去氧

We investigated constituent of triterpenoid saponins ofAlbizzia, two new compounds together with two known compounds were isolated from Albizzia julibrissin Durazz. by using column chromatography (macroreticular resin, silica gel, Sephadex gel, reverse phase silica gel),preparative HPLC methods et al.On the basis of spectroscopic analysis, including IR,ESI-MS,~1H-NMR,~(13)C-NMR,HMBC,HMQC,~1H-~1HCOSY and chemical methods, the structure of two new compounds were identified as 3 - O -[β-D-xylopyranosyl(1→2)-β-D-fucopyranosyl (1→6)-β- D -2- deoxy - 2 - acetoamidoglucopyranosyl] -21-O-[(6S)-2- trans- 2,6-dimethyl - 6 - O-β- D - quinovopyranosyl -2,7- octadienoyl] - acacic acid- 28 - O-β-D-glucopyranosyl(1→3)[α-L-arabinofuranosyl(1→4)]-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside acacic acid 3- O -β- D- glucopyranosy(1→3)-β- D- fucopyranosl(1→6) [β-D- xylopyranosyl (1→2)]-β-D-glucopyranoside ;two known compounds were acacic acid lactone 3- O -β-D- xylopyranosyl-(1→2)-β-D-fucopyranosl (1→6)- 2-deoxy -2 -acetoamido -β-D- glucopyranoside ; acacic acid lactone 3- O-β-D-xylopyranosyl(1→2)-α-L- arabinopyranosl (1→6)- 2- deoxy - 2- acetoamido -β-D-glucopyranoside . The study lays chemical foundation and chemical reference substance for enhancing quality standard of Albizzia julibrissin Durazz.

本研究论文在综述国内外对合欢属Albizzia三萜皂苷化学成分和药理作用研究进展的基础上，利用传统植化分离手段和现代分离技术，包括大孔树脂、硅胶、葡聚糖凝胶、反相硅胶等柱色谱，制备高效液相色谱法等技术从中药合欢皮中分离得到了4个化合物，其中，2个新化合物和2个己知化合物，并进一步通过现代分析技术IR，ESI-MS，~1H-NMR，~(13C-NMR，HMBC，HMQC，~1H-~1HCOSY等和化学方法鉴定了2个新化合物的结构分别是：3-O-[β-D-吡喃木糖基(1→2)-β-D-吡喃夫糖基(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖基]-21-O-[(6S)-2-反式-2，6-二甲基-6-O-β-D-吡喃鸡纳糖基-2，7-辛二烯酸基]-金合欢酸-28-O-α-L-呋喃阿拉伯糖基(1→4)[β-D-吡喃葡萄糖基(1→3)]-α-L-吡喃鼠李糖基(1→2)-β-D-吡喃葡萄糖苷，金合欢酸3-O-β-D-吡喃葡萄糖基(1→3)-β-D-吡喃夫糖基(1→6)[β-D-吡喃木糖基(1→2)]-β-D-吡喃葡萄糖苷；2个已知化合物结构分别是：金和欢酸内酯3-O-β-D-吡喃木糖基(1→2)-β-D-吡喃夫糖基(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖苷，金和欢酸内酯3-O-β-D-吡喃木糖基(1→2)-α-L-吡喃阿拉伯糖基(1→6)-β-D-2-去氧-2-乙酰氨基吡喃葡萄糖苷。

Assuming phenylephrine100 g to be approximately equipotent to ephedrine 8 mg,the groups contained the proportional potency equivalent of100%, 75%, 50%, 25% or 0% of phenylephrine and 0%, 25%, 50%,75% or 100%, respectively, of ephedrine.

假设100ug 去氧肾上腺素约相当于8mg 麻黄碱，那么五组混合物中就分别含有去氧肾上腺素等效剂量100%、75%、50%、25%或0%及麻黄碱0%、25%、50%、75%或100%。

Methods Naloxone was synthesized starting from oxidation of thebaine, followed by hydrogenation, acylation, cyanidation, O-demethylation, hydrolyzation and N-allylation. The alternative method of O-demethylation, methane sulfonic acid/DL-methionine and hydrobromic acid were investigated.

