查询词典 activation process

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

The thesis studies the difference between GWSs composition and traditional workflow applications, proposes the implement mechanism and technical architecture of GWSs composition and defines the reference model of GWSs composition platform, which provide holistic framework and top-level guidance for studying dynamic GWSs composition technology, designing GWSs composition platform, and implementing representative composite service applications.2、Theories and methods of composite process modeling and process analysis. This thesis proposes a meta-model of Geo-spatial Web services composition process defining from two aspects, i.e. process and resource. According to the process definition meta-model, we propose a new Geo-spatial Web services composition Process/Resource model based on extended WF-net, which effectively resolves the problems on uncertain activity option and dynamic variation of service in composite process model. A notion with regard to soundness of process model is proposed from three aspects, i.e. the structural correctness of process model, validity of data link and validity of resource. The notion of soundness definitely gives a dividing line on correctness of composite GWS process. This thesis analyzes sufficient and essential terms of soundness, and studies compositional property of WSCP/R-net models which provides an effective method to construct a soundness WSCP/R-net model. According to WSCP/R-net, the thesis proposes composition algebra and studies the properties of it. Based on the composition algebra, 6 kinds of composite process reduction rules are induced to optimize the process.3、Geo-spatial Web service QoS model and its application architecture. This thesis proposes an extendable GWS QoS model from three aspects, i.e. Geo-spatial Web Service itself, networking conditions and service consumer which can be used to distinguish GWSs with overlapping or identical functionality. We work over the QoS evaluation methods of composite GWS process which can be used to guide the execution, monitor and service selection of composition process. Aming at some disadvantages in traditional Web service discovery model for its lacking of QoS supporting, this thesis proposes a new service discovery model SDMQ supporting QoS constraints.4、Technologies of composite service executing. SSPL, a new composite service process language, is defined to overcome the disadvantages of existing composite services process languages which can not adapt to the dynamic variation of Geo-spatial Web Services. An algorithm is described to translate WSCP/R-net model into SSPL. The thesis studies the model of dynamic services selection with QoS global optimization, presenting an algorithm GODSS to resolve dynamic services selection with QoS global optimization in GWSs Composition.5、Design and implement experimental system and representative applications. According to the research findings presented above, we design and implement an experimental system and construct two representative applications to show that our achievements are effective and practical.

针对当前空间信息服务聚合研究中存在的若干不足，本文重点在基于工作流的空间信息服务聚合框架、空间信息服务聚合流程建模和分析技术、空间信息服务QoS模型及应用体系以及空间信息服务聚合流程执行等几个方面进行深入研究，主要工作和创新点包括：1、基于工作流的空间信息服务动态聚合框架：研究了空间信息服务动态聚合和传统工作流应用的不同，在此基础上提出了基于工作流技术的空间信息服务动态聚合实现机制、技术体系和参考模型，为研究空间信息服务聚合的关键技术、开发服务聚合支撑平台以及在此基础上构造特定的空间信息服务聚合应用提供了总体框架和顶层指导。2、空间信息服务聚合流程建模和分析技术：首先基于动态服务聚合流程建模的需求和空间信息服务动态变化的应用实际，从服务聚合的过程维和资源维出发定义了服务聚合流程定义元模型；与之相对应，对基本的WF-net进行扩展，提出服务聚合流程/资源网作为空间信息服务聚合流程的形式化描述模型，有效解决了现有的基于基本Petri网和工作流网的服务聚合建模方法所不能解决的不确定路径选择和服务的动态变化性问题；从流程结构正确性、数据依赖有效性和资源实现有效性三个方面提出了WSCP/R-net健壮性的概念，明确界定了聚合流程正确性的标准，并对WSCP/R-net模型的健壮性分析方法和WSCP/R-net模型的组合特性进行了研究；提出了空间信息服务聚合代数算子并对其性质进行了研究，在此基础上提出了6种聚合流程约简规则，从而可达到优化聚合流程、提高聚合流程执行效率的目的。3、空间信息服务QoS模型和应用体系：从服务本身、网络环境和服务消费者三个层次出发，提出了一个可扩展的空间信息服务QoS模型GSQM，实现了对空间信息服务的度量和评价，并对GSQM不同质量要素信息的客观、公正采集方法进行了研究；研究了空间信息服务聚合流程QoS评价方法，有效支持了空间信息服务聚合流程的执行、监控以及服务选择等操作；针对目前的服务发现模型仅支持服务功能性描述、不能有效满足空间信息服务应用需求的现状，提出了一种新的支持QoS约束的服务发现模型SDMQ，并对模型的实现框架进行了研究。4、空间信息服务聚合流程执行技术：针对现有的服务聚合流程描述语言不能有效满足空间信息服务动态聚合流程描述的特点，基于BPEL4WS提出了一种新的空间信息服务聚合流程描述语言SSPL；研究了满足健壮性要求的WSCP/R-net模型向SSPL的转换算法，在此基础上可以满足用户无显式编码来实现空间信息服务聚合应用的目的；研究了服务动态选择QoS全局优化模型，并在此基础上提出了一种解决服务动态选择QoS全局优化问题的实现算法GODSS.5、基于论文研究成果，设计实现了"空间信息服务聚合实验系统"，并构建了"矿产资源评价"和"城市消防应急响应"两个典型应用案例，对论文所述模型、方法的可行性和有效性进行了验证。

