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脑膨出

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These include anencephaly, spina bifida and cephalocele.

包括无脑畸形、脑膨出和脊柱裂。

Results There was difference in the accurance of intra-operative acute encephalocele and postoperative brain incarceration between two groups.

结果 术中急性脑膨出及术后脑嵌顿发生率在两组间比较有差异;术后中线移位、环池受压情况及术后脑积水、硬膜下积液发生率比较均无明显差异。

Results: The main reasons for acute encephalocele were delayed intracranial hematoma,acute brain swelling,hypotension or hypoxia and injury of large veins.

结果 导致脑膨出的主要原因有迟发性颅内血肿、急性弥漫性脑肿胀、低血压、低血氧及较大回流静脉的损伤。

Intraoperative acute encephalocele produce is caused by different factors.So it can be prevented and treated with corresponding measures to cut down the risk of acute brain encephalocele,and decrease the patients disability and mortality.

颅内肿瘤术中急性脑膨出由多种因素引起,针对病因采取积极适当的预防治疗措施,可以预防术中急性脑膨出的发生,减轻其发生后引起的脑组织损害,降低术后致残率和死亡率。

For example, neural tube defects (NTDs--anencephaly, spina bifida, encephalocele, myelomeningocele) usually have multifactorial causes, although they also have many specific known single-gene, chromosomal, and environmental causes.

例如神经管缺陷(NTD,包括无脑,脊柱裂,脑膨出,脊髓脊膜膨出)通常有多基因造成,虽然也有许多已知的单基因,染色体和环境原因。

For example, neural tube defects (NTDs--anencephaly, ina bifida, encephalocele, myelomeningocele) usually have multifactorial causes, although they also have many ecific known single-gene, chromosomal, and environmental causes.

例如神经管缺陷(NTD,包括无脑,脊柱裂,脑膨出,脊髓脊膜膨出)通常有多基因造成,虽然也有许多已知的单基因,染色体和环境原因。

These findings were consistent with the results of E20 cerebral cortex. iNOS was detected in E14 brain and There were no evidence changes of expression of iNOS in the encephalocoele group compared with the control group.

在Western blot分析中,发现与对照组比较,E14脑膨出组胎鼠大脑皮质中nNOS蛋白表达明显减少,eNOS蛋白表达水平明显增加,与E20结果相一致;在E14胎鼠大脑皮质中检测到iNOS蛋白微量表达,但脑膨出组与对照组比较无明显差异,E20胎鼠大脑皮质中未检测到iNOS表达。

And there were no evidence changes in histopathologic analysis of brain tissues in other ETU-injected and in control rat embryos. 2. Results of In situ cell apoptosis detection In E20 cerebral cortex, more Tunel cells were found in encephalocoele group than control group,and the results were significant.

二、应用细胞凋亡原位检测法检测不同组E20胎鼠大脑皮质中细胞凋亡情况 E20胎鼠大脑皮质中Tunel阳性细胞数目在正常组、给药无畸形组及脊柱裂组细胞凋亡数无明显改变,而在脑膨出组胎鼠大脑皮质细胞凋亡数明显多于对照组,计算凋亡细胞百分率,然后用X~2检验进行分析,脑膨出组和对照组的细胞凋亡指数差异有统计学意义(P.05)。

Expression of nNOS mRNA, eNOS mRNA and iNOS mRNA in the E 20 cerebral cortex: There were no obvious changes of expression of nNOS mRNA in ETU-injected and control groups. Expression of eNOS mRNA increased significantly in cerebral cortex of the encephalocoele group, And there were no obvious changes of expression of eNOS mRNA in cerebral cortex of the control group and the other ETU-injection groups.

六、不同组E20胎鼠大脑皮质中nNOS mRNA、eNOS mRNA和iNOS mRNA的表达 1、实时定量PCR检测发现对照组、给药无畸形组、脊柱裂组和脑膨出组E20胎鼠大脑皮质中nNOS mRNA表达无明显改变; 2、给药无畸形组、脊柱裂组和对照组胎鼠大脑皮质中eNOSmRNA表达无明显改变,而脑膨出组胎鼠大脑皮质中eNOS mRNA表达明显增多; 3、在各组未检测到iNOSmRNA表达。

Combined intra-extracranial approach, which provides excellent exposure and convenient repairing of skull base deficit is an ideal operation for meningoencephalocele.

颅鼻联合入路可提供良好视野,易找到并修复颅底缺损,便于切除颅外膨出部及一期整形,是治疗脑膜脑膨出的理想手术入路。

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