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角叉胶

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Results The extract remarkably inhibited the contraction caused by histamine and acetylcholine, as well as the ovalbumin sensitized allergic constriction of isolated ileum smooth muscle of guinea pigs. It could inhibit the increase of capillary permeability induced by acetic acid in mice, inhibit the mice paw edema produced by carrageenin and reduce the production of PGE 2 in inflammatory tissues.

结果:辛夷二氯甲烷提取物对组胺、乙酰胆碱(Ach引起的豚鼠离体回肠收缩具有显著的抑制作用,并能抑制卵白蛋白所致的豚鼠离体回肠过敏性收缩,对HAc引起的小鼠腹腔毛细血管通透性增高具有抑制作用,能显著抑制角叉菜胶引起的小鼠足肿胀,并减少前列腺素E2(PGE2)在炎症组织中产生。

RESULTS Xiaocuoling at the concentration of 2.5、5.0、10.0g.kg-1 obviously inhibited the paws swelling induced by carrageenin in mice and the granuloma with cotten pellet in rats,decreased the penetration of blood capillary caused by histamine,increased the activity of peroxide hydrogenase in RBC,reduced the reaction of the torsive body induced by acetic acid in mice,and had no effects on the serum concentrations of testosterone of serum in male rats.

结果:消痤灵颗粒 2.5、5.0、10.0g.kg-1可显著抑制角叉菜胶所致的小鼠足趾肿胀和大鼠棉球肉芽肿,降低由组胺诱导的小鼠皮肤毛细血管通透性的增加,提高红细胞过氧化氢酶的活力。对乙酸致小鼠扭体反应有抑制作用。对雄性大鼠血清睾酮含量无影响。

Methods Animal inflammatory models were established by injection of dimethylbenzene for mice ear swelling, carrageenin for rat footpad, cotton pellet wool for rat granuloma respectively. The content of prostaglandin E2(PGE2) and leukotriene B4(LTB4) from peritoneal macrophages were measured by RIA and RP-HPLC respectively.

采用二甲苯诱导的小鼠耳肿胀、角叉菜胶诱导的大鼠足肿胀、棉球诱导的大鼠肉芽肿模型观察TFC的抗炎作用;分别采用放射免疫法和反相高效液相色谱法检测TFC对大鼠腹腔巨噬细胞产生前列腺素E2(PGE2)和白三烯B4(LTB4)的影响。

The Nvzhendan Granula antiinflammatory effect was demonstrated in rats using inflammatory models including auricle edema induced by xylene in mice,and paw edema induced by carrageenin.

采用醋酸和热板致痛法观察复方女真丹颗粒的镇痛作用;采用二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足肿胀炎症模型观察复方女真丹颗粒的抗炎作用。

Corton oil,inhibit the rat foot swelling induced by carrageenin,It could increase the mice pain threshold induced by hot plate and inhibit theobviously anti-inflammatory and analgesic effects.

可明显抑制巴豆油所致小鼠耳廓肿胀和角叉菜胶所致大鼠足跖肿胀,能明显提高热板法小鼠痛阈,对甲醛疼痛模型小鼠舔足反应

Results The decoction intragastric injection showed a marked suppressive effect on the normal and adranalectomized rat's hind paw oedema induced by carrageenin. In addition, at the dosage of 150g/kg, Smilax china ig reduced the content of PGE2 in inflammatiory tissue and the content of NO, MDA in serum, and the content of NO in inflammatory tissue at the dosage of 90, 150g/kg.

结果:拔葜灌胃给药能明显抑制角叉菜胶所致正常大鼠和去肾上腺大鼠足肿胀,150g/kg拔葜可降低肿胀足爪组织中PGE2及血清中NO、MDA含量,90、150g/kg拔葜可降低肿胀足爪组织中NO含量。

Result: Xinhuang Tablet had very significant inhibition on acute and chronic inflammation in model of ear edema induced by croton oil in mice, paw swelling induced by carrageenin in rats, granuloma induced by cotton pellet in rats and very significant analgesic effect on thermal and chemical stimulation in model of writhing body response induced by acetic acid in mice and tail flicking in rats.And at the same doses, Xinhuang Tablet hadn't significant difference from ig administration.

结果:新癀片外涂给药对小鼠耳肿、大鼠角叉菜胶足肿、棉球肉芽肿等急、慢性炎症有非常显著的抑制作用;对大、小鼠水浴甩尾、小鼠醋酸扭体等温热刺激、化学刺激引起的疼痛有非常显著的镇痛作用,且在相同剂量下,外涂给药和ig给药的作用无明显差异。

Methods Antipyretic action of CSC was observed on rabbit fever models induced by lipopolysaccharide and rat fever models induced by baker's yeast. Rat models with pedal swelling induced by carrageenin, mouse models with auricle swelling induced by dimethylbenzene and mouse models with celiac capillary hyperpermeability induced by acetic acid were used to observe the anti- inflammatory action of CSC. Its acute toxicity in mice was also evaluated.

方法]采用细菌脂多糖致家兔发热、啤酒酵母致大鼠发热动物模型,观察穿心莲软胶囊的解热作用;采用角叉菜胶致大鼠足肿胀、二甲苯致小鼠耳肿胀和醋酸致小鼠腹腔毛细血管通透性增加的动物模型,观察穿心莲软胶囊的抗炎作用,并对小鼠进行该制剂的急性毒性试验。

Pae (25-100mg/kg, ip) not only inhibited the swelling of mouse pinnea induced by xylene in a dose-dependant manner, but also suppressed the edema of rat hind paw induced by injection of 1% carrageenin at a higher dose (100 mg/kg, ip).

Pae(25-100mg/kg,ip)可剂量依赖性地抑制二甲苯所致的小鼠耳肿胀,高剂量(100mg/kg,ip)时可抑制角叉菜胶所致的大鼠足跖肿胀。

Results All Qianliean groups could inhibit the inflammation caused by carrageenin, increases the density of prostate tissue lecithin, and could suppress the lint ball granuloma formation obviously and has the obvious inhibitory action on the blood capillary permeability increasing.

结果 前列安颗粒小、中、大剂量均可抑制角叉菜胶所致大鼠前列腺非细菌性炎症,增加前列腺组织内卵磷脂小体密度,并可明显抑制棉球肉芽肿形成;对二甲苯所致小鼠炎症均有明显抑制作用;可明显抑制0.6%醋酸所致小鼠腹腔毛细血管通透性的增加。

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