受体部位

The effects, of protection and treatment with, combined Ch, NaF and a trophie were significantly better than that with atropine alone. In isolated phrenic nerve-diaphragm preparation of rat, isolated jejuneal preparation of, guinea pig, and the metabolic experiment of rat liver, the results of the, assay on the rat blood ChE activity indicated that antidotal effect of NaF may be due to the antidese...

大鼠离体膈神经膈肌、豚鼠离体空肠和大鼠肝脏代谢实验及对大鼠全血胆碱酯酶活力测定的结果表明，NaF的抗毒作用可能是由于其对神经肌肉接头和/或神经节中的N受体的抗脱敏作用；而Ch则可能通过其对ChE的保护和/或加速被抑制ChE的复能，阻碍Ach到达M受体部位而发挥作用。

Mu opioid receptor was not observed in the wrist, funnel, abdomen of mantle, mouth, craw, stomach theca, intestine, rectum, sialoid gland, liver. Weak positive mu opioid receptor immunoreaction was found in inner epidermis, ectoblast, connective tissue of the esophagus and the keratolytic of the stomach and positive immunoreaction in epidermis of back of mantle and membrane of wrist.

结果表明，短蛸腕、漏斗、外套膜腹面、口球、嗉囊、胃盲囊、肠、直肠、前唾液腺、后唾液腺、肝胰脏均呈μ受体阴性，但食道内上皮、外膜、结缔组织和胃角质层有μ受体分布，外套膜背面、腕间膜的上皮或近上皮部位呈μ受体阳性。

Intravoneous injection of 0.5mg/kgBW jingsongling cause the 60 minutesrelaxation of goat gastric motor.The effects of jingsongling on the gastric motor ofgoat is major of effects of α2 -adrenoceptor agonist,as well as that of α1 -adrenoceptor agonist,the effects of α1 -adrenoceptor agonist concentrate at thecardic and pylorus;the function of α2 -adrenoceptor exit widely at cardic,pylorus,rumen,reticulum,omasum and abomasum,the function at different part is not the same.The lowestdose of jingsonglinginhibiting the amplitude and frequency of the gastricmyoelectric is 0.01mg/kgBW;the influence of jingsonglingto the gastricmotility of goat is dose-dependent,and the amplitude regain after the frequency ofgastric myoelectriv wave.When the goat revived,the gastric motor function is notreach the level of the normal;the major reason ofjingsongling cause the goat gastricrelaxation is the amplitude renew slowly.The intravoneous injection ofjingsonglingfirst,after 5 minutes,intravoneous injection the antagonist,the effect of prazosin and idazoxan mixed is best,which can fast reversal of theinhibition of jingsongling on the gastric motor of goat,the effects of idazoxan isgood,and the prazosin block the effection of jingsongling is better than that ofxylazine,especially at cardia and pylorus.When intravoneous injection of0.5mg/kgBW idazoxan and/or prazosin only,the amplitude of gastric myoelectric ingoat increases at a certain degree,but the frequency is not changed.

静脉注射0.5mk/kgBW的静松灵引起山羊胃蠕动弛缓长达60分钟；静脉注射0.5mg/kgBW的静松灵对山羊胃蠕动机能的影响是以α2肾上腺素受体作用为主的，兼有α1肾上腺素受体的作用，而且静松灵的α1肾上腺素受体的作用主要集中在幽门和贲门；α2肾上腺素受体的作用广泛存在于贲门、瘤胃、网胃、瓣胃、皱胃和幽门中，不同部位间有功能上的差异；静注0.01mg/kgBW的静松灵是对山羊的贲门、瘤胃、网胃、瓣胃、皱胃和幽门的肌电波频率和振幅均产生影响的最低剂量；静注一定剂量的静松灵对山羊胃蠕动的抑制作用与剂量呈相关性；而且山羊胃肌电波振幅的恢复比肌电波频率的恢复慢；苏醒时山羊的胃蠕动机能尚未恢复到正常状态；静松灵引起山羊胃弛缓的主要原因是由于胃肌电波的振幅恢复慢；静注0.5mg/kgBW的静松灵，5分钟后静注0.5mg/kgBW的拮抗剂时，咪唑克生+哌唑嗪的作用最好，能迅速地逆转静松灵对山羊胃蠕动的抑制作用，咪唑克生也有很强的拮抗作用，而哌唑嗪对静松灵的拮抗效果好于对隆朋的拮抗；单独静注0.5mg/kgBW的咪唑克生和/或哌唑嗪时，山羊的瘤胃、网胃、瓣胃、皱胃、贲门和幽门的肌电波振幅有一定程度的增强，而肌电波频率未见变化。

This suggested that the mechanism of alleviating asthma was that when drugs were combined with the active part ofβ2 receptor ,the conformation of receptor was changed and receptor was activated,spasm of bronchial smooth muscle was alleviated,of which relieved edema of air passage、restrained inflammatory cell and so on,these would contribute to pursiness.

