粘附

Objective:To investigate the effect of berberine on lymphocyte-endothelium adhesion and cell adhesion molecules.

摘 要 目的：通过研究小檗碱对淋巴细胞与血管内皮细胞粘附及粘附分子的影响，探讨小檗碱免疫抑制作用机制。

METHODS: Autologous whole blood was injected into the vitreous cavity of albino rabbits after canalization, thus induced experimental PVR model. Concentration of PDGF.

采用眼穿通伤+注血法制备PVR模型，进行眼底及常规组织病理学观察，ELISA法检测玻璃体中血小板源性生长因子的浓度，用免疫组织化学方法观察增生膜与血管内皮细胞表面血管细胞粘附分子-1（VCAM-1）及细胞间粘附分子-1（ICAM-1）的表达。

The turbulence of granulocytes CD11b, CD62L expression were found not only during hemodialysis but also before a single hemodialysis course. All of these changes are not associated with the dialyzer membranes.

血液透析对中性粒细胞粘附分子的表达有规律性的影响，这可能损害了中性粒细胞的粘附能力，削弱了机体的免疫力。

Neural cell adhesion molecule L1, discovered in the 80s, is one of the matters that can promote nerve regeneration. It can mediate the interaction of cell-to-cell and cell-to-matrix, take great efforts on neurite outgrowth and fasciculation, migration of neural cells, formation of the myelin, structure of neural trace, transmembrane signal transduction, inhibiting apoptosis of neural cells, even on immune system and formation of the tumor. Li is discovered on the mouse's Cerebellar membrane primarily. Thereafter, it also is found in post- mitotic neurons, pre- and non-myelinating Schwann cells and so on.

神经细胞粘附分子L1（L1）是80年代发现的具有促进神经再生作用的物质，它能介导神经细胞与神经细胞之间的粘附，在神经轴突的生长、聚集，神经细胞的转移，纤维髓鞘的形成，神经通路的构建及信号的转导，抑制神经细胞的凋亡甚至在免疫系统、肿瘤的发生等方面均具有非常重要的作用。L1最初是从小鼠的小脑膜中发现，后来发现在有丝分裂后的神经元，髓鞘形成前及非形成髓鞘的雪旺细胞等组织中同样存在。

Summary: In this study, the change of adhensive struture, adhensive moleculd and actin filament in K-ras gene transfected pulmornary fibrocyte of mice, and the mechanism of invasion and metastasis of cancer cell were investigated by molecular biological techniques.

小结：本研究利用分子生物学技术，探讨K-ras基因导入的鼠肺纤维细胞—恶性转化细胞的粘附结构、粘附分子和肌动蛋白的改变，旨在探讨肿瘤细胞的浸润转移机制。

Objective To determine the expression of CD44 in the liver tissue.Method 26 cases of liver cancer,16 cases of hepatocirrhosis and 5 cases of normal liver tissue were studied by HE stain and immunohistochemistry.

CD44是一种粘附分子，能介导细胞与细胞以及细胞与基质间的粘附，近年来的研究发现它与人体肿瘤的发生、发展及转移有着密切的关系，对肿瘤病人的预后判断具有重要的意义。

ObjectivesThe aim of this study was to assess the influence of holothurian glycosaminoglycan on the adherence of thrombin-induced platelets to human umbilical vein endothelial cells in a flow chamber system.

海参糖胺聚糖抑制血小板—内皮细胞粘附及其机制的研究目的血小板-内皮细胞粘附在血栓形成，尤其在动脉血栓形成中占有举足轻重的地位。

Study on effects of differentiation inducer on adhesion, movement and invasion of chordoma cell line in vitro

结果： 分化诱导剂HMBA诱导的CM319细胞在30 min和90 min粘附实验中的粘附率，分别下降了27%和31%。

METHODS AND RESULTS: Adherent platelets express substantial amounts of SDF-1 and recruit CD34+ cells in vitro and in vivo. A monoclonal antibody to SDF-1 or to its counterreceptor, CXCR4, inhibits stem cell adhesion on adherent platelets under high arterial shear in vitro and after carotid ligation in mice, as determined by intravital fluorescence microscopy.

方法和结果：在体和离体的粘附血小板表达大量SDF-1、募集CD34+细胞，在体荧光镜下可见，在小鼠颈动脉结扎后、离体条件下的动脉内高剪切应力时，SDF-1或其相应受体的单克隆抗体－CXCR4抑制干细胞粘附于血小板上。

First, we made a model of exhaustive exercise in rats, and used sucessfully the model in this study. We studied the effects of exhaustive exercise on adhesive behaviour of leukocytes in mesenteric venules by using an intravital microscope video system Its results indicated that the adhesiveness of circulating leukocytes to mesenteric venules enhanced after exhaustive exercise in rats.

首先，本文以游泳方法建立了大鼠模拟运动力竭模型，并成功地将此模型运用到本研究中；设计制作了肠系膜固定有机玻璃板，组成了一套活体显微观察实验系统；研究了大鼠运动力竭前后肠系膜微循环中白细胞粘附行为，结果表明：大鼠运动力竭后肠系膜微循环血流流态发生了明显的改变，大鼠运动力竭后肠系膜微循环中白细胞粘附性增强、白细胞滚动速率降低、在体白细胞变形性减小，将影响微循环正常的灌注，是导致微循环障碍发生发展的一个重要原因，进而最终表现为机体运动能力和运动质量下降。

Objective: To study the effect of polycythemia on blood oxygen saturation.

裴蕾目的：观察RBC剧增而引起的高粘血症对血氧饱和度的影响。

Based on SIMPLER algorithm in the curvilinear body-fitted coordinates, the calculations were performed for Pr=0.7, Re=10~1000 on non-orthogonal non-staggered grids which are generated by elliptic equation systems.

采用曲线坐标系下压力与速度耦合的SIMPLER算法，数值研究了周期性渐扩渐缩波纹通道内脉动流动与换热情况，流动Re数的范围为10~1000，Pr数为0.7。