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M{rX*o0 OBJECTIVE: To investigate the effects of neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI) on smoke inhalation pulmonary injury in rats. METHODS: Forty healthy male SD rats were randomly divided into three groups: control group (n=8), smoke inhalation model group (n=16) and 7-NI treatment group (n=16). After reproducing the smoke inhalation model, to the 7-NI treatment group rats 7-NI (20 mg/kg in 2 ml arachis oil) was administered by intraperitoneal injection, while in the control group and the model group, 2 ml arachis oil was administered by intraperitoneal injection.

探讨神经型一氧化氮合酶抑制剂7-硝基吲唑(7-NI)在烟雾吸入性肺损伤中的作用。40只SD雄性大鼠被随机分为正常对照组(n=8)、烟雾吸入性肺损伤模型组(n=16)和7-NI治疗组(n=16),建立烟雾吸入性肺损伤模型。7-NI治疗组在致伤后立即腹腔注射7-NI 20 mg/kg(溶于2 ml花生油中);正常对照组及模型组腹腔注射2 ml花生油。

After 24 h reperfusion, these values were 403, 155 and 293 for PO2/FiO2; 3.7, 11.0 and 6.7 for lung injury pathology score; 3.7, 6.4 and 5.2 for wet-to-dry ratio; 2,3, 7.2, 5.0 for MPO activity; 0.7, 1.5, 1.2 for MDA activity in lung tissue, 2.5, 5.5, 4.6 for MDA in serum, 29.3, 43.1, 32.1 for CINC activity.

再灌注24 h,各组PO2/FiO2分别为403, 155,293;肺损伤病理评分为3.7, 11.0, 6.7;W/D分别为3.7, 6.4, 5.2;MPO活性分别为2.3, 7.2, 5.0 U·g-1;MDA肺组织中活性为0.7, 1.5, 1.2 nmol·mg pro-1;血清中活性为2.5, 5.5, 4.6 nmol·mL-1;CINC活性分别为29.3, 43.1, 32.1 pg·mg pro-1。

Additional pathologic findings included: chronic peptic duodenitis (6 out of 17, 35%), active duodenitis (1 out of 17, 6%), and celiac-like features (2 out of 17, 12%) in the duodenum; chemical gastropathy (3 out of 18, 17%), active chronic gastritis without Helicobacter pylori (2 out of 18, 11%), and erosion (1/18,6%) in the stomach; reactive epithelial change (3 out of 7, 43%), active esophagitis (3 out of 7, 43%), ulceration (2 out of 7, 29%), and erosion (1 out of 7, 14%) in the esophagus. Serum MPA levels were available in 7 patients, 6 of whom had abnormal duodenal apoptotic counts.

其他病理特点包括:十二指肠:慢性消化性十二指肠炎(17例中有6例,35%)、活动性十二指肠炎(17例中有1例,6%)和乳糜泻样特征(17例中有2例,12%);胃:化学性胃病(18例中有3例,17%)、慢性活动性胃炎且无HP感染(18例中有2例,11%)和糜烂(18例中有1例,6%);食管活检:反应性上皮改变(7例中有3例,43%)、活动性食管炎(7例中有3例,43%)、溃疡(7例中有2例,29%)和糜烂(7例中有1例,14%)。7例患者提供了其血清MPA浓度,其中有6例的十二指肠细胞凋亡计数异常。

Meanwhile, the complications and prognosis of the patients receiving operation within l or 2 weeks after onset or during the infection were compared. Results In the 53 patients with ESAP, 43 patients (81.1%) had multiple organ dysfunction, 41(77.4%) had acute respiratory distress syndrome, 38 (71.7%) had abdominal hyperpiesia, 26(49.1%) had acute renal dysfunction. ARDS, abdominal hypertension and ARD were the most common complications in ESAP. Forty-five patients (84.7%) suffered form ESAP, and eight of them died during the hospital stay.

结果 在53例ESAP中,43例(81.1%)并发多脏器功能障碍,急性呼吸窘迫综合征41例(77.4%)、腹内高压38例(71.7%)和急性肾功能障碍26例(49.1%)是最常见的并发症。53例ESAP治愈45例,总治愈率为84.7%,6例1周内行手术治疗、7例7~14 d手术、21例感染期手术、19例病程中未行手术治疗,治愈率分别为66.7%、71.4%、85.7%和94.7%。

Constituting dicycle; 2. region selectively reducing six-membered ring ketocarbonyl radical; 3. introducing 7alpha-hydroxy group; 4. Aldol reaction to introduce side chain and obtain 8alpha-hydroxy group; 5. oxidizing the position 7 hydroxy group into ketone; 6. turning the configuration of the position 7 hydroxy group; 7. glycosidating the position 7 hydroxy group; and 8. eliminating protecting group to obtain the target compound.

该方法包括如下步骤:(1)双环的构建;(2)区域选择性还原六元环酮羰基;(3)7α-羟基的引入;(4)Aldol反应引入侧链,同时得到8α-羟基;(5)7位羟基氧化为酮;(6)7位羟基构型的翻转;(7)7位羟基的糖苷化;(8)脱除保护基得到目标化合物。

Both of the thermophiles were motile by means of lophotrichous flagella and had high growth rate on medium containing cellulose. Optimal growth occured at 60℃ for the two thermophiles and at PH 7. 5 for Y, PH 7. 37. 5 for W strain. Y strain produced yellow pigment in cellulose medium and had yellow-colored, round or watery colonies in cellulose agar. The colonies of W strain were white -colored and similar in form to that of Y strain. The mesophile, Clostridium sp. B, was motile with peritrichous flagella. The colonies grown on cellulose agar were white and round with slightly undulate margins. The optimal growth temperature and PH of B strain were 40℃ and 7. 0-7. 2, respectively. All of the three Clostridia fermented varieties of carbohydrates and in cellulose media produced the similar end-products: CO〓H〓, ethanol and acetic acid. The DNA compositions were 34 mol% for Y and B, 35 mol% for W strain.

