药物

In order to find screening rules suitable for lead compounds of pesticide,five descriptors:logarithm of partition coefficient of octanol/water,relative molar weight,number of hydrogen-bond donors,number of hydrogen-bond acceptors,polar surface areaand carcinogenic and mutagenic toxicities of 242 fungicides,512 herbicides and 399 insecticides were calculated and analyzed.

1996年，Lipinski通过对2000多种口服药物进行分析，提出了用于药物分子筛选的&5规则&，即化合物疏水常数(CLogP≤5或MLogP≤4.5)，相对分子质量不大于500，氢键给体数不大于5和氢键受体数不大于10[1]。2003年，Andrew等报道了从高通量筛选结果中获取先导化合物的规则：化合物疏水常数≤3，相对分子质量小于450[2]。

The good results can be obtained with the newalgorithm; the local minimal can be avoided in some degree. In this paper, neural networks also were applied to quantitativestructure-property relationships analysis:1Studies on the toxicity of aniline, nitrobenzene and phenol derivatives and their structures.2 Studies on HEPT compounds for their anti-aids.3 Studies on nitrogen mustards and 2-formylpyridine thiosemicarbazone compounds for their anti-cancer.4 Studies on phenol and aniline derivatives for their gas chromatographic retention values.5 Studies on discrimination of tea by Self-organizing feature map network.

本论文还利用上述方法进行了一些定量结构活性相关性研究，主要内容： 1环境中有毒有害有机物的定量结构活性相关性研究。2抗艾滋病类药物定量结构活性相关性研究。3抗肿瘤类药物(氮芥子气类化合物和2-甲酸吡啶缩氨基硫脲类化合物)定量结构活性相关性研究。4苯酚和苯胺类衍生物色谱比移值预测。5将神经网络用于茶叶的分类。

Results: The four linear calibration curves were obtained over the range 0.025μgml^(-1) to 3.2μgml^(-1) of amphetamines (amphetamine, methamphetamine, MDMA, MDA) in urine (r=0.9977-0.9998). The recoveries of the assay were better under different concentrations and the lowest concentration of detection reached the level of nanogram.

结果：4种苯丙胺类药物在尿药浓度为0.025-3.2μgml^(-1)范围内标准曲线的线性关系良好(r=0.9977-。09998)；高、中、低3种浓度各标准药物的回收率较高；日内、日间精密度的BSD基本符合小于10%的要求；最低检测浓度能够达到纳克级，具有较高的灵敏度。

U.S. Food and Drug Administration approval in addition to the use of zidovudine in addition to a block reverse transcriptase inhibitors - C, which gave birth to the first response to HIV combination drug therapy.

美国食品及药物管理局批准使用除齐多夫定之外的另一种逆转录酶阻断抑制剂--胞苷，由此诞生了第一种针对HIV的组合药物疗法。

China is now free to use the six kinds of antiviral drugs, didanosine and nevirapine, zidovudine, stavudine are domestic generic manufacturers in China protection has expired or have not applied for patent protection of drugs.

中国目前使用的6种免费抗病毒药物中，去羟肌苷、奈韦拉平、齐多夫定、司他夫定都是国内仿制在中国保护已经过期或没有申请专利保护的药物。

These results indicate that P5-2 enhanced the therapeutic efficacy of the drug against lung cancer xenografts in SCID mice.

这些结果都指出P5-2胜肽将抗癌药物送到癌组织并加强了药物杀死SCID老鼠中肺癌组织的效力。

The drugs currently used to treat this condition are heparin and warfarin, but both have drawbacks.

当前使用的治疗这种疾病的药物，是肝素和华法令，但是这两种药物都有缺陷。

A orption from solid forms : Most drugs are given orally as tablets or ca ules primarily for convenience, economy, stability, and patient acceptance.

固体剂型的吸收主要是出于方便、经济、药物稳定性、及病人接受性的考虑，大多数药物都以片剂或胶囊剂口服给药。

In the clinical triers, people with depression were treated with easier an antidepressant or a placebo , a pill that contains no medicine.

在临床试验中，抑郁病人既接受抗抑郁药物的治疗，也使用宽心剂（一种内部不含药物的药丸）治疗。

Cardiac toxicity was minimal in both groups, the editorial notes, adding that this is a major adverse effect of trastuzumab. However, the trialists point out that there was a bias, as they had selected women who had normal cardiac function after having received various other therapies (including anthracyclines and taxanes) as well as trastuzumab. Also, since the duration of observation was limited, the possibility of late events cannot be excluded."Nevertheless, the low incidence of adverse cardiac events is reassuring," they comment.

主编表示，两组之间发生心脏毒性的比例相似，且这是trastuzumab主要的副作用；然而，研究者指出其中有误差，因为他们挑选已经接受其它不同治疗（包括anthracyclines类药物与taxanes类药物）以及trastuzumab后心脏功能正常的病患；同时，因为试验观察时间长度有限，晚期发生不良反应的可能性并不能排除；他们的评论是，不管如何，心脏不良反应发生率低是可靠的。

Since historical times,England ,where the early inhabitants were Celts, has been conquered three times .

从有历史以来，英国，在此地早期居住的是凯尔特人，已经被征服了三次。

Bluetooth OBEX File Transfer Enables the sending and receiving of files on your phone via Bluetooth.

蓝牙OBEX文件移动允许经过蓝牙传送和接受文件。。。。