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Specific gene expression of the pro-inflammatory cytokine IL-1β and the type II IL-1βreceptor (IL-1RII, 'decoy receptor') was studied in skin of rainbow trout Oncorhynchus mykiss (Walbaum, 1792) fry during infection with the ectoparasitic monogenean Gyrodactylus derjavini Mikailov, 1975. Cytokine expression was studied in both primary and secondary infections using a semi-quantitative RT–PCR technique.

用半定量RT-PCR的方法，研究初次感染和二次感染体外寄生的单殖吸虫---三代虫后，虹鳟鱼苗的皮肤中促炎症细胞因子IL-1β及IL-1βII型受体（IL-1RII）的特异性基因表达。

In fact, any factor which interfere the formation of the hexameric IL-6 receptor complex might inhibit or antagonize the effect of IL-6. These factors include the IL-6 mutant, sIL-6Rα mutant and soluble gp130, as well as their antibodies.

事实上，任何能干扰IL-6信号转导中异六聚体复合物形成的因素都可能抑制或拮抗IL-6的作用，其中包括IL-6的突变体分子、sIL-6Rα的突变体分子和可溶性gp130分子以及它们的抗体。

The results of respiratory mechanics, homodynamic mechanics,aterial blood gaS, and inflaInInatory factors [TNF- Q, IL-l fl, IL-6,IL-l0, and adrenomedulin] which detected in animal serumand bronchial alveolar lavage fluid obtained from tiP lObe,heart lobe, and diaPhragIn lobe of right lung seParate1y in the mongreldogs were measured before and after lung injury (including receivinglung protective ventilation).

本实验证明了 loS肺内／肺外不同源性 ARDS动物模型的差异性，而且AnDS的肺部病变存在不均一性和多形性的特点，对有关ARDS进行性低氧血症的发生机制提出了肺动静脉可能存在类似于右一左分流的肺内分流现象，以及因肺内分流而导致严重通气／血流比例失调的解释。发现小潮气十PEEP通气对肺内源性 ARDS疗效不佳，而俯卧位＋小潮气－I－ PEEP通气对肺内／肺外不同源性ARDS均有较好的疗效。。

2The elevated serum IL-10 and abnormal expression of IL-1β,TNF-αand IL-10 mRNA could make the inflammation incontrollable, and they were involved in the initiation and development of renal injury associated with AHNP in rats.

2AHNP大鼠血清IL-1β升高、肾组织IL-1β、TNF-αmRNA表达明显增强和IL-10mRNA表达明显减弱，IL-1β、TNF-α、IL-10共同参与了AHNP中肾损害的发生、发展。

Methods: 5% propranolol emulsion was applied externally on the back of a guinea pig\' s ear to produce the psoriasis-like dermatitis model to observe the effects of Baibi ointment on the histopathological changes of the model.Radioimmunoassay was used to observe the levels of cytokines like IL-2、IL—6 and IL-8, and the effects of the ointment to the cytokines. MTT method was used to study the effects of the extracts of the Baibi Formula and the extracts of its main components Huangjing , Kushen , Dahuang ,Huangbai, to the multiplication of HaCaT cells—one of the Malpighian cell line with and without stimulation of TNF-α.

实验采用5%心得安乳剂建立豚鼠银屑病样皮炎模型，观察白疙软膏对豚鼠银屑病样皮炎模型组织病理改变的影响；采用放射免疫法检测豚鼠银屑病样皮炎模型皮损中细胞因子IL-2、IL-6、IL-8的水平，观察白疕软膏对豚鼠银屑病样皮炎模型皮损中细胞因子的影响；采用MTT法研究了中药白疕方提取液及白疕方主要组成药物大黄、黄柏、黄精、苦参提取液对角质形成细胞系HaCaT细胞增殖的影响及对TNF-α刺激后的角质形成细胞系HaCaT细胞增殖的影响。

IL-6 might participate the patho-physiology process of EH.; Up-regulating expression of IL-6 mRNA may be one of the mechanisms increasing protein IL-6 in peripherial blood of EH patient.

IL-6可能参与了原发性高血压的病理生理过程，外周血单个核细胞的IL-6 mRNA表达上调可能是原发性高血压患者外周血IL-6蛋白水平升高的机制之一。

Results(1) Group of electroacupuncture in Shu and dense wave can significantlyreduce the degree of ankle swelling(P＜0.05, P＜0.01), which shows thatelectroacupuncture has obvious anti-inflammatory and repercussive roles;(2) Theresults of HE staining showed that group of electroacupuncture in Shuand dense wave can significantly reduce inflammatory cell infiltration,inhibit synovial cell proliferation, and decrease proliferation of granulationtissue in rats joints;(3) group of electroacupuncture in dense-wave can increase the pain thresholdof experimental rats (P＜0.05, P＜0.01), reduce the content of peripheral painmediums, such as K~+, DA and 5-HT(P＜0.05, P＜0.01), which shows thatelectroacupuncture has significant analgesic effect;(4) In the local lesion of joints, electroacupuncture can significantly reducethe content of IL-1β, IL-8, TNF-a, increase IL-4 content, decrease theexpression of COX-2mRNA, and significantly promote the expression ofHSP-70 protein in synovial tissues of acute gouty arthritis rats (P＜0.05,P＜0.01),thus restrain the occurrence of synovial tissue inflammation.

