学位

To elucidate the molecular mechanisms underlying the neural plasticity after CNS injury, the gene expression profile in the rat hippocampus following perforant path transections was explored by several methods including custom differential screening, custom cDNA array and cDNA microarray. Of 2300 cDNA clones from low-abundance rat brain cDNA bank, 6 were identified as differentially expressed genes/ESTs in the hippocampus 35 days after lesion, in which none was confirmed by Northern blot. Of 8000 cDNA elements, custom cDNA array identified 47 as differentially expressed genes/ESTs with above 3-fold changes in the hippocampus 35 days after lesion, in which 25 were up-regulated and 22 down-regulated.

中文题名去传入海马的差异表达基因筛选和Cystatin C表达副题名外文题名 Screening of the differentially expressed genes and cystatin C expression in the deafferented hippocampus 论文作者应国新导师周长福研究员学科专业神经生物学研究领域\研究方向学位级别博士学位授予单位中国科学院上海生命科学研究院学位授予日期2002 论文页码总数121页关键词海马星型胶质细胞 Cystatin C 基因表达去神经海马馆藏号BSLW /2003 /Q42 /27 为了阐明中枢神经系统损伤后神经可塑性的分子机制，本实验探索了多种方法，包括传统差异筛库、传统cDNA array和cDNA microarray，对穿通纤维切断后大鼠海马的基因表达图谱进行了研究。

In order to study novel polyquinolines for their applications in the fields of electroluminescent devices and chemosensors, we synthesize polyquinolines containing phenylamine moiety for single-layer LEDs; moreover, we synthesize polyquinolines with different molecular structures to investigate their properties as fluorescent chemosensors.

中文题名聚喹啉的合成与表征副题名外文题名 Synthesis and characterization of novel polyquinolines 论文作者童辉导师王利祥学科专业高分子化学与物理研究领域\研究方向学位级别博士学位授予单位中国科学院长春应用化学研究所学位授予日期2002 论文页码总数152页关键词发光材料共轭聚合物荧光传感器电致发光聚合物聚喹啉馆藏号BSLW /2003 /O633 /17 本论文是以研究新型聚喹啉材料在电致发光和荧光传感器方面的应用为目的，将芳胺基元引入到聚喹啉主链上，以期使聚喹啉可用于单层电致发光器件中；同时通过合成不同分子结构的聚喹啉来考察其作为荧光传感器的性能和规律。

The human cartilages are composed of chondrocyte and extracellular matrix , the form of chondrocytes are hypertrophy and the quantity are less; the ECM of cartilage are compised of type Ⅱ collagen and proteoglycan. Articular cartilages are all hyaline with little fibers. Trauma and arthritis are the main cause of cartilage injury, the ommilayer injury ofcartilage can be recovered by marrow, but because of without stimulation mechanism, the new tissues are merely fibrocartilages, they can not be coincide with hyaline cartilage in menchanics; the purely damage of articular cartilage can not stimulate chondrocyte to regenerate because of without blood circulation, thus, the plerosis of articular catilage can not depend on the proliferation of local chondrocyte. Ever since, people tried their best to find a way to reconstruct articular cartilage.

中文题名人骨髓基质干细胞成软骨诱导及多孔复合材料作为细胞载体的体外实验研究副题名外文题名 Cartilage induction of human mesenchymal stem cells and experiment on compound porous materials as cells' scaffold in vitro 论文作者刘晓岚导师周江南学科专业外科学研究领域\研究方向学位级别博士学位授予单位中南大学学位授予日期2003 论文页码总数68页关键词骨组织工程软骨细胞骨髓基质干细胞壳聚糖高分子外消旋聚乳酸馆藏号BSLW /2003 /R68 /10 造成人体关节软骨损伤的原因主要为创伤和关节炎，关节软骨全层损伤可由于骨髓中间充质干细胞的高速增殖修复，但这种修复由于缺乏相应的刺激机制，只能形成纤维软骨，而不能形成符合关节生理、力学要求的透明软骨；单纯软骨部分损伤软骨组织内无血管，软骨细胞迁移迟缓，无法使损伤区域软骨细胞再生，因此，关节炎及关节创伤后的软骨修复不能依赖于软骨细胞的增殖和迁移。

Synthesizing new compounds are always the goal of chemist. Recent ly, the progress of the hydrothermal synthesis method is giving a new method to synthesize new compounds. The hydrothermal synthesis method is prefectly applied to synthesizing the tunnling materials, micro-and meso-porous mat erials as well as some new materials, so this method obtained the intrest of che mist.

