翳

The major manifestations of MR imaging included synovial hyperplasia and pannus formation, joint effusion, bone marrow oedma, adnormality of signal and shape of meniscus, soft tissue swelling, cartilage destruction,popliteal lymphagogue, et al.

结果42例JIA患者的42个膝关节可见不同程度的MR异常改变（100%），主要影像学表现包括滑膜增生及血管翳形成、关节腔渗出积液、骨髓水肿、半月板形态及信号异常改变、关节软骨破坏、腘窝淋巴结肿大等。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th／Ts及Th1／Th2平衡紊乱，抑制大鼠PHφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱，抑制大鼠PMφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

The change of the control grouph histomorphology was clear: the inerassation of synovial lining cells, the infiltration of Inflammatory cells and the erosion of nephelium of blood vessels on bones.

模型组大鼠组织形态学改变明显：关节滑膜衬里层细胞明显增犀，炎性细胞浸润，血管翳组织侵蚀骨组织等；而给药组组织形态学改变显著减轻。

The excessive expression of VEGF is one of the main causes of synovium hyperplasia and pannus formation.

血管内皮生长因子过度表达是滑膜增生、血管翳形成的主要原因之一，它的表达与关节受累范围及病变程度密切相关，针对VEGF的治疗已取得一定疗效。

In this paper,we provided a review in following aspects:the synovial angiogenesis process,influencing factors,and treatment of RA targeted on pannus and synovial angiogenesis,with the view to provide ideas and reference for the treatment of RA.

本文从滑膜血管生成过程及其影响因素以及以滑膜血管或血管翳为靶标的RA治疗策略3个方面进行了初步的阐述，以期为RA临床的防治研究提供思路和参考。

The expression of VEGF is relative to the synovial pannus formation in the rheumatoid arthritis.

痹肿消汤可能通过阻断VEGF的表达来阻抑关节炎滑膜血管翳的形成或骨质侵袭。

Results MRI results showed that synovial hyperplasia and enhanced pannus in the wrists could be seen in all the cases, while hone marrow edema, hone erosion and joint effusion could be seen in 65, 50 and 54 cases respectively.

结果78例早期RA的MKI征象：滑膜增厚78例，血管翳强化78例，骨髓水肿65例，骨侵蚀50例，关节积液54例，腱鞘炎3例。

The reason of the disease is uncertain and its pathologic change is chronic Inflammation of joints, cell infiltration, information of pannus and the erosion of cartilage and bones, which lead to the destruction and dysfunction of joints structure.

本病病因未明，主要病理变化为关节滑膜的慢性炎症细胞浸润、血管翳形成、软骨及骨组织的侵蚀，导致关节结构的破坏和功能丧失。

It has great value to diagnose RA when pannus enhancement in MRI existed simultaneity with morning stiffness or and RF positive.

结论MRI血管翳强化与晨僵或类风湿因子阳性同时存在时，对于诊断早期类风湿关节炎具有较大的价值。

Since historical times,England ,where the early inhabitants were Celts, has been conquered three times .

从有历史以来，英国，在此地早期居住的是凯尔特人，已经被征服了三次。

Bluetooth OBEX File Transfer Enables the sending and receiving of files on your phone via Bluetooth.

蓝牙OBEX文件移动允许经过蓝牙传送和接受文件。。。。