结果：(1)电针疏密波组能显著减轻踝关节肿胀度(P＜0.05，P＜0.01)，表明电针有明显的抗炎消肿作用；(2)HE染色显示：电针疏密波组可使大鼠关节炎症细胞浸润明显减轻，滑膜细胞增生明显被抑制，肉芽组织增生明显减少；(3)电针密波组能提高实验性大鼠痛阈(P＜0.05，P＜0.01)，降低外周疼痛介质K~+、DA、5-HT的含量(P＜0.05，P＜0.01)，表明电针有明显的镇痛作用；(4)在病变关节局部，电针能显著降低急性痛风性关节炎大鼠滑膜组织IL-1β、IL-8、TNF-α含量(P＜0.05，P＜0.01)，升高IL-4的含量(P＜0.05，P＜0.01)，并降低关节滑膜内COX-2mRNA的表达(P＜0.05，P＜0.01)，可促使急性痛风性关节炎大鼠滑膜内HSP-70蛋白表达显著增加(P＜0.05，P＜0.01)，从而抑止滑膜组织炎症发生。

Objectives:Through the detection of the expression level of interleukins-1β(IL-1β), matrix metalloproteinase 9(MMP-9) and nuclear factor kappa B in Synovium and the detection of the concentration of IL-6 and TNF-αin serum of collagen induced arthritis Wister rat, to investigate the relationship between IL-1β、MMP-9、NF-κB and arthritis index in the development of arthritis,and to understand the pathology of synoviocyte.This may provide an experimented proof for the diagnosis of clinical rheumatical arthritis. Methods: Thirty male Wistar rats were randomly divided into two groups,namely the model controlled group and the normal controlled group,three subgroups were randomly divided in model group and controlled group separately.

目的：通过对白细胞介素1β，基质金属蛋白酶-9，转录因子核因子κB在胶原性关节炎大鼠滑膜细胞表达水平的观察，同时监测同期血清细胞因子IL-6和TNF-α的浓度，旨在探讨白细胞介素1β，基质金属蛋白酶-9，转录因子核因子κB与RA发生发展及其与关节指数之间的相关性，了解炎性病变关节滑膜细胞的病理生理状态，进一步为类风湿关节炎的临床治疗提供实验依据。

CINC-2、LIX、TNF-α、VEGF were in a persistent heighten tendency in the model groups during the whole period of exeriment while CINC-3、GM-CSF、IFN-γ、IL-1β、Leptin heightened gradually and Fractalkine、IL-6、IL-1αfluctuated. MCP-1 increased significantly at third week but surgeless after that. MIP-3a、TIMP-1 changed little during the whole period.

在大鼠动脉壁泡沫细胞形成的整个过程中，4种细胞因子处于持续升高趋势，包括CINC-2、CNTF、LIX、VEGF；6种呈现逐渐升高趋势，包括CINC-3、GM-CSF、IFN-γ、IL-1β、Leptin、β-NGF； 5种因子包括Fractalkine、IL-6、IL-1α、IL-10、TNF-α处于波动状态；MCP-1在3周时明显升高，其它时相点变化幅度不大，MIP-3a、TIMP-1、IL-4在整个病变过程中变化幅度始终较平稳。

Further,with indirect immunohistochemistry technique,CD25(IL-2 receptor or IL-2R) cross-reaction has been identified on lymphocyte membrane of Ctenophaxyngodon idellus and Trionyx sinensis using mouse monoclonal antibody directed against Human Leucocyte Differentiation Antigen CD25(IL-2R).

进一步用抗人白细胞分化抗原CD25(IL-2受体，简称IL-2R)单克隆抗体进行免疫组化交叉反应提示草鱼、中华鳖淋巴细胞膜上含有与人类IL-2R类似功能和结构的物质。关键词：白细胞介素-2；白细胞介素-2受体；发育和比较免疫学；草鱼；中华鳖

The system can be widely used in belt weighing and batching process control,etc.

介绍了基于智能模糊控制的嵌入式配料系统的设计方法，对模糊PID控制过程和系统调零作了重点的讨论，同时给出了PID控制的程序流程图和系统定长调零子程序。

"I dunno," she answered,"but if you show me aroun', I'll recognize it from the lighthouse just outside the porthole."

"我不知道，"她回答说，"如果你能带我转转，我能认出来的，因为灯塔就在舷窗外。"