靶

Thus, the development of an effective treatment tosolve the chemoresistance of pancreatic cancer remains an urgent task.

近年来随着分子生物学研究的深入发展，以凋亡抑制蛋白为靶点的基因治疗备受关注，目前的实验研究已经取得了初步的成效和进展，可能为有效提高胰腺癌治疗效果提供了一个新的方向。

Objective: To explore the role of hypoxia-inducible factor-1α(HIF-1α) in formation of multidrug resistance induced by microenvironment and to find a new and effective molecular target on preventing and reversing chemoresistance in hepatocellular carcinoma.

目的探讨缺氧诱导因子1α(HIF-1α)在微环境诱导的肝癌多药耐药表型形成过程中的作用和地位，并为预防和逆转肝癌耐药提供有效的新的分子靶点。

A deficiency in cholinergic neurotransmission is considered to be one of the major causes of memory impairments in patient.

致病机理之一是在神经冲动传输过程中缺乏乙酰胆碱，乙酰胆碱酯酶能分解乙酰胆碱，因而成为一个被广泛关注的靶分子。

whole brain and most regional metabolism decrease significantly during midazolam anesthesia. thalamus, left prefrontal cortex and cingulated gyrus are most sensitive to midazolam and they may be the primary targets in midazolam anesthesia.

全脑及脑内多数区域cmglu在咪唑安定麻醉后可显著降低，丘脑、左前额叶和扣带回对咪唑安定麻醉更为敏感，可能是咪唑安定麻醉在脑内作用的主要靶区。

Small interference RNA homolog to silenced gene in sequenceis indued into cell to clearage the mRNA of target gene. Many studies havedemonstrated that RNAi is an effective tool for gene diagnosis and gene therapy.

我们根据文献报道选择EZH2基因cDNA的461～481碱基为靶序列，构建EZH2-siRNA表达质粒，并研究其对人膀胱癌EJ细胞EZH2基因表达及生长抑制作用。

Collecting a total of 102 cases(107eyes) of pations with traumatic optic neuropathy that underwent edoscopic optic nerve decompression surgery during December 1999 - April 2008 line,retrospective analysis of CT performance for the optic canal and paranasal sinuses,and Comparison of them with surgical results.102 cases of patients performed routine and coronal axial sinus CT scans,the optic canal zone wi th thin target scan,line of nasal tip and the anterior clinoid process connection as baseline for axis scan,and the vertical line of "bed nasal line" as baseline for coronal scan.

方法收集1999年12月-2008年4月间在青医附院耳鼻喉科行鼻内镜下视神经减压手术的外伤性视神经病患者的病例，共102例(107眼)，回顾分析其鼻窦及视神经管CT表现，并查看手术记录描述，将CT结果与术中所见情况进行对比分析。102例患者术前常规行轴位及冠状位鼻窦CT扫描，视神经管区行薄层靶扫描，以骨性鼻尖与前床突的连线为轴位扫描基线，以&床鼻线&的垂直线为冠状位扫描基线。

The recombinant proteins were purified according to the protocol of Ni-NTA Agarose and detected by SDS-PAGE, and TLC. Western blotting was used to identify their immunoreactivities with the serum of patient with clonorchiasis.

寄生性蠕虫以胞质GSTs为主，参与对由虫体代谢和宿主免疫系统所产生的脂质过氧化物和细胞毒性的羰基的解毒，对虫体的生存起重要的作用，是免疫疗法、化学疗法和免疫诊断潜在的靶标。

objective to screen functional gene through construction of the cdna library of adult clonorchis sinensis.

目的 通过建立华支睾吸虫成虫cdna文库，筛选其功能基因，以研制华支睾吸虫的药物靶标。

The coagulative necrosis appeared in the target region resulted from the effect of HIFU on biological tissues.

肝脏靶区出现凝固性坏死是聚焦超声束作用于生物组织的结果。

By using the experiment animal and target animal to establish the pathology model of Colibacillosis, the experiment also measured out that matrine can effectively reduce the death rate of chicken caused by the Escherchia coli at the dose of 100mg/kg, showing that matrine has a good prohibiting effect on the Escherchia coli.

本实验还通过对实验和靶动物制造大肠杆菌病的病理模型，测定出苦参碱在100mg／kg的剂量下对大肠杆菌所致雏鸡死亡率有显著的降低作用。

I'm strongly against the death penalty — it's an eye for an eye.

我不赞成死刑——这是以牙还牙的报复行为。

And to get you the support you need, we're enlisting all elements of our national power: our diplomacy and development, our economic might and our moral suasion, so that you and the rest of our military do not bear the burden of our security alone.

并给你们所须的支援，我们正徵召国家所有各种的力量：我们的外交及发展，我们的经济力量与道德劝说，所以你们与其他军人不须要孤独地负起国家安全的责任。