拟甲苯废气,在线板式反应器内进行了系统的放大试验研究,同时将该技术应用于实用目标炼油厂模拟恶臭废气(工业上排放的恶臭废气主要是含硫含氮的挥发性有机废气)的治理。

In this paper a decision method of uniform convergence for function sequence is given, and a few of properties for the uniformly convergent function-sequence are obtained by this method, which is used in the construction of a new uniformly convergent function-sequence by others known.

给出了一个定理用于判定函数列的一致收敛,通过此判定定理,又得出了由一致收敛函数列构造新的一致收敛函数列的几个性质。

The viva voce agreement upon some person, made according to human custom by the electors or by the greater part of them, does not mean by itself that the person has been legitimately elected or that by this very fact he is the true and manifest successor or vicar of the apostle Peter or of another apostle in an ecclesiastical office.

该借助协议后,一些人,按人的习俗,由选民或者更大的其中一部分,这并不意味着自己该人已被合法选举产生,或由这一事实,他是真正体现了继承人或副主教的使徒彼得或另一种使徒在教会办公室。

By this, the long wished-for opportunity was offered to "True" Socialism of confronting the political movement with the Socialist demands, of hurling the traditional anathemas against liberalism, against representative government, against bourgeois competition, bourgeois freedom of the press, bourgeois legislation, bourgeois liberty and equality, and of preaching to the masses that they had nothing to gain, and everything to lose, by this bourgeois movement.

于是,"真正的"社会主义就得到了一个好机会,把社会主义的要求同政治运动对立起来,用诅咒异端邪说的传统办法诅咒自由主义,诅咒代议制国家,诅咒资产阶级的竞争、资产阶级的新闻出版自由、资产阶级的法、资产阶级的自由和平等,并且向人民群众大肆宣扬,说什么在这个资产阶级运动中,人民群众非但一无所得,反而会失去一切。

She was stirred by this thought, angered by that -- her own injustice, Hurstwoods, Drouets, their respective qualities of kindness and favour, the threat of the world outside, in which she had failed once before, the impossibility of this state inside, where the chambers were no longer justly hers, the effect of the argument upon her nerves, all combined to make her a mass of jangling fibres -- an anchorless, storm-beaten little craft which could do absolutely nothing but drift.

她想到自己的不是,赫斯渥的不是,杜洛埃的不是,又想到他们各自对自己的情意和帮助。她想到出外谋生的艰难--她已经失败过一次了。她又想到不可能再留在这里了,她已经没有资格住在这些房间里了。这些思绪再加上吵架给神经带来的压力,使她的思想就像一团乱麻,理不出个头绪来--一条没有锚的小船受风雨的摆布,除了随波逐流,无能为力。

The NO content and the NOS activity were down in the PIH pregnant women placenta.This showed that the ghrelin regulated the VEGF and influenced the the NO down.And the placenta angiospasm,blood pressure highten, and the PIH were caused also by this. The ghrelin,VEGF,Flt-1,NO and NOS were detected by the SP-immunochemistry, RQ-PCR,cell culture in vitro,ASODN and nitrate reductase in the normal pregnancy,PIH placenta and the cultured HUVEC antisense blocking ghrelin in vitro.

结果证实:PIH孕妇胎盘组织中Ghrelin,VEGF、Flt-1蛋白和mRNA水平下降与正常孕妇比较有显著性差异p<0.05提示在PIH发病过程中Ghrelin可能对VEGF,Flt-1蛋白和mRNA的表达具有下调作用,进而影响胎盘血管网的形成和发育;NO含量与NOS活力水平在PIH孕妇胎盘组织中下降,提示Ghrelin可能通过下调VEGF的表达进一步影响血管舒张因子NO水平下降,进而引起胎盘血管痉挛,血压升高,最终导致PIH的发生。

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推荐网络例句

Chrysanthemum of 10 thousand birthday is lax to edaphic requirement, with the arenaceous qualitative loam with fecund, good drainage had better.

万寿菊对土壤要求不严,以肥沃。排水良好的砂质壤土为好。

He unstepped the mast and furled the sail and tied it.

他拔下桅杆,把帆卷起,系住。

Therefore, positively advances the interest rate marketability reform is one of current our country finance reform important tasks.

因此,积极推进利率市场化改革是当前我国金融改革的重要任务之一。