Main points of the thesis are as follows:(1) The main function models and information relations between these models in the CAPP system in the integrated CAD/CAM project are explained, a new process plan design method is mentioned based on analyses of process plan design. This method is based on the process plan prototype, and develops the prototype little by little until the perfect process plan is completed, the prospect of this method is discussed;(2) The feature abstracting rules and methods are studied, a feature coding system is developed based on GT, all the defined feature models are described by the mathematical methods;(3) The integrated method of CAD/CAPP based on features is mentioned, this method defines a feature exchanging model, and develops an interface software to exchange design data into technology data base, this technology data base includes the design and technology information of the parts;(4) The process plan reasoning method based on features is created, this method uses Mycin algorithm to solve the reasoning of the feature process plan. A process plan making system is developed. In this system part process plan is made by the semi-intelligent method, this method uses the feature reasoning, feature process chain searching and man-computer talking together;(5) The main structure of the HOPE system is introduced, a shaft drawing and its process plan made by this system are shown, the data process problem in process drawing making is also discussed;(6) A new method of describing process rule is introduced, this method uses IfThen rules and neural nets weight values together to describe process rules, the BP algorithm is adopted in this method;(7) The optimal machining sequence problem of the process steps on the same fixturing is discussed, optimal algorithms SA is applied to solve this problem, the result shows that this method is more efficient than the traditional method;(8) All jobs in the thesis are summarized. In order to carry out the research in the future, some rational proposals are given.

全文论述的内容主要有下列几个方面：(1)较为系统地阐述了CAD／CAM一体化工程项目中CAPP系统的主要功能模块及其信息流程，在分析工艺设计过程的基础上，提出了基于特征原型的渐进式工艺设计方法，并探讨了该方法的应用前景；(2)研究了零件特征提取的原则和方法，在成组技术的基础上，开发了一套基于特征的分类编码系统，并在提取零件特征的基础上，定义了零件特征的数据模型，开发了基于轴类零件特征的参数化设计系统；(3)研究了基于特征的CAD／CAPP集成的方法，通过定义零件特征数据模型的存储结构，开发了将设计数据转换到工艺数据库中的接口程序，为后续的CAPP系统提供必要的零件形状和工艺信息；(4)研究了基于特征的工艺推理方法，将Mycin算法应用到工艺决策中，开发了基于特征的工艺推理及工艺方案生成系统，在系统中综合运用特征推理、特征加工工艺链查询及人机对话相结合的半智能化方法确定零件加工工艺；(5)介绍了整个HOPE系统的总体结构，通过运行HOPE系统绘出了一轴类零件的零件图，并生成了该零件的加工工艺方案，初步探讨了基于特征的工序图生成技术中数据处理问题；(6)研究了工艺设计过程中知识如何有效表示的问题，提出了将显式的IF-THEN规则表示与隐式神经网络权值表示相结合的工艺知识表示方法，并利用BP算法进行了工艺知识表示的初步研究；(7)研究了工艺设计过程中同一安装下工步优化排序问题，利用神经网络中基于模拟退火的理论来解决该工步优化排序问题，实践证明该方法较传统的算法具有更高的效率；(8)总结了本文所进行的研究工作，为今后进一步开展工作提出了较为合理的建议。

