结合性的

Truncation mutations in the adenomatous polyposis coli protein are responsible for familial and sporadic colonic tumours. Except for its function as a role in regulating b-catenin, recent studies show that APC has additional roles in cytoskeletal regulation. It binds to microactin and microtubules directly and indirectly. Furthermore, APC plays an important role in mediating the detraction of chromosome.

编码APC蛋白(adenomatous polyposis coli， APC)基因的缺失突变会导致家族性和散发性的结肠癌，APC蛋白除了能直接参与Wnt信号途径调节b-catenin的浓度之外，最近的研究表明APC蛋白能够与细胞骨架的主要成分微管和微丝直接或间接结合，通过调节微管的解聚和聚合，间接调节染色体的分离，作为潜在的细胞骨架调节分子将细胞骨架与重要的细胞信号转导通路紧密联系在一起。

The dissertation focuses on performance gradient estimation and SRO algorithm of DES aswell as other related topics,such as modeling of DES and discrete event simulation,performancemeasure Hessian matrix estimation,Stochastic Approximationand so on.General Semi-Markov Processis adapted to describe behaviour of DES and discrete eventsimulation.A general result is obtained and applied to analyze strong consistency of performancegradient Perturbation Analysisestimator.Conditions for effectiveness of InfinitesimalPerturbation Analysisare also discussed.New PA algorithms,such as server PA,PA usingDirac generalized function,job sequence PA etc.,are proposed to deal with discreteparameters.Furthermore,strategies of combining PA algorithms with certain iterative rules areanalyzed widely in order to optimize DES parameters and some SRO algorithms are constructed toslove DES optimization problems.

论文将DES性能分析领域中性能梯度估计和单运行仿真优化作为主要的研究对象，探讨了与性能梯度估计有关的DES和离散事件仿真过程建模、高阶导数估计以及随机逼近等理论和方法；建立了具有一般性的DES和离散事件仿真的广义半Markov过程模型；获得了分析性能梯度估计量强相合性的理论结果和无穷小摄动分析算法应用的条件；提出了诸如服务台数目的摄动分析、奇异摄动分析、串联生产线和加工车间中工件加工序的摄动分析等一系列摄动的思想和算法，对连续参数和离散参数都进行了深入的研究；对摄动分析算法同优化规则结合实现仿真优化的策略也进行了广泛的分析，构造了新型的变界截尾的随机逼近算法，并用于DES的单运行仿真优化研究；最后，给出了DES性能分析方法的实证性研究结果。

In accordance with the technological difficulties encountered in the process of insulation supervision based on the Dissolved Gases Analysis,several kinds of model and method are presented to improve the reliability and precision of fault diagnosis of the power transformer. Main research content includes:By deeply studying the common transformer faults diagnosing methods,such as three-ratio methods and improved electrical committee agreements,several shortcomings such as uncertainness judgment when the fault reasons,phenomenon and principles come out together while can not consistent to each other etc. For this reason,the old methods can not fully meet the need to engineering practical application.Considering fuzzy relationship matrix can fully represents the causality between fault symptoms and fault types,when diagnosing complex equipments with multiple symptoms and fault causes such as power transformer,a synthetic fuzzy diagnosing model is firstly proposed to diagnose transformers insulation faults based on DGA in this paper. Meanwhile,by further study the character of fuzzy factors,aimed at correcting the defects in classifying fuzzy sets of common fuzzy judgment,a method are put forward by unifying fuzzy synthetic diagnosis and fuzzy principle reasoning.

本文针对应用油中溶解气体分析方法进行变压器绝缘监督时所遇到的主要技术难点，提出了提高变压器故障诊断的准确性、可靠性的几种模诊断方法，主要研究内容有：通过对判断变压器故障常用的三比值法和改良电协研法的深入分析，其诊断准确率较高，但对故障原因、故障现象和故障机理间同时存在不确定性和模糊性的变压器等电气设备的故障诊断，难于满足工程应用的需要；在处理变压器等结构复杂设备的多症状、多原因故障诊断时，模糊关系矩阵可以全面反映这种症状与故障类型间的因果关系，进而提出了变压器故障诊断的模糊综合诊断模型；同时作者还深入分析了模糊算子的特性；针对常用的模糊评判结果的模糊集的集化方法的不足性，提出了将模糊综合诊断与模糊规则推理结合起来进行故障诊断的方法，能达到较好的效果。

As a result, it is essential to seek a viable and integrated judgement model to promote administrative procedures legitimacy,which combine the characteristics of the administrative procedures and commentation of the tradition judgement model.

笔者通过对程序正当性的传统判断模式的述评，结合行政程序自身的特点，提出构建行政程序正当性的整合判断模式，以期寻求一种较为可行的判断模式。

Urban Remnant Natural Area is left behind in the urban planning area along with urbanization. Its landscape assessment is significant for urban natural preservation. On the basis of URNA's characteristics and in line of the domestic actual situation, psychophysical method, one of the most scientific and credible methods, is chosen to establish the complete landscape assessment system, including acquiring scenic beauty value by SBE method, dividing into different influencing factors by SD method, and setting up their connection model by multiple linear regression analysis. This method is also revised during the application process.

