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Between P14 and P21,CIAPIN1 immunoreaction in the brain,heart and liverbecame much lower. However,between P21 and P28,CIAPIN1 immunoreactionin the heart,brain,liver and skeletal muscle became much lower,while with thekidney development,CIAPIN1 immunoreaction in the kidney became higher. Invarious tissues from adult mouse,CIAPIN1 immunoreaction could be seen incardiac muscle cell,brain,hepatocyte,epithelium of renal tubule,skeletal muscle,lung tissue,gastric mucosa and gland,acinus lienalis.2. Distribution of CIAPIN1 in normal fetal and adult human tissuesTo reveal the possible physiological role of CIAPIN1,we examined theexpression and distribution of CIAPIN1 in fetal and adult human tissues usingimmunohistochemistry. We found that CIAPIN1 was ubiquitously distributed infetal and adult tissues,and was localized in both the cytoplasm and the nucleus.

然而,在3个月大的成年鼠中,CIAPIN1阳性反应物在心、脑、肝和肾小管中的表达强度要低于P28小鼠;但CIAPIN1阳性反应物在成年鼠骨骼肌中较P28小鼠高。2、CIAPIN1蛋白在人5个月胚胎及成人多器官组织内的表达在人5月胚胎多器官组织中,CIAPIN1阳性反应物见于心脏、胆囊单层柱状上皮和粘膜、结肠粘膜、小肠粘膜和绒毛、肝脏、直肠腺体、胃粘膜、肾上腺束状带、甲状腺滤泡、脾索、胸腺小叶间隔、皮肤真皮层和汗腺、睾丸白膜和间质、脑组织内神经元和神经胶质、肺小支气管和肺泡、骨骼肌、肾脏皮髓质和肾小管、子宫内膜、胰腺腺泡和胰岛、卵巢、输卵管粘膜等绝大多数组织细胞。

Results (1)The permillage of myocyte apoptosis in infarct area in elder patients with sudden death caused by AMI was significantly higher than that in control group(663.00‰±117.12‰ vs 34.30‰±20.68‰,P<0 .01).However the permillage of myocyte apoptosis in 1-vessel,2-vessel,and 3 - vessel disease were 514.28±165.12‰,564.38‰±102.33‰ and 668.25‰±127. 19‰,respectiverly,significantly higher as compared to control group(All P< 0.01).But no significance was found among the three groups.(2)The size of DNA f ragment about 180~200 bp was found only in those patients with two and three ve ssels involoved.(3)The electron microscope showed the characteristics of myocyte apoptosis episodes,the others showed the characteristics of necrosis.

结果 TUNEL法发现,猝死者梗死区的心肌细胞凋亡千分数老年组(663.00‰±117.12‰)明显高于正常对照(34.30‰±20.68‰)(P<0.001);心肌细胞凋亡千分数在冠脉1支病变者(514.28‰±165.12‰)<2支病变者(564.38‰±102.12‰)<3支病变者(668.25‰±127.19‰),虽然均明显高于正常对照(均P<0.01),但三组之间比较则无统计学上的差别(均P>0.05);冠脉2~3支病变者梗死区的心肌细胞DNA电泳可见相差约180~220 bp的阶梯片段;电镜发现猝死者梗死区内的心肌细胞核膜完整、染色质浓集、电子密度增加的凋亡特征,有的则出现核膜破裂、染色质溶解成碎屑的坏死现象。

DATA SYNTHESIS: Compared with the control group, VEGF can promote osteogenesis, bone formation and remodeling through the effect of VEGF on endochondral ossification and intramembranous ossification.

资料综合:与对照组相比,VEGF能通过对软骨内成骨、膜内成骨的影响促进骨的发生、形成和改建。

Bones undergoing either intramembranous or endochondral ossification are continually remodeled from the time that initial calcification occurs until the final structure appears.

骨通过膜内骨化或软骨内骨化而不断的得以重塑,直至最后结构的形成。

Pyriformis. The half maximal inhibitory concentration (IC50) of melamine, changes of T. pyriformis cellular morphology and alterations of T.

三聚氰胺对梨形四膜虫的半数抑制浓度IC_(50,梨形四膜虫的细胞形态及细胞内蛋白质表达含量的变化是本次三聚氰胺对真核细胞毒性研究的重点。

A cancer cell in an epithelial layer is trapped unless it can force through the basement membrane, which cordons off the tissue.

除非上皮层内的癌细胞能突破基底膜-组织间的&封锁线&,否则会被束缚在上皮层内。

The results indicated that the interdigitated design of flow channel enhanced the mass transport of gases in porous media and improved the output performance of fuel cell.

模型详细考虑了电池内部的传热、传质和电化学反应,重点考察了多孔介质内的组分传递和膜内水的电渗和扩散作用,对氧气传递限制和膜内水迁移对电池性能的影响进行了分析和讨论。

For thin polycrystalline films, especially those with columnar structure, once the diameter of grains on the film surface is larger than the film thickness, the total area of above and under basal planes (film-substrate interface) will be larger than that of side plane.

对于薄膜特别是柱状晶薄膜,当晶粒在膜平面内的尺寸大于膜厚时,柱状晶粒的上底面和下底面的面积将大于侧面的面积,因此薄膜中的晶粒生长除像整体材料中的晶粒生长一样考虑晶界能外,还需要考虑表面能和界面能,因为各向异性的表面能和界面能将导致薄膜中的异常晶粒生长和织构变化。

For thin polycrystalline films, especially those with columnar structure, once the diameter of grains on the film surface is larger than the film thickness, the total area of above and under basal planes (film-substrate interface) will be larger than that of side plane. Therefore besides the minimization of boundary energy in traditional bulk material, surface energy, interface energy would be considered due to the anisotropy of surface energy, interface energy being able to drive the grain growth and texture evolution in thin films.

对于薄膜特别是柱状晶薄膜,当晶粒在膜平面内的尺寸大于膜厚时,柱状晶粒的上底面和下底面的面积将大于侧面的面积,因此薄膜中的晶粒生长除像整体材料中的晶粒生长一样考虑晶界能外,还需要考虑表面能和界面能,因为各向异性的表面能和界面能将导致薄膜中的异常晶粒生长和织构变化。

The CBFA1 knockout mice showed no osteogenesis and had maturational disturbance of chondrocytes.

CBFA1基因敲除的小鼠缺乏膜内和软骨内成骨,软骨的成熟及分化也受到了严重干扰。

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