这表明，麻杏石甘汤的平喘机制应该是通过和β2受体活性部位结合，改变了受体的构象，受体被激活，使得支气管平滑肌松弛，减轻了气道水肿，抑制了炎症细胞等，有利于缓解和消除喘息。

Puzzlingly, such effect is transient and depression is usually reinstated after the first episode of recovery sleep, or even after short naps .

睡眠剥夺可能通过改变5-羟色胺(serotonin 5-HT)系统起作用，5-HT_(1A)受体作为突触前的自身受体在调节中缝核5-HT神经元的活性中发挥着关键作用，并且作为突触后受体介导5-HT对边缘系统、皮层、下丘脑及其它一些脑区部位的作用，使得5-HT_(1A)受体的调节对于精神疾病非常重要。

The calculation can take up to 45 minutes, but needs to be done only once for each receptor site.

计算需要占用45分钟，但对每个受体部位只需要做一次。

A noncompetitive antagonist prevents the agonist from producing any effect at a given receptor site.

非竞争性拮抗剂可阻止激动剂在特定受体部位产生任何效应。

According to the prediction results of secondary structure of receptor β chain, the general theory about relationship between cytokine and its receptor at binding site and blocking results of polyclonal antiserum against D1 (9～114 residure of β chain), the new three peptides, which comprised residures of 45～75, 56～75 and 66～75, were designed and synthesized.

依据对受体β链二级结构的预测、受体与细胞因子结合部位的结构理论以及抗受体β链D1(9～114)片段多克隆抗血清有阻断GM-CSF促进DMSO诱导HL60细胞增殖活性的结果，设计和固相合成了受体β链第45～75，56～75和66～75三个人工合成多肽片段。

The potency of morphine and the competitivity of the blockingeffect points to a specific mechanism at a receptor site ratherthan an unspecific membrane effect.

吗啡的效能竞争性制作用说明了吗啡作用于某一受体部位的机制，而非对细胞膜的非特异性作用。

Immunohistochemical study showed that ER and PR were mainly localized in karyon of epithelial and stroma cell, and also in smooth muscle cell in all specimen. Marked difference of intense staining was observed between implantation site and non-implantation site in the same patient, and the latter is stronger for both ER and PR . There are significant difference between implantation site and non-implantation site for ER expression or PR expression (t=- 3.895, p=0.001; t=- 3.574, p=0.001, respectively).

第一部分输卵管妊娠种植部位、非种植部位和慢性输卵管炎中雌孕激素受体的表达方法：采用免疫组化方法对30例输卵管妊娠患者的种植部位和非种植部位，12例分泌中期慢性炎症输卵管壶腹部ER、PR的定位及半定量研究，并以17例分泌中期正常壶腹部输卵管为对照。

Cynanchum Lingtai apricot production in the average weight 65 grams, the brightly-colored fruit, juicy rich, sweet-sour taste, sweet from the nucleolus, when the late Qing Dynasty famous Shaanxi, Gansu provinces, the Qing imperial court Tongzhi tribute for years.

灵台生产的牛心杏平均单果重65克，果实色泽鲜艳，汁多味浓，甜酸适口，离核仁甜，清末时就驰名陕、甘两省，清同治年间曾为朝廷贡品。

Chenopodium album,Solanum nigrum, and Amaranthus retroflexus were very susceptible to the herbicides. Polygonum persicaria and Abutilon theophrasti were relatively less susceptible to the herbicides, and Lycopersicon esculentum was not susceptible to it. The relationship between reduction rates of weed biomass and PPM values of weed leaves 2,4, and 6 days after treatment was established.

供试的6种杂草对该混剂的敏感性存在显著差异：红心藜Chenopodium album、龙葵Solanum nigrum和反枝苋Amaranthus retroflexus对该混剂最敏感，ED90值分别为47.65、71.67和29.17g/hm2；春蓼Polygonum persicaria和苘麻Abutilon theophrasti敏感，ED90值分别为96.91、114.20g/hm2；而番茄不敏感。