The activated or leached process and their influence elements are studied by 1DREACT software package of coupled mass/heat transfer and chemical reaction dynamics of water-rock interaction, according to the geological and geochemical characters of fine disseminated gold deposits.(1) Water-rock reaction time is not the important influence element of activating gold;(2) At first, activating capability of hydrothermal solution increases with the increasing of total sulfur activity; after lga〓≥-4, the content of activated gold in solution is mainly related to original content of gold in wall rock, and does not visibly dependent on total sulfur activity.(3) It is a complicated nonlinear process of influence of activating gold capacity of hydrothermal solution with the change of temperature, in general, 220 ℃ is most favorable to gold activation.(4) The influence of oxygen fugacity on gold activation has a multiple functions coupling nonlinear effect, in general, Igfo〓=-41 is most favorable to gold activation.(5) Solubility of gold in fluid decreases with the increasing of velocity of flow, the product of velocity and aurous solubility reaches maximum when velocity is 0.2～0.5m〓m〓. yr〓, i. e. this scope of velocity is most favorable to gold activation.

利用1DREACT水-岩相互作用反应-输运耦合动力学软件包，根据微细浸染型金矿床地质地球化学特征，计算机模拟研究了金的活化、浸取过程及其影响因素，发现：(1)金活化过程中水-岩反应时间不是其主要制约因素；(2)热液对金的活化能力开始随总硫活度的增高而增高，当lg a〓≥-4后，热液中活化金的含量将主要与围岩中金的初始丰度有关，而对总硫活度无明显依赖关系；(3)温度对热液浸金能力的影响是一个复杂的非线性过程，总体而言，220℃最有利于金的活化；(4)氧逸度对金活化的影响呈现出一种多因素叠加的非线性效应，总体而言，lgfo〓＝-41最有利于金的活化与浸取；(5)流体中金的浓度随流体流速的加快而降低，流速与金浓度的乘积在流速为0.2～0.5m〓m〓。yr〓时达到极大，即0.2～0.5m〓m〓。yr〓的流速范围最有利于本类矿床的金的活化。

In this thesis, two electrochemical activation methods and two activation solution were used to obtain four types of the activated GC electrodes. Effects of electrochemical activation procedure on the structure, the size, the distribution and the type of electron transfer site on electrode surface have been investigated. Application of electrochemical activation GC electrode has been exploited in electroanalysis of metal ions. Meanwhile, the essence structure and character of electron transfer site of sp2 hybridized carbon material have been explored.

在本论文研究中，通过采用酸性和碱性两种活化溶液，分别以两种不同的电化学活化方法，获得了四种不同的活化电极表面；调查了电化学活化方法对电极表面的电化学活性点的种类、尺度大小、结构以及分布的影响规律；拓展了电化学活化玻碳电极在电分析领域中的应用；探索了sp2杂化类碳材料电极在电子传导点的性质和结构上存在的本质共同点。

The spectral response performance of transmission-mode GaAs photocathode after high-temperature activation and low-temperature activation was measured by the use of on-line spectral response measurement technology, and the integral sensitivity and spectral response performance parameters of the GaAs photocathode after high-temperature activation and low-temperature activation were compared.