中文题名含有杂原子的金属－氧簇(V，Mo，W，P，As)的合成与结构副题名外文题名论文作者李亚丰导师裘式纶教授学科专业无机化学研究领域\研究方向学位级别博士学位授予单位吉林大学学位授予日期2002 论文页码总数70，68页关键词金属－氧簇化学多酸化学无机合成化学馆藏号BSLW /2003 /O611 /3 合成新结构和新组成的化合物一直是化学家们的目标，近代水热合成技术的发展为合成亲新化合物提供了一种新的方法，水热由于在合成具有孔道结构、微介孔材料以及一其它一些新型材料具有其它方法无可比拟的优越性，因此，越来越受到人们的重视。

Orange-spotted grouper is a benthic protogynous marine fish with sex inversion. It is one of the most important culturing fish in the southeast of Asia. As in other vertebrates, its growth is mainly controlled by growth hormone . Few data are available concerning the regulation of GH in grouper. In this paper, the regulation of growth hormone release from pituitary of orange-spotted grouper and its mRNA level was determined by radioimmunoassay and RNase protection assay.

中文题名斜带石斑鱼生长激素分泌及其基因表达调控的研究副题名外文题名 Regulation of growth hormone and its gene expression in orange-spotted grouper，Epinephelus coioides 论文作者冉雪琴导师林浩然学科专业水生生物学研究领域\研究方向学位级别博士学位授予单位中山大学学位授予日期2003 论文页码总数140页关键词生长激素基因表达石斑鱼馆藏号BSLW /2003 /Q959 /39 应用分子克隆技术，构建了斜带石斑鱼生长激素(Growth hormone，GH)基因重组质粒，在大肠杆菌细胞中获得高效表达，亲和层析纯化斜带石斑鱼GH融合蛋白做为抗原，免疫家兔制备特异性抗体，通过酶联免疫实验、放射免疫测定、离体脑垂体静态孵育和液相杂交／核糖核酸酶保护试验及化学发光检测技术，研究了斜带石斑鱼GH分泌及其mRNA表达的调控机制，对于斜带石斑鱼的生长、繁殖、人工养殖等具有重要意义。

Three infectious bronchitis virus isolates named as Q1, J2 and T3 were isolated from proventricular tissue taken from vaccinated chicken flocks in China The biological characteristics of the three isolates were observed.

中文题名传染性支气管炎致腺胃病变毒株变异的分子基础及我国和东南亚分离株的分子流行病学研究副题名外文题名 Molecular basis for variation of proventriculus pathogenic IBV isolates and molecular epidemiology of IBV isolates from China and southeast Asia 论文作者蒋贻海导师陈溥言教授学科专业预防兽医学研究领域\研究方向动物分子病毒学及免疫学学位级别博士学位授予单位南京农业大学学位授予日期2002 论文页码总数127页关键词鸡传染性支气管炎传染性支气管炎病毒腺胃毒株馆藏号BSLW /2003 /S855 /9 从我国接种过传染性支气管炎疫苗的幼鸡群的腺胃组织中分离得到三个传染性支气管炎毒株Q1、J2和T3，并对它们的部分生物学特性进行研究。

Completely different crystal structures and morphology were shown in the meltdrawn films of two kinds of tacticity of sPP. A continuous conformational transform from the 〓 into the of sPP was induced by further stretching. While the zigzag conformation can retransform back to helical 〓 one after annealing above 80℃, the mechanism of conformation transform has been introduced.

