发育

I have therefore generated several p130cas RNA interference transgenic lines to determine the possible function of p130cas during neurogenesis. Knockdown of p130cas expression in developing neurons resulted in partial fusion in the commissures axon fascicles of CNS, photoreceptor axon targeting and guidance defects, and bulged synapse boutons at the neuromuscular junction. Moreover, reduced expression of p130cas in sensory organ precursor cells and proneural clusters resulted in bristle development defects.

为了了解p130cas的功能以及更进一步的分析p130cas在神经发育过程所扮演的角色，我建立一系列可以执行RNA干扰技术的转殖果蝇，结果显示在果蝇的神经中降低p130cas的表现会造成腹部神经索中原来排列整齐的commissure axons神经束偶尔会出现不正常的融合；若将p130cas专一地在果蝇眼睛中降低则会造成果蝇视神经突触目标辨识与突触导向的缺陷；而如果局部的运动神经系统中降低p130cas的表现会造成在神经肌肉接点的神经突触有澎大的现象；此外在果蝇的感觉器官前细胞以及原神经细胞丛，降低p130cas的表现则会导致刚毛发育的缺陷。

Jilin province's rural men The female body shape with the process of human growth and development law. 7-18 years of age, with the increase of age, male, female, height, weight, brassieres showed a growing tendency.

1.2005年吉林省农村男、女生的身体形态发育过程符合人体生长发育规律。7—18岁期间，随着年龄的增长，男、女生身高、体重、胸围均呈现不断增长的趋势

The third sand segment of the second member of Qingshankou Formation in Yaoyingtai, Cangling in the south of Songliao Basin mainly belongs to delta front facies, with well developed and rapidly changed sand body. Thus strata are interbedded with sandstone and mudstone with rapid seismic velocity.

松南长岭腰英台地区青山口组二段Ⅲ砂组以三角洲前缘相为主要沉积特征，砂体较为发育，但砂体变化快，地层为砂，泥岩薄互层，地震速度变化快，圈闭类型主要发育构造[CD*2]岩性复合型隐蔽圈闭。

In early development stage, muscarinic agonist carbachol significantly decreased the magnitude of the pacemaker current If but had no effect in late development stage.

我们发现，在胚胎发育的早期阶段，M胆碱能受体激动剂(muscarinic agonist carbachol，CCh)明显抑制If，但在胚胎发育的晚期阶段，CCh对If的抑制作用消失。

Reefs, reef-mounds and lime mud mounds are all carbonate buildups, and the reefs and banks are important targets for petroleum exploration The reefs, banks and mounds should be divided from each other not only in theory, but also in exploration practice, because of so many differences in sedimentary compositions, fabrics, environments, distribution in time and space, and the characteristics of petroleum geology If the original reef or bank itself was fine reservoir rocks, then it would become a better reservoir after the reservoirconstructive diagenesis The formation of a high quality carbonate reservoir is controlled by two factors: the sedimentary microfacies and the reservoirconstructive diagenesis The first is the basis for the formation of a high quality reservoir, and with the high energy reefbank facies as the best; the latter includes the cataclasis, the dolomitization and the karstification The dolomitization and karstification are the best for the formation of a high quality reservoir The karstification has the widest distribution, profoundest effect, and plays a vital role in the high quality reservoir forming The karst types are quite rich in the limestone reef or bank reservoir, including synsedimentary karst, penesedimentary karst, supergene karst and hydrothermal karst, and so does the dolomitization reef or bank reservoir The formation mechanism of synsedimentary karst and penesedimentary karst is related to the short time exposing and leaching of the cyclical highfrequency shallowupward sequence when the reefs or banks are forming The supergene karst is controlled by the exposing and leaching of tertiary cyclic sequence type I interface after the reefs or banks forming Thus, there developed a great deal of secondary corrosion pores, corrosion fractures and huge caves besides some original pores remained in the reef and bank reservoir Scarcely there are any original effective pores in reefmounds and lime mud mounds, especially in senkes among mounds, but secondary pores could be formed by karstification, and there would likely develop source rocks with high organic abundance

