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ZO1 and Cx26 expressions in the sensory epithelium have different location and were not overlapped. Tight junctions maintain the ion barrier between the endolymph and perilymph,and gap junctions take part in ion transportation.

Cx26和Cx30分布在基底膜的各种支持细胞,在感觉毛细胞没有表达;此外,该研究发现Cx26和ZO1在耳蜗内具有不同的表达方式和表达部位,紧密连接ZO1在网状板面构成了毛细胞之间或与其支持细胞之间的离子屏障,阻止内、外淋巴之间的相互流通,保持了各自之间的离子平衡;缝隙连接则表达在基底膜的深层,参与离子转运。

All the patients had mucocutaneous pigmentation, gastrointestinal polyps, abdominal pain, anemia, and so on. All the patients were examined by endoscopy, polyps were removed by electrocautery snear under endoscopes, and 3 cases underwent enterotomy operation because of intestinal obstruction and intussusception.

结直肠癌组织和正常结肠黏膜广泛表达ER-β,正常结肠上皮主要呈核染,而结直肠癌组织主要为胞浆染色,ERβ在结肠上皮细胞表达,尤其在处于腺体底部的结肠隐窝大量表达,ERβ还可在内皮细胞和肌细胞上表达

Although overexpression of Hspa5 does not cause detectable defects, its knockdown by injecting Hspa5 morpholino antisense oligonucleotides results in slower epiboly during gastrulation and dorsalized phenotypes at 24 hpf, including smaller and curled tail and absence of caudal ventral fin. When Hspa5 expresison in embryos is knockdown, the expression of the dorsal markers gsc and ntl is enhanced while the expression of ventral markers is reduced.

尽管在胚胎中过量表达Hspa5对胚胎发育没有明显影响,但是利用反义吗啉环寡核苷酸抑制胚胎中Hspa5的表达会导致胚胎外包变得缓慢,24hpf出现尾部变细或卷曲、缺少腹鳍等背部化的表型,同时gsc和ntl等背部标记基因的表达增强,但eve1等腹部标记基因的表达减弱。

The expression level of cAPN mRNA in lung,glandular stomach and jejunum were higher than that in other tissues,and the expression level of it in bursa of Fabricius and spleen were lower than that in other.

结果显示,随着日龄增加,肝、脾、法氏囊、回肠、肾等组织中的cAPN表达量相对稳定,肺、腺胃、空肠等组织中的cAPN表达量呈现持续下降趋势,而十二指肠中的cAPN表达量持续上升,但盲肠、空肠中的cAPN表达量规律性不强且波动较大。

The results show that the CD29, CD49, CD90 express in the gonium and the primary spermatogenous, but there are not expression in the oocyte, the second spermatogenous and the spermatocyte.

研究结果表明,CD29, CD49, CD90在雌性生殖腺各级卵母细胞中均不表达,位于生殖褶边缘的性原细胞中可见表达;在雄性生殖腺的初级精原细胞中表达,但在成团分布的次级精原细胞、各级精母细胞中均未表达

Result The inhibitory effect on pulmonary metastasis of transplanted tumor were 46.36%, 32.73%, 18.2% in the Runing granule preparation group, warming kidney group, dispersing liver and promoting blood circulation group respectively. There wasn't significant difference between Runing granule preparation group and CTX group (50.91%). The expression of VEGF was dropped in Runing grannie preparation group and dispersing liver and promoting blood circulation group. The expression of TIMP-1mRNA was up-regulated in Runing Granule group and warming kidney group. The expression of MMP-9 was dropped in Runing granule preparation group and warming kidney group.

乳宁冲剂组及拆方温肾组、疏肝活血组对裸鼠乳腺癌移植瘤的肺转移抑制作用分别为46.36%、32.73%、18.2%,乳宁冲剂组作用与CTX组(50.91%)比较无显著差异;而乳宁冲剂组、疏肝活血组均可下调肿瘤VEGF蛋白表达;乳宁冲剂全方、温肾方可明显使TIMP-1mRNA的表达升高,MMP-9表达下降;对MMP-9/TIMP-1蛋白表达比值影响以温肾组下降最明显。

After spinal nerve injury, somas of the primary sensory neurons in segmental DRG show hyperexcitability, characterized with spontaneous firing .

由于HCN2、3、4在所有DRG神经元上都有表达,而小神经元上没有HCN1表达,因此在大、中神经元上HCN的四种亚型都有表达,其中以HCN1为主;在小神经元上只表达三种HCN亚型。

Objective To study the significance of expression of cyclooxygenase-2(COX-2)and vascular endothelial growth factorin breast cancerand its correlation.Methods Paraffin imbedding tissues from 60 cases with BC were detected for expression of COX-2 and VEGF by immunohistochemistry,the relationship of its expression with clinical pathological parameters were analyzed.

目的 探讨环氧化酶-2(COX-2)和血管内皮细胞生长因子在乳腺癌组织中的表达及其表达之间的关系方法 S-P免疫组织化学方法检测60例乳腺癌石蜡包埋组织中COX-2和VEGF的表达,分析其表达之间的关系及其与临床病理参的关系。

Results 1.VEGF-C expression and MVD in epithelial ovarian carcinoma were higher than those in normal ovarian tissue (P.05),TSP-1 expression were lower than those in normal ovarian tissue (P.05);2.In epithelial ovarian carcinoma tissue,VEGF-C expression and MVD increasing according to progression of the FIGO phase but TSP-1 expression decreasing according to progression of the FIGO phase.

结果 卵巢上皮癌中VEGF-C表达及MVD均明显高于正常卵巢组织(P.05),TSP-1表达低于正常卵巢组织(P.05);卵巢上皮癌组织中,VEGF-C表达及MVD随国际妇产科联盟分期的进展而增高(P.05),TSP-1表达随FIGO分期的进展而降低(P.05)。

In infundibulum and ampulla, the mPGES-2 staining from days 3 to 5 was very weak. During estrous cycle, mPGES-2 immunostaining in infundibulum was weak at diestrus and comparatively stronger at estrus. In ampulla, the immunostaining was nagtive in diestrus and weak in estrus.

发情周期中,mPGES-2 蛋白在发情间期伞部弱表达,在发情期伞部较强表达;在发情间期壶腹部不表达,在发情期壶腹部弱表达,与Western blot 检测整个输卵管的结果基本一致。

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