形态发生的

The inhibin a gene、 the bone morphogenetic protein 4 (BMP4) gene and the bone morphogenetic protein 7 (BMP7) gene were studied as candidate genes on the prolificacy of Small Tail Han sheep. Single nucleotide polymorphisms of 5 ' regulatory region、 exon 1 of INHA gene;exon 2、 exon 3 and exon 4 of BMP4 gene and exon 2、 exon 3 of BMP7 were detected in high fecundity breed and low fecundity breeds (Chinese Merino sheep, Corriedale sheep and South African Mutton Merino sheep) by PCR-SSCP. The results indicated that there was a mutation (316C→T) in 5' region of INHA gene in Small Tail Han sheep, Chinese Merino sheep and Corriedale sheep, the same mutation did not exist in South African Mutton Merino sheep.

采用PCR-SSCP技术检测抑制素α(inhibin α，INHA)基因5'调控区、外显子1，骨形态发生蛋白4(bone morphogenetic protein 4，BMP4)基因外显子2、外显子3和外显子4以及骨形态发生蛋白7(bone morphogenetic protein 7，BMP7)基因外显子2和外显子3在高繁殖力绵羊品种以及低繁殖力绵羊品种(中国美利奴绵羊、考力代绵羊、南非肉用美利奴绵羊)中的单核苷酸多态性，同时研究这三个基因对小尾寒羊高繁殖力的影响。

Bone morphogenetic protein gene in bone tissue engineering for bone defect has become a new hot study currently.

骨组织中的骨形态发生蛋白以及骨形态发生蛋白的表达和功能由于他们显著的生物学作用而被长时间的研究。

It is prepared with phosphatide with excellent biocompatibility and cell compatibility as dispersant, protein and polysaccharide as medicine wrapping material and through co-agglomeration process with control proportion among protein, polysaccharide and bone morphogenetic protein.

它是利用具有良好的生物相容性与细胞相容性的磷脂类物质为分散剂，以蛋白、多糖为药物的包覆材料，通过控制蛋白、多糖的比例以及他们的混合体与骨形态发生蛋白的比例，采用共凝聚技术，获得粒径40～2000nm的水分散的骨形态发生蛋白注射制剂。

ABSTRACT : Bone morphogenetic proteins have been identified as important morphogens with pleiotropic functions in regulating the development, homeostasis and repair of various tissues.

骨形态发生蛋白被认为重要的形态发生素，有着多效的作用，在调节各种组织发育，内环境稳态和修复。

Result showed that the epidermis dominant the morphogenesis changes. Mesenchymal is subdominant.β-catenin expression begin from horny placode epidermis stage and go up increasingly to peak value and maintain in hair follicle. The range of mesenchymal change is less.

结果表明，牦牛角的形态发生按照角基毛囊和角质外鞘发生与否分为5个阶段：角原基前期(Ed≤60)表皮增厚，无毛囊发生；角原基中期(Ed60~140)表皮持续增厚，有少量毛囊发生；角原基后期(Ed140~250)表皮变薄，大量毛囊发生；肉角期(≤0.5 a)真皮乳头发生；成角期(≥0.5 a)形成角质外鞘。

The epidermis dominant the changes. Mesenchymal is subordination.β-catenin expression begin from placode epidermis stage and go up increasingly as well as peak value maintain to hair follicle. The range of mesenchymal change is less. SHH expression transform is dramatically to stimulate the placode-germ-peg-hair follicle.

结果表明，在睫毛毛囊的形态发生中表皮－间充质相互作用以表皮为主导间充质随着表皮而变化，β-catenin从基板表皮开始表达，逐渐增强，从毛芽至形成毛囊维持高水平，间充质变化幅度较小；Shh则在睫毛形态发生中变化剧烈，刺激基板－毛芽－毛钉－毛囊。

The Results displayed: DChanges of histological morphology in treating group is superior to the other two groups.(2Expression of BMP-2 at fracture region in treating group is obviously supeior to the other two groups(p.05) and advancely reach peak valuce at first weak.(3) transcriptional level of BMP-2 mRNA in treating group is obviously supeior to the other two groups(p.05) and samely advancely reach peak valuce at first weak.(4)In every period of fracture healing, the expression of BMP-2 and transcriptional level of BMP-2 mRNA appear dynamic change and begin to go up after fracture, moreover reached to peak value in two weaks, then go down gradually.

结果发现：(1)治疗组组织形态学检查明显优于其它二组；(2)治疗组骨折部位骨形态发生蛋白-2(BMP-2)的表达水平比其它二组明显提高(P＜0.05)，并在一周时提前达到高峰；(3)治疗组骨折部位骨形态发生蛋白-2(BMP-2)mRNA的转录水平比其它二组明显提高(P＜0.05)，同样在一周时提前达到高峰；(4)在骨折愈合的不同时期，BMP-2的表达及其mRNA的转录水平呈动态变化，即骨折后开始升高，2周左右达到高峰，以后逐渐下降。

AIM: Bone morphogenetic protein as polyphenic morphogen can induce the formation of bone and cartilage.

目的：研究证实，骨形态发生蛋白是多效性的形态发生素，在一定环境下，可诱导骨与软骨的形成。

Sequence of appearance and transformations of morphological structures during larval and juvenile mytilids life histories have been examined. Ontogenies of about 60 taxa were typified into 4 morphogenetic patterns, or modes.

作者对贻贝科贝类的幼虫和幼贝期发育阶段形态结构的出现和变化顺序进行了研究，其约60个不同分类单元的个体发生可归纳为4类形态发生类型或模式。

Objective To investigate the biomechanical behavior of injectable recombinant human bone morphogenetic protein-2 (rhBMP-2)/calcium phosphate cement used in vertebroplasty in primate models. Methods Two fresh cadavers of adult rhesus were used as group Ⅰ, and 4 adult rhesuses were divided into groups Ⅱ and Ⅲ.

复合重组人骨形态发生蛋白-2的可注射磷酸钙骨水泥在椎体成形术中的目的探讨自主研发的复合重组人骨形态发生蛋白－2(rhBMP-2)的可注射磷酸钙骨水泥应用于猕猴椎体成形术早期和后期生物力学性能。

Methods: Five patients with parkinsonism or dystonia were assigned to general anesthesia using an modified endotracheal tube.

本实验依照人体实验之相关规定进行，五位患有帕金森氏症或肌张力异常的病人接受神经立体定位手术。

If you can benefit from this book, it is our honour.

如果您能从本书获益，这将是我们的荣幸。