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6Exploration of the nature of denervation muscle atrophy and its counter measures.

揭示肌萎缩的本质,找到定量指标。

Results These two patients were confirmed to suffer from DMD. They were characterized by typical features of DMD including typical clinical manifestations, increased serum enzymes, EMG presenting myogenic impairment, HE staining presentation belonging to DMD, negative dystrophin in brother, and inconstantly positive on the sarcolemma of sister. Furthermore, no deletion or duplication was found in the 1-79 exons of dystrophin gene. The suffering brother and sister carried the same maternal X chromosome.

结果 兄妹二人符合DMD诊断,具有典型的DMD临床表现,肌酸激酶、肌酸激酶同工酶、乳酸脱氢酶、羟丁酸脱氢酶和谷草转氨酶的水平均显著高于正常值,肌电图呈肌源性损害,肌肉HE染色符合DMD,男患者的抗肌萎缩蛋白表达阴性,女患者的少量肌纤维仍可见不连续膜阳性,两患者抗肌萎缩蛋白基因的1~79号外显子未见缺失和重复突变,女患者与男患者携带相同的母源性X染色体。

Transcription, western, and immunohistochemical analysis showed increased levels of dystrophin transcript and protein, and correct localization at the sarcolemma.

用免疫组织化学分析用纳米作为载体进行寡聚核苷酸递送的实验鼠抗肌萎缩蛋白基因RNA和抗肌萎缩蛋白的水平得到提高,而且恢复了抗肌萎缩蛋白在肌肉细胞膜上的正确位置。

Objective To investigate the delaying effect of acupuncture on gastrocnemius atrophy after sciatic nerve injury in SD rats.

目的:研究针刺对SD大鼠坐骨神经损伤后腓肠肌萎缩的拮抗作用。

Methods: We have made out the animal model whose trigeminus nerve and facialis nerve were severed. We compared the pathologic change of facial paralysis under different nerve injury by SDS-PQGE、histiocytic chemical methods and electronic microscope.

我们分别完成了单纯面神经切断和三叉神经、面神经同时切断两组动物模型,通过组织化学、电镜以及蛋白电泳分析等方法分析了面部肌肉在上述两种不向神经损伤方式下肌萎缩的病理改变。

Aim To study the preventive and therapeutic effects of Buyang Huanwu Decoction on denervated tibial muscle atrophy of rats.

目的 研究补阳还五汤对大鼠胫前肌失神经肌萎缩的防治作用。

To study the effects of skeletal muscle satellite cell on muscle atrophy so as to provide the experimental data for treating denervated muscle atrophy.

研究肌卫星细胞对萎缩肌肉的作用,为临床提高治疗失神经肌萎缩的疗效提供实验依据。

In the research of muscular dystrophies and inclusion-body myopathies, several overseas authors have found that nitricoxide synthase and oxidative stress can induce skeletal muscle atrophy, and there is the correlation between them.

NOS的活性在CAM中是否有变化,与CAM肌萎缩的发生有无相关性, NOS引起的骨胳肌氧化-抗氧化平衡失调是否为发病机理中的重要环节,国内外均尚未见报道。

Comparing with the genetic myopathy, alcoholic myopathy is the only treatable muscle disease, and it has the certain reference value to research the other metabolic myopathy by the studying of the cytes and molecular level of CAM.

国外学者在肌营养不良症和包涵体肌病的研究中发现,一氧化氮合酶(Nitric oxide synthase,NOS)与氧化应激可诱导肌萎缩的发生,且二者具有一定的相关性。

An environment of simulated microgravity on ground was established, and its major effects on body-wall muscles of C.

这一学说是合理的,但是在细胞和分子水平导致肌萎缩的机制至今尚不完全清楚。

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