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No entire nitrendipine crystals were observed visually in SEM photos. The results of X-ray diffraction and differential scanning calorimetry analysis indicated that the crystalline form of nitrendipine was highly dispersed in microspheres, so as amorphous state. The drug release rate of microspheres could be controlled with adjusting the ratio of solid dispersion carriers and retarding agents formulated. The agitation speed and temperature of the preparation process have distinct effect on micromeritic properties of microspheres. The release profiles of the microspheres were mainly affected by the stirring rate of paddle, the concentration of SDS and pH of dissolution medium. Cooling speed and time, however, have no evident influence on the drug release rate of the microspheres. The dissolution data showed that the mechanism of drug release from microsphers was mainly diffusion-controlled. The incorporation efficiencies of 3 batches sample were exceed 96. 8%, which implied that the current method was suitable for design sustained-release dosage form for poorly water-soluble drug.

在扫描电子显微镜下观察,在微球内外未发现尼群地平的完整结晶,X-射线粉末衍射和差示扫描量热试验结果也显示,尼群地平已经被高度分散在微球中;微球的释药速度可通过调整处方中固体分散体载体和阻滞剂的比例控制;制备温度和搅拌速度对微球的质量影响较大;溶出仪的搅拌速度,释放介质的浓度和pH对微球的释放有较大的影响;制备过程中的冷却速度和冷却时间对微球的释放行为影响不很明显;方程拟合的结果表明缓释微球的释药行为符合扩散机制;测定三批微球样品的包封率均在96.8%以上,表明该法适合于制备难溶性药物的缓释微球。

The plasma ignition threshold of metal is got through experimental and numerical study. The vapour and plasma ignition times of the target are got based on the equation of heat conduction and cascade model. We suppose that the plasma is ignited when generations of new electrons are born in vapour generation time. The influence of temperature on the thermodynamics and optics parameters of material also have been considered in the model. The resulting theory has good agreement with the experiment and overseas report. A blade method to measure the laser spot is given in this paper with validation and error analysis. The plasma threshold of metals in atmosphere and water ambients both are diagnosed with the light deflection and piezoelectric transducer. A Q-switched pulsed Nd:YAG laser operating at infrared (1064nm), visible(532nm) and ultraviolet (355nm) wavelengths has been used. Al、Fe、Cu are used as targets and get a similar results with both method. Theoretical and experimental analyses are applied on the influence of wavelength on the threshold have been done, both of which have shown that the plasma threshold of metals decrease as the laser wavelength increases; The plasma threshold of metals are higher in water than in air and the pressure of the shock wave in water is five times higher than in air .

从热传导方程和雪崩电离机制出发,假设当电子增值210倍时,考虑了温度对材料热力学和光学参数的影响时,得到了气化和等离子体点燃的时间,利用该模型进行计算得到的结果与国内外报道及自行通过实验测得的阈值基本一致;提出了利用刀刃法测量激光光斑面积的方法,并通过实验进行了验证和误差分析;利用光偏转装置和压电换能器分别对空气和水中金属等离子体点燃阈值进行了实验诊断,激光器均为调Q-YAG激光器(波长1064nm,532nm,355nm,脉宽10ns),靶材分别为Al、Fe和Cu,两种测试方法得到的等离子体点燃阈值基本一致;本文从实验和理论计算两个方面讨论了波长对等离子体点燃阈值的影响,均得到了等离子体点燃阈值随著波长的增加而减小的结论;对空气中和水中不同环境下金属等离子体的点燃阈值进行了比较研究,得到了金属在水中的等离子体点燃阈值比空气中的大,且水中产生的冲击波的压强是空气中的5倍左右的结论。

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What are your goals and strategies for growth?

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And unto the angel of the church in Sardis write; These things saith he that hath the seven irits of God, and the seven star I know thy works, that thou hast a name that thou livest, and art dead.

3:1 你要写信给撒狄教会的使者,说,那有神的七灵和七星的,说,我知道你的行为,按名你是活的,其实是死的。

"It is a testament to making sure unemployment compensation is available, making sure we are looking out for people who have lost their jobs," she said.

"这是个实证,证明我们必须确保人们都可以得到失业补偿,确保那些失去工作的人们得到照顾。"