利用在线光谱响应技术，对透射式GaAs光电阴极在高温激活和低温激活后的光谱响应特性进行了测试，计算并比较了高温激活和低温激活后阴极的积分灵敏度和光谱响应特性参数。

In accordance with such external technology requirements and based on such presumable precondition that we've found a kind of atomic reciprocal PNT combination A which can be used as PNT activation source accelerating along certain orientation once activated by the so-called PNT activator B, and we can volitionally predominate the magnitude of acceleration and activation rate of PNT activation source by the control of action rate or strength of PNT activator to PNT activation source, the paper introduces macrostructure design of tyre model of PNT engine as following

针对这样的客观技术要求并基于这样的假定事实——"我们己发现一种可用于PNT应激物质源的原子态PNT惠合系α在激励信号β的作用下沿一定方向加速运动，而且我们可以通过直接调控激励信号β对原子态PNT惠合系α的工作强度来控制PNT惠合系α的被激励程度或被激加速度大小和激活率"，本文着重介绍PNT引擎的宏观结构设计——PNT引擎之轮胎结构如下

The process features and shape features of the electronic part are classified and defined, and then the feature model library is built, which enables rapid input of the part information. The rules and methods of stamping process design are summarized to build the stamping process library, so that the stamping process can be designed rapidly and intelligently. Furtherly, the process design rules and methods in process station layout of multi-station progressive die as well as the methods of decompounding and compounding process and the expression method of the process station layout are concluded and summarized, and then the rule library and case library of process station layout are built. Designing the process station layout rapidly is carried out based on rules and cases. At last the rapid design function of process station layout is validated through simulating the rapid designing layout system of multi-station progressive die on Pro/E 3D platform.

主要研究成果有：对电子产品冲压件的工艺特征与形状特征进行了分类和定义，建立了特征模型库，实现了冲压件信息的快速输入；归纳了冲压工艺设计规则和方法，建立了冲压工艺知识库，实现了冲压工艺快速与智能化设计；归纳总结了多工位级进模工步排样中的工序设计原则和方法，工序分解与工序组合方法，工步排样知识的表示方法，建立了工步排样规则库和实例库，利用基于规则和实例的推理方法，实现了工步排样的快速设计；在Pro/E三维软件平台上开发了电子产品多工位级进模工步排样快速设计系统，系统通过实例验证了工步排样的快速设计功能。

The ideal activation process parameter as follow: The nickel sulfate hexahydrate concentration 15g·L~(-1);The Sodium borohydride concentration 15g·L~(-1); The Sodium hydroxide concentration 10-15 g·L~(-1);Hydrochloric acid concentration 10-15 g·L~(-1);The activation time in A solution 9min, the activation time in B solution 90s.

理想的活化工艺参数为：硫酸镍15g·L~(-1)，硼氢化钠15g·L~(-1)，氢氧化钠10-15 g·L~(-1)，盐酸10-15 g·L~(-1)，A液中活化的时间控制在9min左右为最佳，B液中活化的最佳时间为90s。

The ideal high temperature nickel activation process parameter as follow: Nickel acetate concentration 70g·L~(-1);Sodium hypophosphite concentration 70 g·L~(-1);Soakage temperature 40℃;Soakage time 5min ;activation time 30min;Activation temperature 170℃.

理想高温镍活化工艺参数为：乙酸镍浓度70g·L~(-1)，次磷酸钠浓度70 g·L~(-1)，浸渍温度40℃，浸渍时间5 min，活化时间30min，活化温度170℃。

Fostering the concept of multi-culture firmly and mastering the development of advanced culture correctly are conductive to resisting terrorism, separatism of nationalities and ultraism of religion, which is of great academic theoretical, immediate and profound historical si...

牢固树立多元文化的理念和正确把握先进文化的发展方向，有助于在世界范围内自觉地抵制恐怖主义，民族分裂主义和宗教极端主义。不仅具有重大的学术理论意义，而且也具有重大的现实意义和深远的历史意义。

But if anyone walks in the night, he stumbles, because the light is not in him.

11：10 若在黑夜行走，就必碰跌，因为那光不在他里面。