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Iwill laugh at my failures and they will vanish in clouds of newdreams; I will laugh at my successes and they will shrink to theirtrue value. I will laugh at evil and it will die untasted; I willlaugh at goodness and it will thrive and abound.

我笑自己的失败,它们将化为梦的云彩;我笑自己的成功,它们回复本来面目;我笑邪恶,它们远我而去;我笑善良,它们发扬光大。

Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章:第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述;第二章研究了磷脂-桐酸脂质体的稳定性,通透能力及桐酸的聚合对这些性质的影响;磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体,〓的作用首先是使脂质体集聚然后使脂质体融合,并加速内包荧光物的释放;第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA,DDOL,研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响,聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性;第四章合成了两类氨基酸为极性基团的双亲分子,它们均可以在超声下形成稳定的脂质体结构;氨基酸基团可以在脂质体上进行缩聚反应,若聚合后脂质体表面仍有足够的亲水能力,则可得到稳定的多肽型脂质体;聚合后脂质体的相变温度降低,通透能力增加;第五章合成了四种亲水基团为单糖基的双亲分子GL-l,GL-2,GL-3, GL-4,研究了它们在水中的分散情况、集合体形态与分子结构的关系;在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高,阻止脂质体在低温放置时的集聚与融合;第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1,CL-2,CL-3;它们可以象胆固醇一样与磷脂混合形成稳定脂质体,胆甾环基团位于脂质体双分子层膜的中间;与胆固醇的作用相反,它们可以增加磷脂双分子层膜的流动性,降低混合脂质体的相变温度;三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关,比膜厚度短的分子影响最大。

Unicorn fish are generally nonaggressive, but during a rare fight they defend themselves with forward-pointing prongs on either side of their tails rather than the prominent horn on their heads.

独角兽鱼一般是不侵略的,但在一个罕见打架期间它们防卫它们自己用向前的尖头叉子在两个边上的它们的尾部而不是突出的角在它们的头部。

But now they are generally chang'd to worse Uses; they make the Fancy disgust the best Things, if they come found and unadorn'd ; they are in open Defiance against Reason; professing not to hold much Correspondence with that; but with its Slaves, the Passions; they give the Mind a Motion too changeable and bewitching, to conflict with right Practice.

但现在,它们大多改作较坏的用途;如果它们被找到却不受赞赏,就会让臆想败坏最好的事物;它们公然蔑视理性;宣称与理性异趣;却与理性的奴隶,激情,沆瀣一气;它们赋予心灵一种过于善变和魅惑的举动,与正确的行为抗衡。

With it different is several flies, they all departed in the short several minutes the jar, because they certainly do not face the unidirection to fly, they attempt in every way, although unavoidably runs into a wall, but they obtained the success □□to be free.

与之不同的是几只苍蝇,它们在短短的几分钟内全都飞出了瓶子,因为它们并不朝着同一方向飞,它们多方尝试,虽免不了碰壁,但是它们获得了成功——自由。

We kept our Arms ready, and our Eyes about us, but we saw no more Wolves,'till we came thro' that Wood, which was near half a League, and entred the Plain; as soon as we came into the Plain, we had Occasion enough to look about us: The first Object we met with, was a dead Horse; that is to say, a poor Horse which the Wolves had kill'd, and at least a Dozen of them at Work; we could not say eating of him, but picking of his Bones rather; for they had eaten up all the Flesh before We did not think fit to disturb them at their Feast, neither did they take much Notice of us: Friday would have let fly at them, but I would not suffer him by any Means; for I found we were like to have more Business upon our Hands than we were aware of.

我们手里紧握着枪,眼睛紧盯着四面八方。可是在我们穿过那座一英里多长的树林,进入平川地以前,再也没有看见过别的狼。等我们一进入平川,向四下一望,头一眼就见到一匹死马。这是一匹被狼群咬死的马,同时见到至少有十二条狼在那里大吃特吃;其实,马肉早就给它们吃光了,现在正在啃马骨头呢!我们感到不应该去打扰它们的盛宴,何况它们也没有注意我们。星期五本来想向它们开枪,可是我怎么也不同意。因为我感到,我们的麻烦还在后面呢,尽管我们现在还不知道。

Taken by themselves, they do but seem to be what they are not; they look like virtue at a distance, but they are detected by close observers, and in the long run; and hence it is that they are popularly accused of pretense and hypocrisy, not, I repeat, from their own fault, but because their professors and their admirers persist in taking them for what they are not, and are officious in arrogating for them a praise to which they have no claim.

就其本身而言,它们似乎已远非其本来面目,远观之下,它们似乎是美德,然而,只有通过长期的近距离仔细观察方可探知其真伪。也正因为此,各种美德品质受到广泛的责难,指责其虚饰与伪善。我要强调,这绝非是因为其自身有什么过错,而是因为它们的信仰者和赞美者们一味地把它们弄得面目全非,并且还要好事地献上其本身并不希冀的赞颂。

Taken by thelves, they do but seem to be what they are not; they look like virtue at a distance, but they are detected by close observers, and on the long run; and hence it is that they are popularly accused of pretense and hypocrisy, not, I repeat, from their own fault, but ause their professors and their admirers persist in taking them for what they are not, and are officious in arrogating for them a praise to which they have no claim.

就其本身而言,它们似乎已远非其本来面目,它们似乎一远看的美德,经久久细察方可探知。因此它们受到广泛的责难,指责其虚饰与伪善。我要强调,这绝非是因为其自身有什么过错,而是因为教授们和赞美者们一味地把它们弄得面目全非,并且还要殷勤地献上其本身并不希冀的赞颂。

Taken by themselves, they do but seem to be what they are not; they look like virtue at a distance, but they are detected by close observers, and on the long run; and hence it is that they are popularly accused of pretense and hypocrisy, not, I repeat, from their own fault, but because their professors and their admirers persist in taking them for what they are not, and are officious in arrogating for them a praise to which they have no claim.

就其本身而言,它们似乎已远非其本来面目,它们似乎一远看的美德,经久久细察方可探知。因此它们受到广泛的责难,指责其虚饰与伪善。我要强调,这绝非是因为其自身有什麽过错,而是因为教授们和赞美者们一味地把它们弄得面目全非,并且还要殷勤地献上其本身并不希冀的赞颂。

Taken by themselves, they do but seem to be what they are not; they look like virtue at a distance, but they are detected by close observers, and in the long run; and hence it is that they are popularly accused of pretense and hypocrisy, not, I repeat, from their own fault, but because their professors and their admirers persist in taking them for what they are not, and are officious in arrogating for them a praise to which they have no claim.

唉,当他们用它伪装起来时,就更增加了他们外表上的冷静、快活和魅力。就其本身而言,它们似乎已远非其本来面目,它们似乎一远看的美德,经久久细察方可探知。因此它们受到广泛的责难,指责其虚饰与伪善。我要强调,这绝非是因为其自身有什么过错,而是因为教授们和赞美者们一味地把它们弄得面目全非,并且还要殷勤地献上其本身并不希冀的赞颂。

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Yes,In fact,I'm on our city ream.

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