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等位基因

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The allele frequency of ALDH2*1 between alcoholic cardiomyopathy group and alcohol dependent group was significantly higher than that in controls and the allele frequency of ALDH2*2 between alcoholic cardiomyopathy group and alcohol dependent group was significantly lower than that in controls.

嗜酒组和酒精性心肌病组ALDH2*1等位基因的频率高於对照(P.01),ALDH2*2等位基因的频率低於对照组(P.01)。

The most common allele was allele 5 with a frequency of 70.6%.

最常见的等位基因是5等位基因(DRD4*5),频率为70.6%。

Mapping of microsatellite markers in two wheat crosses segregating for Pm23 and Pm4b, respectively, in combination with the reported mapping of Pm4a, indicated that the three genes were all linked to the marker Xgwm356 with a distance of 3-5 cM. Allelism between Pm4b and Pm23 was then confirmed, when the progenies of a cross between VPM1 (Pm4b) and Line 81-7241, were shown to be all resistant to a B.

利用获得的8个标记对Pm4b进行遗传作图,结果表明,4个标记与Pm4b连锁(Xgwm356、Xgdm93、Xbar76和Xbarc122)。3个抗白粉病基因(Pm4a、Pm4b和Pm23)均与标记Xgwm356连锁,遗传距离为3-5cM,等位性测验证明Pm23与Pm4b为等位基因

Gene mutations were detected in 25 patients and a 18-year-old girl among 16 families. Trinucleotide repeats of CAG were 73~79. The fragments of abnormal alleles were 380~402bp, and all patients were heterozygous. The copy numbers of normal alleles were 18~40, fragments from 202~270bp. SCV reduction was much obvious compared to MCV, MCV and SCV in lower limb ?ere much more slow than that in upper's. BAEP, VEP were also delayed in latency. The anticipation in parental sex bias were much more obvioius than that in matental's. Cerebellar ataxia was most severe, the next were dysarthria and bulging eyes. Amytrophy was seen only in bed ridden patients. Cerebellar atrophy was more severe than brain stem, cord atrophy was n't observed in all MJD.

结果检出10个家系25例病人及1例症状前18岁女孩有MJD基因突变,CAG三核苷酸重复73~79次,异常等位基因片段长380~402bp,均为杂合子;正常人CAG三核苷酸重复18~40次,等位片段长200~270bp,电生理发现MJD的SCV减慢比MCV明显,而下肢的MCV、SCV又较上肢明显,BAEP、VEP均有不同程度的潜伏期延长或波的异常;MJD的父亲遗传早于母亲,进展也较块,临床以小脑性共济失调为突出症状,其次为构音障碍、突眼等,肌肉萎缩仅见于晚期病人;MRI示小脑萎缩较明显,脑干萎缩并不严重,未见明显的颈髓萎缩。

These were controlled by multiple allels or by loci with allels that segregate independently whereby epistasis also may have played a role.

这些是受复等位基因或含分离等位基因的位点支配的,上位性也可能靠它而起了作用。

Genetic polymorphism and effect of MC4R gene(1) The distribution of genotype is significantly different among 6 breeds.

在外来品种中有更多的等位基因G,在地方品种中有更多的等位基因A。

It was found that the polymorphism existed not only at the allele level but also at the locus level;many alleles of the microsatellite loci and some of the microsatellite loci had been lost during the process of artificial gynogenesis.

该实验结果还发现不仅草鱼的微卫星位点上存在等位基因的多态性,而且微卫星位点本身也存在多态性;在人工诱导草鱼雌核发育的过程中不仅存在微卫星等位基因快速丢失的现象,而且也存在微卫星位点丢失的现象。

A new RHAG mutation was found firstly in Chinese population,it is a 582 C>T homozygosity mutation in RHAG gene.

首次在中国人群RhD变异型标本中发现一例新的RHAG等位基因,该等位基因是RHAG外显子第582位C>T杂合突变。

There were totally 22 alleles of these microsatellite loci, and the number of alleles per locus ranged from 2 to 6. The average homozygosity, average polymorphism information content and average heterozygosity was 41.67%, 0.488 and 0.5833, respectively.

对这6个位点的扩增产物进行分析,结果显示:6个位点共检测到22个等位基因,每个位点的等位基因数从2个到6个不等;平均基因纯合率为41.67%,平均多态信息含量为0.488,平均杂合度为0.5833。

The main clime features included ataxia, hypopsia, axanthocyanopsia and retinal pigmental degeneration. Alleles from 7 to 9 repeats were seen in the other 4 healthy members. GAG repeats from 6 to 21 were found in other 126 SCA patients, 71 family members and 60 healthy controls.

该家系内表型正常的4位成员SCA7等位基因CAG重复数目为7~9,另126例临床表现为SCA的患者、71名表型正常的家系成员及60名健康对照者SCA7等位基因内CAG三核苷酸重复数为6~21。

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