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In ACC, NGF,TrkA and p75 mainly existed in cells of duct-like, cribriform and mass-like structures.According to the optical density scanning of immunohistochemistric stain of NGF and TrkA in salivary gland and tumor tissues and quantification analysis, it was shown that the average optical density of NGF and TrkA increased in order of salivary gland tissues around neoplasm, mucoepidermiod carcinoma, and adenoid cystic carcinoma.

2叫 吉林大学硕士学位论文通过对NGF和TrkA在涎腺组织和涎腺肿瘤中的免疫组织化学染色结果进行光密度扫描,对所测平均光密度定量分析,结果显示:NGF和TrkA平均光密度值按照肿瘤周围涎腺组织、豁液表皮样和腺样囊性依次升高,统计学分析在各组间均有极显著差异(P.01),表明NGF和TrkA通过自分泌机制调控涎腺腺样囊性和豁液表皮样的生长与增殖,通过旁分泌机制参与涎腺腺样囊性向神经周围的浸润。

objective:our aim is to investigate the relationship of vegf c,vegf d and lymph node metastasis in pancreatic cancer,and to elucidate the role and significance of the cancerous peripheral lymphatic tissue.methods: the expression of vegf c and vegf d was assayed by means of immunohistochemistry in 30 pancreatic carcinomas.results:the positive rates of vegf c、vegf d were 73%(22/30)、57%(17/30) respectively in pancreatic cancer.the expression of vegf c、 vegf d in cancerous invasive edge was significantly higher than that in the center of cancerous tissues.there was no correlation between the expression of vegf c、vegf dand the site,differentiation,histology types.

目的:探讨胰腺中vegf c、vegf d蛋白表达与淋巴结转移之间的相关关系,阐明周淋巴管增生在胰腺淋巴转移中的作用及意义。方法:免疫组化检测30例胰腺组织中vegf c、vegf d的表达及其与临床病理、淋巴结转移的关系。结果:胰腺vegf c、vegf d蛋白表达阳性率分别为73%(22/30)、57%(17/30),肿瘤周边部位显著高于肿瘤中心部位,其表达与肿瘤的部位、分化程度、组织学类型无关,与肿瘤的tnm分期有关,ⅲ~ⅳ期显著高于ⅰ~ⅱ期。

Ductal carcinoma in situ is the intermediate stage between precancerous lesions and invasive breast carcinoma, surgery, radiotherapy and risk reduction endocrinotherapy have become the main treatment for DCIS.

导管原位是乳腺的早期阶段,但是,纯粹的导管原位不具有侵袭性,被看作前病变和的中间状态。手术切除、放疗加降低风险的内分泌治疗是导管原位主要治疗方法。

The cells at the edge of the basaloid islands tended to show palisading arrangement. Squamous epithelium on the surface of tumor often accompanied with carcinoma in situ or superficial invasive squamous cell carcinoma. Occasionally cancer nets were connected with basement layer of squamous epithelium laying in the surface, and rare squamous cells or glandlike structures were seen in the cancer nests.

但BSC细胞分化较低异型性较强,巢周围细胞呈栅栏状排列,肿瘤表面鳞状上皮常伴发原位或浅表浸润性鳞状细胞;偶见巢与表面鳞状上皮基底层相连、或偶见巢内形成鳞状细胞,或腺管样结构,这些与ACC不同。

Methods Thirty-two cases with positive incisal margin in gastrectomy for gastric carcinoma from 1988-1993 in this hospital were retrospectively studied.

对我院1988年1月至1993年4月胃切除术切端残留32例进行回顾性分析。结果胃切除术切端残留率为7.5%(32/428),其中近端残留11例,远端残留17例,近远端均有残留4例。

Methods: the expression of s100a4 protein was detected in 130 cases of thyroid tissue by immunohistochemistry. there were 55 cases of papillary thyroid carcinoma and 30 cases of matched samples of adjacent normal thyroid tissue, 15 cases of follicular thyroid carcinoma, 10 case of medullar thyroid carcinoma, 50 cases of benign thyroid neoplasm(25 cases of simple benign multimodal goiters and 25 cases of follicular adenoma), 5 cases of normal thyroid tissue.

用免疫组化检测130份甲状腺石蜡标本的s100a4蛋白表达情况,其中甲状腺80份(乳头状55例、滤泡15例、髓样10例);甲状腺良性肿瘤50份(结节性甲状腺肿、甲状腺滤泡型腺瘤各25例);旁甲状腺组织30例;正常甲状腺组织5例。

Results Although overexpression of P53 protein was not detected in normal eyelid cutaneous epithelium, meibomian gland and mild epithelial dysplasia, the positive rate of P53 increased in degree in moderate and severe dysplasia, carcinoma in situ and invasive tumors, and PCNA labeling index progressively increased too. Overexpression of P53 protein was detected in 30/53 cases of basal cell carcinoma, 16/32 cases of squamous cell carcinoma, 10/17 cases of meibomian gland carcinoma, and the intensity of P53 protein immunostaining increased with the lowering in the degree of histological differentiation.

结果 在正常眼睑皮肤、睑板腺及轻度不典型增生眼睑上皮中,未见P53蛋白表达,而中、重度不典型增生,原位,浸润中,P53蛋白阳性表达率逐渐增高,其 PCNA指数也有增加趋势。30/53例基底细胞(basal cell carcinoma,BCC)、16/32例鳞状细胞(squamous cell carcinoma,SCC)、10/17例睑板腺中,P53蛋白阳性表达;同时,随着肿瘤组织分化程度的降低,P53蛋白阳性表达程度有逐渐增高的趋势。

Results Although overexpression of P53 protein was not detected in normal eyelid cutaneous epithelium, meibomian gland and mild epithelial dysplasia, the positive rate of P53 increased in degree in moderate and severe dysplasia, carcinoma in situ and invasive tumors, and PCNA labeling index progressively increased too.

结果 在正常眼睑皮肤、睑板腺及轻度不典型增生眼睑上皮中,未见 P53蛋白表达,而中、重度不典型增生,原位,浸润中, P53蛋白阳性表达率逐渐增高,其 PCNA指数也有增加趋势。30/53例基底细胞(basal cell carcinoma,BCC)、16/32例鳞状细胞(squamous cell carcinoma,SCC)、10/17例睑板腺中, P53蛋白阳性表达;同时,随着肿瘤组织分化程度的降低, P53蛋白阳性表达程度有逐渐增高的趋势。

In fact most cases of metaplastic carnoma belong to the spectrum of basal-like carcinomas based on the definition, such as spindle cell ca, squamous cell ca, adenosqumous.

实际上,按照定义大多数化生性属于基底细胞样的范围,如:梭性细胞、鳞状细胞和腺鳞

Results: Among 46 lesions there were 30 squamous cell carcinomas (65.2%), 8 adenocarcinomas(17.4%), 4 large cell carcinomas(8.7%), 3 small cell carcinomas(6.5%), and 1 mixe...

结果46例中,鳞30例(65.2%)、腺8例(17.4%)、大细胞4例(8.7%)、小细胞3例(6.5%)和混合性1例(2.2%)。

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