嗜热菌y与w在含纤维素的培养基中生长迅速,其最适生长温度均为60℃;最适PHy为7.5,w为7.3-7.5.y菌在纤维素培养基中产生黄色,在纤维素琼脂中菌落为黄色并呈圆形或流动粥样。w菌落为白色,但形状与y菌类似,嗜温菌B在纤维素琼脂上菌落为白色,圆形,边缘呈微小波状,最适PH与温度分别为7.0-7.2和40℃,三支菌都可发酵多种碳水化合物,且在纤维素培养基中产生同样的产物:CO〓H〓,乙醇和乙酸,三者DNA组成分别是y为34mol%,w 35mol%,B 34mol%。

Meanwhile, Michael Fuller put together a run through the one-loss side by defeating Monday 7-5, Younger Chapman 7-1, Montez Lloyd 7-1, Charles Jones 7-3, and Peaches Fuller 7-6 to earn a rematch with Winters.

与此同时,迈克尔更充分地放在一起运行,通过一个损失方面战胜了周一7月5日,年轻的查普曼7月1日, montez劳合社7月1日,查尔斯琼斯7月3日,和桃子更详尽的7月6日,以赚取rematch与冬天。

The protease activity in foregut was higher than that of midgut in an acidic condition at pH 5.0-5.8, while in an alkalescence condition at pH 7.0-8.6, the protease activity was higher in midgut than that in foregut. The lipase activity of foregut was high and stable in two pH ranges: 4.2-5.0 and 6.2-7.0, and that of midgut was high at pH 3.8, while the lipase lost enzyme activity at pH over 9.0. The amylase activity was high and stable at pH 6.6-7.4 in both foregut and midgut. The cellulase activity of foregut and midgut was high and stable at pH 6.2-7.4 and 5.4-7.0 respectively.

刺参前肠蛋白酶活力在酸性环境下较中肠高,且在反应pH为5.0-5.8之间酶活力相对稳定,而中肠蛋白酶活力在碱性环境下较前肠高,且在反应pH为7.0-8.6之间酶活力相对稳定;刺参前肠脂肪酶活力随着pH的升高出现两个相对稳定的峰值,分别为4.2-5.0和6.2-7.0区间,中肠脂肪酶活力在pH为3.8时达到最大值,而在pH超过9.0明显失活;刺参前肠和中肠淀粉酶活力在pH变化时表现出相似的变化趋势,在反应pH为6.6-7.4之间酶活力较高且相对稳定;刺参前肠和中肠中纤维素酶活力在pH变化时反应不一致,前肠淀粉酶在反应pH为6.2-7.4之间酶活力较高且相对稳定,中肠纤维素酶活力在反应pH为5.4-7.0之间酶活力较高且相对稳定。

Chad Stokes made his way thru the bottom half of the bracket on the winner side with ease facing and defeating Sherri Reeves 7-0; Daniel Pittman 7-6; Bill Allen 7-2; Rocky Guell 7-1; BJ Hucks 7-4 before facing Farias in the Finals.

乍得斯托克斯他的方式,通过底部的一半的支架上赢家方轻松面对和战胜雪莉里维斯7-0 ;丹尼尔皮特曼7月6日;条例草案李鹏飞7月2日;洛基guell 7月1日; hucks北京7月4日前面临的法利阿斯在决赛。

After standard fire exposure test, the bending properties of glulam decreased with the fire exposure time increasing. The values of MOE and MOR decreased respectively from 4.1 GPa to 2.5-3.8 GPa and 48.2 MPa to 27.1-36.6 MPa for China fir glulam, from 5.3 GPa to 3.7-4.6 GPa and 54.8 MPa to 23.0-39.4 MPa for Japanese cedar glulam, from 5.3 GPa to 3.4-4.7 GPa and 51.4 MPa to 21.8-38.6 MPa for Taiwania glulam, from 7.7 GPa to 6.6- 6.9 GPa and 62.7 MPa to 33.2-40.8 MPa for Douglas-fir glulam, from 6.0 GPa to 4.4-5.3 GPa and 58.9 MPa to 26.4-42.1 MPa for Southern pine glulam.

经燃烧试验后,集成材之力学性质上,集成材之抗弯强度会随燃烧时间之增加而降低,其中,杉木集成材之MOE值由4.1 GPa降至2.5 - 3.8 GPa,MOR值由48.2 MPa降至27.1 - 36.6 MPa;柳杉集成材之MOE值由5.3 GPa降至3.7 - 4.6 GPa,MOR值由54.8 MPa降至23.0 - 39.4 MPa;台湾杉集成材之MOE值由5.3 GPa降至3.4 - 4.7 GPa,MOR值由51.4 MPa降至21.8 - 38.6 MPa;花旗松集成材之MOE值由7.7 GPa降至6.6 - 6.9 GPa,MOR值由62.7 MPa降至33.2 - 40.8 MPa;南方松集成材之MOE值由6.0 GPa降至4.4 - 5.3 GPa,MOR值由58.9 MPa降至26.4 - 42.1 MPa。

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