城市自然遗留地是随着城市化的进程在城市规划区内遗留下来的用地，根据城市自然遗留地城市性、自然性和遗留性的特点，结合国内的实际情况，运用目前最严格、可靠性最好的心理物理学方法，以相片为测试材料，采用SBE法获得美景度量值，SD法测定各景观要素量值，以及多元线性回归方法建立2者的关系模型，最终提出了城市自然遗留地景观美学评价完整的方法体系，并修正和完善了心理物理学方法在城市自然遗留地领域的具体应用。

The synthetic study that makes theory into practice is little. And the dissertation of the strategy that base on the core capability is little too. By studying the characteristic of dynamic situation and core capability, the text formulizes the relationship between core capability and the strategy of the enterprises. By means of SWOT, the text takes the important position of time and core capability into account and tries to analyze core capability-based strategy. The text emphasizes the balance between the foundation of core capability and the exertion of core capability in order to acquire the dominance of competitive advantage. By means of PDCA, on the base of the dynamic characteristic of core capability and the strategy, the text integrates the core capability and the strategy together. On the base of the core capability, the text analyzes the strategy of low cost, difference, merger and diversification, and gets the goal and measurement of these kinds of strategy. Through the study of these issues, the text integrates the core capability and strategy, and.

文章从核心能力的特征入手，分析企业所面临的动态环境以及由此而产生的核心能力的动态性的特点，并阐述了核心能力动态性与企业战略之间的关系；本文运用SWOT方法，首次通过对时间因素与核心能、力的重要地位的融合，在基于核心能力的企业战略的分析方法方面进行了尝试性的论述；本文强调对企业的核心能力的构建与其运用进行合理的平衡，以保证企业资源的合理分配及更好的获得企业竞争优势：运用PDCA分析方法，在综合了核心能力与基于核心能力的战略的基础上，将两者综合起来进行动态的分析，力图实现核心能力与战略的更好的结合；另外，本文对传统的低成本与差异化战略进行基于核心能力基础上的分析，大胆提出了通过对核心能力及其要素分解的判断，进行低成本、差异化战略进行选取的方法，并将此方法与传统的低成本、差异化战略的决策模式进行优势比较；也通过与核心能力的结合，对企业购并和多元化战略进行新的角度的分析，得出了基于核心能力的企业购并与多元化战略的分析、制定方法以及实施的注意事项。

In the basis of comparing the developing projects on the optical interconnection networks, combining with the actual probability of realization, we proposed the scheme of free space optical crossbar interconnection network using spatial light modulator . This interconnect structure is the most powerful single level interconnect network with the characteristics of reconfiguration and non-blocking. It can achieve arbitrary point-to-point link. Even more has it the ability of broadcasting and funnelling.

在比较现有的光互连方案的基础上，结合具体的可实现性，本文提出了使用空间光调制器的自由空间光学交叉开关互连网络的方案，这种互连结构是功能最强的单级互连网络，具有可重构性和非阻塞性，不仅能实现任意点到点的连接，还具有广播和汇集的能力。

Summary: Company's equity valuation is a new and developing research field of accounting. it is a field in which more than one branch of knowledge overlap. In the west, scholars and practiser pay more attention to it.this paper discusses interrelated hypothesis ,rudimental form and all kinds of transfiguration of residual income valuation modelthat be extensivly applied in the related documents , and then we do an empirical research based on RIM on chinese corporation.

公司权益估价作为一个多学科交叉的会计学新兴研究领域，在西方得到了众多的理论研究者与实务工作者的关注，本文对近年来在一些国外著名会计文献中频繁出现的剩余收益估价模型的相关假设、一般形式进行了框架性的理论论述，并依据此理论框架结合中国证券市场对会计信息的决策有用性进行了实证研究。

Sexual Secrets is the only television series that combines equal measures of fun, down-to-earth talk, and need-to-know information to present a highly entertaining look at that most primordial of human urges sex.

性的秘密是唯一的电视连续剧，结合乐趣，坦诚的谈话，你能知道那么多信息，呈现出非常引人入胜的那个最原始人类的冲动--性。

The quantitative and qualitative methodologies were both used in this thesis, andby presently observing of English Immersion classroom teaching and video taperecording, a lot of information about teacher-child speech interaction was collected. Theinternational Child Language Data Exchange System, known as CHILDES, wasadopted to analyze the collected information qualitatively and quantitatively.

本项研究采用量化研究和质性研究相结合的方法，通过对幼儿园大、中、小班英语浸入式教学活动的现场观察和录像收集师幼言语互动语料，运用国际通用的儿童语言数据交流系统——CHILDES，对收集到的师幼互动交流言语数据进行统计分析，在对研究资料进行量化分析的同时，对研究结果进行质性的分析和讨论，并提出了相应的教学建议。

What are your goals and strategies for growth?

你的成长目标和策略是什么？

And unto the angel of the church in Sardis write; These things saith he that hath the seven irits of God, and the seven star I know thy works, that thou hast a name that thou livest, and art dead.

3：1 你要写信给撒狄教会的使者，说，那有神的七灵和七星的，说，我知道你的行为，按名你是活的，其实是死的。