Petermann教授学科专业高分子化学与物理研究领域\研究方向学位级别博士学位授予单位中国科学院长春应用化学研究所学位授予日期2001 论文页码总数114页关键词聚丙烯聚丁烯共聚物聚α-烯烃馆藏号BSLW /2003 /O632 /3 用电子显微学、电子衍射、DSC和FTIR等技术对聚α-烯烃及其共聚物的晶体结构和相转变行为进行了系统地研究，包括间同立构聚丙烯、全同立构和间同立构聚丁烯-1（iPB-1，sPB-1）、以及丙烯-丁烯-1间同立构共聚物。

Yanbian region lies in the eastern segment of north margin of North China slab, situating on the intersect point of North China, Sibiric and the pacific slab. Space and boundary of these slabs controls the Mesozoic volcanic-subvolcanic rock distribution, which restricts the epithermal-porphyry gold metallogenic series. Though many research of deposits have been done individually, the synthesize works are few.

中文题名延边地区浅成低温热液－斑岩型金成矿系列副题名外文题名 The epithermal-porphyry gold deposit series in Yanbian region 论文作者梁俊红导师金成洙王建国教授学科专业矿产普查与勘探研究领域\研究方向学位级别博士学位授予单位东北大学学位授予日期2002 论文页码总数112页关键词成矿系列金矿床延边地区馆藏号BSLW /2003 /P618.51 /1 延边地区处于华北板块北缘东段，正好位于华北板块、西伯利亚板块和濒太平洋构造三大构造区域之间的三联点处，三者所处的空间位置和边界条件，对延边地区的火山—次火山岩及与之有成生联系的金成矿系列的形成和演化起着明显的控制作用。

Objective: To explore the mechanisms resulting in the recurrence of urethral scar which make urethral strictures difficult to be cured, a series experiments were conducted to find potential effective factors involved in urethral scar formation and degradation, including the studies of extracellular matrix component of urethral stricture scar, the characteristics of urethral scar fibroblast, and the effects of urine on urethral fibroblast in vitro, as well as the studies to compare the difference of collagenase activity, type Ⅰ collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the tissues and cultured fibroblasts from normal urethra and strictured urethra respectively, and the studies to investigate the effect of antisense TIMP-1 oligodeoxyonucleotide on cell proliferation and collagenase activity of urethral scar fibroblast.

中文题名尿道瘢痕基础研究副题名胶原酶活性，TIMP-1的表达及其反义基因治疗外文题名 Experimental study on urethral scar-activity of collagenase，expression of TIMP-1，and antisense TIMP-1 gene transfection of urethral scar fibroblast 论文作者黄翔导师杨宇如教授学科专业外科学研究领域\研究方向学位级别博士学位授予单位四川大学学位授予日期2002 论文页码总数104页关键词尿道手术瘢痕胶原酶成纤维细胞尿道瘢痕馆藏号BSLW /2003 /R699 /12 目的：研究尿道瘢痕的细胞外基质的组成，尿道瘢痕成纤维细胞的生物学特性以及尿液对其生长的影响；比较胶原酶活性，金属蛋白酶组织抑制因子-1（TIMP-1）以及Ⅰ型胶原含量在尿道瘢痕和正常尿道组织及体外培养的成纤维细胞中的差异；研究反义TIMP-1寡核苷酸对尿道瘢痕成纤维细胞增殖以及胶原酶活性的影响。

Ph.D. Degree examination committee consists of one STUT members and four non-STUT members.

五、博士班学位考试委员：校内学位考试委员设一人，校外学位考试委员设四人。

Methods: Five patients with parkinsonism or dystonia were assigned to general anesthesia using an modified endotracheal tube.

本实验依照人体实验之相关规定进行，五位患有帕金森氏症或肌张力异常的病人接受神经立体定位手术。

If you can benefit from this book, it is our honour.

如果您能从本书获益，这将是我们的荣幸。