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Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Instead, however, of ascribing purpose in a vague, unsatisfactory manner to nature itself, the Scholastics attributed design to the intelligent, provident author of nature.

相反，不过， ascribing的目的，在一个空泛的，不理想的方式本身的性质， scholastics归因于设计的智能，和作者的性质。

In this way, the value form of capitalist modes of production is fetishized,and the real essence of exploitation of it is concealed. In addition, Marx pointed out the revolutionary road that is to change the defective reality, to utterly debunk ideology that shelters the truth and acquire the true knowledge about reality. The primary spirit of Marxism is to pursuit the dialectical unity of theory and practice.

马克思揭示了资本主义商品世界的宗教性质，说明商品拜物教及其理论表达是资本主义生产方式的必然产物，它用物际关系代替并掩盖了人际关系，把商品、货币、资本的社会属性归因于纯粹的物的属性，从而掩盖了资本主义生产方式的剥削本质，只有变革有缺陷的现实才能彻底祛除意识形态对现实的蒙蔽，达到对现实的真实认识。

The mechanism of the platinum recovery is related to the surface state of the palladium, and the high recovery rate by the palladium alloy catchment gauzes is attributted to this unique multilayer structure and to the ability of palladium to reduce platinum oxide.

Pd合金捕集网回收铂的机制与Pd的表面状态有关，它的高的回收率归因于这种独特的多层结构和Pd对PtO2的还原能力。

To the number of updatein DirectX 10.1 can be attributed the possibility to assign the independent regimes of blendingfor different render-target, the required requirement of support MSAA with a quantity of simpleis not less than four, the appearance of control capability of arrangement of those selected sub-Sampilau from shader, a larger quantity of input and output registers in vertex shader, a increase in the accuracy of calculations, the filtration FP32 size, the massifs of cubic textures.

以人数更新directx的10.1可以归因于可能指派独立政权的配煤不同，使目标，所需要的要求，支持msaa与数量的简单不得少于四，外观控制能力的安排，被选中的分sampilau从着色，更大数量的输入和输出寄存器顶点着色引擎，一增加，在精度估算，过滤fp32大小， massifs立方织构。

At low temperature, both the positive and negative magnetoresistance effect can be observed for all the samples. The s-d exchange interaction induced spin-splitting, the formation of bound magnetic polarons, and the magnetic field suppressed spin-disorder scattering were competed for the MR behavior.

另外，在低温时所有样品都表现出较大的正磁电阻，我们认为正磁电阻效应是由于s-d电子交换相互作用引起的自旋劈裂造成的，而高场时出现的负磁电阻效应则可能归因于磁场导致的束缚磁极化子的破损和自旋散射的抑制。

The Ophites possessed "thousands" of apocrypha, as Epiphanius tells us; among these he specially mentions:"Questions of Mary, great and small"(some of these questions are perhaps extant in the Pistis Sophia); also many books under the name of "Seth","Revelations of Adam", Apocryphal Gospels attributed to Apostles; an Apocalypse of Elias, and a book called "Genna Marias".

该ophites拥有&千& apocrypha ，埃皮法尼乌斯告诉我们；其中他特别提到：&问题的玛丽，大和小&（一些对这些问题的也许是，在现存的信实的索菲亚）；也有很多书籍的名义下，&塞思&，&启示亚当&，猜测福音归因于使徒；一的启示埃利亚斯，和一本书，所谓元和

Resistant starch from extrudate containing guar gum showed higher swelling and solubility. This was attributed to frictional forces created by the gum, which contributed to the loosening of granular structure.

含有瓜尔豆胶的挤出物中的抗性淀粉具有较高的溶胀性和溶解性，这可归因于胶产生的摩擦作用及其导致的颗粒结构的松散。

Objections to the first include the claim that gratitude pre-supposes motives on the part of the benefactor which cannot be imputed to institutions, the further claim that the metaphysics of the state makes the state an inappropriate object of gratitude, and the democratic intuition that the state should not be regarded as Lady Bountiful.

针对第一个论点的反对意见包括这样一种看法：感恩预设了施惠者的动机，而这些动机是不能归因于机构的；进一步的反对指出：国家的形而上学性使国家不适于作为感恩的对象，因为显然能直觉的是，国家不应当被看作一位&慷慨的夫人&。

In time, however, the translations made from the Greek revealed an Aristotle free from the errors attributed to him by the Arabians, and, above all, the commanding genius of St. Albertus Magnus and his still more illustrious disciple, St. Thomas Aquinas, who appeared at the critical moment, calmly surveyed the difficulties of the situation, and met them fearlessly, won the victory for the new philosophy and continued successfully the traditions established in the preceding century.

在时间，不过，翻译从希腊发现亚里士多德免费从错误归因于他由阿拉伯人，以及上述所有，指挥的天才圣阿尔伯图斯马格努斯和他的仍是更多的杰出弟子，多瑪斯，谁出现在关键时刻，冷静地进行调查的困难情况，并会见了他们无畏无惧地赢得了胜利，为新的哲学，并继续成功的传统，建立了在前面的世纪。

Methods: Five patients with parkinsonism or dystonia were assigned to general anesthesia using an modified endotracheal tube.

本实验依照人体实验之相关规定进行，五位患有帕金森氏症或肌张力异常的病人接受神经立体定位手术。

If you can benefit from this book, it is our honour.

如果您能从本书获益，这将是我们的荣幸。