礁、礁丘、丘同属碳酸盐建隆，礁、滩是重要勘探目的层。但各自在沉积组分、组构、环境和时空分布，以及油气地质条件上迥然不同，因而无论从理论还是勘探实践上，都有必要将其各成体系划分开来。礁滩自身为好储集岩，当建设性成岩作用叠加后可形成好的储层。碳酸盐岩优质储层形成，主要受沉积微相与建设性成岩作用两大因素控制。前者是基础，并以高能的礁滩相带为最好；后者主要包括破裂、白云石化和溶蚀三大类，并以白云石化或溶蚀为最优，其中的溶蚀分布最广泛、影响最深刻而对优质储层形成起决定性作用。礁滩储层中的古岩溶类型最为丰富多彩，包括同生期、准同生期、表生期和埋藏期热流体岩溶的所有类型，白云岩化礁滩体也不例外。其中，同生准同生期岩溶的形成机制与礁滩沉积时高频层序旋回向上变浅序列的短暂暴露淋溶有关，表生期岩溶则受控于礁滩沉积后三级层序旋回Ⅰ型界面的暴露淋溶。由此，导致礁滩储层中除了可以也是唯一保存原生孔隙外，还发育了次生溶蚀孔洞缝和大型溶洞。礁丘、灰泥丘尤其是丘间洼地中发育高有机质丰度烃源岩；它们自身没有有效的原生孔隙，但岩溶作用可以形成次生孔隙。

On the termination date, the cultured explants were all examined by Western blot, HE and transmission electron microscope. Our results showed that after 12-days in culture, the cultivation treated with AS-ODN reduced the synthesis of AMBN and had a deformed dental cusp with thinner enamel matrix. Ultrastructure analyses showed that there was hardly any cisternae of the rough endoplasmic reticulum in the ameloblasts at the tip of the cusp of AS-ODN treatedexplants. However, on average the enamel matrix was thinner compared with that in the control group. Furthermore, the collagen fibers in extracellular matrix were found disorganized. These findings seemed to provide a direct experimental evidence that tended to indicate that the arrested AMBN translation in cultured tooth germs might result in the delay of the tooth development.

经用Western蛋白印迹检测表明，所设计的反义核酸对AMBN InRNA具有良好的封闭效果并成功阻断了牙胚对AMBN的表达；在缺乏AMBN情况下，与对照组相比，实验组牙胚在体外可以继续生长发育至钟状晚期，出现成釉细胞和成牙本质细胞的分化，成釉细胞可以分化成为分泌期型成釉细胞，胞浆中缺少合成蛋白质所必需的粗面内质网和高尔基氏体，缺乏溶酶体，表明对蛋白合成和脚的能力降低；实验组牙胚有牙尖形成和基质分泌，但牙尖形态异常，基质形成减少，牙尖周围基质最厚处为O.6卜m，明显薄于对照组的5.spin，基质中胶原纤维粗细不等，排列稀疏， 3 第四军医大学硕士学位论文未见钙化现象，充分证明了AMBN在牙胚发育中参与釉质基质形成和矿化过程，影响胶原纤维和牙本质基质的合成，促进成釉细胞对蛋白质的合成和釉质基质蛋白降解。

The discipline plant evolutionary developmental biology has emerged over the last 10 years. It is a major clade of evolutionary developmental biology or evo-devo.

植物进化发育生物学是最近十几年来才兴起的一门学科，它是进化发育生物学的主要分支之一。

Coculture with endometrial epithelial cells can facilitate the development of early mouse embryo in vitro, which can optimize the condition of embryonic development in vitro.

子宫内膜上皮细胞能够促进小鼠胚胎的体外发育，对早期胚胎的体外发育环境具有优化作用。

Light microscope combined with stereological methods were used to observe and analyze renal tissue and corpuscles at different developmental stages in vivo and vitro.

结果 胚龄12天（E12）体外培养发育情况与在体无显著差异，其余各组随胚龄的增加，小鼠肾组织的体外发育呈下降趋势。

After analyzing the difference of sedimentary elements, they sum up that sedimentary gravity flows are the couping result of provenance system, slop type and lake level fluctuation and that the evolution and dominant structural framework of the Liaodong lift control the sedimentary character and distribution characteristics of the gravity flows.

通过沉积要素比较分析，提出了上述重力流的发育是物源系统、坡折类型和湖平面变化耦合作用的结果，辽东凸起的形成演化及以其为主导的构造格局决定着重力流的发育特征及分布规律。

Since historical times,England ,where the early inhabitants were Celts, has been conquered three times .

从有历史以来，英国，在此地早期居住的是凯尔特人，已经被征服了三次。

Bluetooth OBEX File Transfer Enables the sending and receiving of files on your phone via Bluetooth.

蓝牙OBEX文件移动允许经过蓝牙传送和接受文件。。。。