热性痛觉

RESULTS: The capsaicin receptor TRPV1 is a polymodal nociceptor exhibiting a dynamic threshold of activation that could be lowered under inflammatory conditions.

结果：辣椒素受体TRPV1是一种多模式伤害性感受器，具有可在炎性情况下降低的动态激活阈值，与此模式一致的是TRPV1敲除的小鼠缺乏炎症后热性痛觉过敏。

The latedischarges decreased from 9.29 ± 0.97 to 6.71 ± 0.68 with the A-fiberconditioning stimulus increasing from 1 to 5 (n〓8, P〓0. 05).(7) The intervalbetween the conditioning stimulus and test stimulus (C-T interval) wasincreasing, the inhibition tended to plateau off. At shorter time intervalsthe inhibition became more effective. When C-T interval was limited in 50ms,the inhibitory effects was the strongest, here, the late discharges reducedfrom 12.57±1.21to 2.29±0.42 (n=11, P＜0. 01).(8) Behavior research showedthat the rat model of snake venom exhibited neuropathic pain with heathyperalgesia, cold and mechanical allodynia, which corresponding to the acuteelectrophysiological findings.

此时轻刷WDR神经元的感受野不能引起其活动改变，但伤害性齿镊夹捏仍可引起WDR神经元放电增多；〓5〓晚成分放电的潜伏期缩短，即宁静期的时程变短，由给蛇毒前的118.83〓3.67ms降至50.72〓1.36ms〓n〓32，P〓0.01〓；〓6〓在正常动物，如果预先给予只激活A纤维的弱条件电刺激〓mA，100μs〓可抑制随后的伤害性检验刺激所诱发的WDR神经元的晚成分放电，当条件刺激个数从1增加至5时，每次伤害性检验刺激所诱发的晚成分放电数从9.29〓0.97个降至6.71〓0.68个〓n〓8，P〓0.05〓；〓7〓固定条件刺激数为1个，当条件刺激与检验刺激之间的间隔增大时，A纤维条件刺激对WDR神经元晚成分放电的抑制作用逐渐减弱，当条件刺激与检验刺激之间的间隔在50 ms以内时，抑制效应最为显著，此时，晚成分放电数由正常时的12.57〓1.21个降至2.29〓0.42个〓n〓11，P〓0.01〓；〓8〓与急性研究中的WDR神经元电活动的变化结果相匹配，利用蛇毒制备的大鼠模型在行为学上表现为热痛觉过敏、冷觉的痛性感觉异常及机械痛觉过敏等慢性痛症状。

At the same time, most WDR neurons failedto respond to the light brush applied to the receptive fields, but they couldbe intensively excited by the noxious pinch.(5) The latency of the latedischarges was shortened from 118.83 ± 3.67ms to 50.72 ± 1.36ms (n〓32, P〓0. 01).(6) Preceding graded number of A〓fiber conditioning inputs (〓mA, 100 μs) delayed the C-activity evoked by the following nociceptive teststimulus activating both A- and C-fiber applied to the sciatic nerve. The latedischarges decreased from 9.29 ± 0.97 to 6.71 ± 0.68 with the A-fiberconditioning stimulus increasing from 1 to 5 (n〓8, P〓0. 05).(7) The intervalbetween the conditioning stimulus and test stimulus (C-T interval) wasincreasing, the inhibition tended to plateau off. At shorter time intervalsthe inhibition became more effective. When C-T interval was limited in 50ms,the inhibitory effects was the strongest, here, the late discharges reducedfrom 12.57±1.21to 2.29±0.42 (n=11, P＜0. 01).(8) Behavior research showedthat the rat model of snake venom exhibited neuropathic pain with heathyperalgesia, cold and mechanical allodynia, which corresponding to the acuteelectrophysiological findings.

此时轻刷WDR神经元的感受野不能引起其活动改变，但伤害性齿镊夹捏仍可引起WDR神经元放电增多；〓5〓晚成分放电的潜伏期缩短，即宁静期的时程变短，由给蛇毒前的118.83〓3.67ms降至50.72〓1.36ms〓n〓32，P〓0.01〓；〓6〓在正常动物，如果预先给予只激活A纤维的弱条件电刺激〓mA，100μs〓可抑制随后的伤害性检验刺激所诱发的WDR神经元的晚成分放电，当条件刺激个数从1增加至5时，每次伤害性检验刺激所诱发的晚成分放电数从9.29〓0.97个降至6.71〓0.68个〓n〓8，P〓0.05〓；〓7〓固定条件刺激数为1个，当条件刺激与检验刺激之间的间隔增大时，A纤维条件刺激对WDR神经元晚成分放电的抑制作用逐渐减弱，当条件刺激与检验刺激之间的间隔在50 ms以内时，抑制效应最为显著，此时，晚成分放电数由正常时的12.57〓1.21个降至2.29〓0.42个〓n〓11，P〓0.01〓；〓8〓与急性研究中的WDR神经元电活动的变化结果相匹配，利用蛇毒制备的大鼠模型在行为学上表现为热痛觉过敏、冷觉的痛性感觉异常及机械痛觉过敏等慢性痛症状。

What are your goals and strategies for growth?

你的成长目标和策略是什么？

And unto the angel of the church in Sardis write; These things saith he that hath the seven irits of God, and the seven star I know thy works, that thou hast a name that thou livest, and art dead.

3：1 你要写信给撒狄教会的使者，说，那有神的七灵和七星的，说，我知道你的行为，按名你是活的，其实是死的。