在以蒂巴因为原料，经氧化、氢化、酰化、氰化、去氧甲基、水解、N-烯丙基化得到纳洛酮的合成路线中，分别采用甲磺酸／DL-甲硫氨酸和氢溴酸代替三溴化硼进行去氧甲基化和后续水解反应。

The taurohyodeoxycholic acid was synthesized by aminolysis of sodium taurine with carboxy-carbonate mixed anhydride prepared by reacting hyodeoxycholic acid with ethyl chloroformate at the present of triethylamine.

猪去氧胆酸与氯甲酸乙酯在三乙胺存在下反应生成羟酸－碳酸乙酯混合酐，而后将其与牛磺酸钠进行氨解反应，合成猪磺去氧胆酸。

The mean conˉcentrationsof the total bile acid in the gallbladders were respectively77.53±11.93,51.81±8.12and53.27±7.04in group DM,CH and DMCH,but it was79.28±18.28in group N.Combined bile acids（both glycocholic acid and taurocholic acid）were apparently lessened and the ratio of cholic acid and chenodeoxycholic acid was rised in group DM,CH and DMCH,the concentrationsof cholesterol were respectively5.31±0.81,5.69±2.20and5.12±1.47,but0.86±0.20,in the group N;those of phospholipd were respectively0.35±0.16,0.52±0.18and1.38±0.34,but0.59±0.28,group N.

胆囊胆汁成分分析中，DM组、CH组和DMCH组总胆汁酸分别为77.53±11.93、51.81±8.12和53.27±7.04，N组为79.28±18.28；与N组比较结合胆汁酸减少，其中甘氨胆汁酸盐与牛磺胆汁酸盐均减少；鹅去氧胆酸减少，胆酸/鹅去氧胆酸比值升高；胆汁胆固醇分别为5.31±0.81、5.69.20和5.12±1.47，N组为0.86±0.20；磷脂分别为0.35±0.16、0.52±0.18和1.38±0.34。

Stones were seen in the gallbladder of12/12cases in either group DM and CH,and11/12in the group DMCH.The mean conˉcentrationsof the total bile acid in the gallbladders were respectively77.53±11.93,51.81±8.12and53.27±7.04in group DM,CH and DMCH,but it was79.28±18.28in group N.Combined bile acids（both glycocholic acid and taurocholic acid）were apparently lessened and the ratio of cholic acid and chenodeoxycholic acid was rised in group DM,CH and DMCH,the concentrationsof cholesterol were respectively5.31±0.81,5.69±2.20and5.12±1.47,but0.86±0.20,in the group N;those of phospholipd were respectively0.35±0.16,0.52±0.18and1.38±0.34,but0.59±0.28,group N.

胆囊胆汁成分分析中，DM组、CH组和DMCH组总胆汁酸分别为77.53±11.93、51.81±8.12和53.27±7.04，N组为79.28±18.28；与N组比较结合胆汁酸减少，其中甘氨胆汁酸盐与牛磺胆汁酸盐均减少；鹅去氧胆酸减少，胆酸/鹅去氧胆酸比值升高；胆汁胆固醇分别为5.31±0.81、5.69.20和5.12±1.47，N组为0.86±0.20；磷脂分别为0.35±0.16、0.52±0.18和1.38±0.34。

The alternative method of O-demethylation,methane sulfonic acid/DL-methionine and hydrobromic acid were investigated.

方法在以蒂巴因为原料，经氧化、氢化、酰化、氰化、去氧甲基、水解、N-烯丙基化得到纳洛酮的合成路线中，分别采用甲磺酸/DL-甲硫氨酸和氢溴酸代替三溴化硼进行去氧甲基化和后续水解反应。

We evaluated the photooxidative DNA damage, indicated by the specific content of 8-hydroxy-2'- deoxygaunosine (8-OHdG), in human pterygium. In addition, we analyzed the relationship between the genetic polymorphism of the DNA repair enzyme hOGG1 and the pterygium risk in a Chinese population.

首先，我们尝试以8-氢氧-2'-去氧鸟粪核糖苷( 8-hydroxy-2'- deoxyguanosine， 8-OHdG )为指标，找出眼翳组织中去氧核糖核酸( deoxyribonucleic acid， DNA )所受到的光氧化性损伤之证据。

After six procedures for the synthesis of deoxybenzoins reported recently were studied carefully, we finally invented a new method to prepare polyhydric deoxybenzoins.

二、详细探索了多种去氧安息香合成方法，对于近期文献报道的6种制备工艺进行了跟踪研究，首次在Hoesch反应中引入了含磷或硫的催化剂，进而发明了一种制备多羟基去氧安息香的合成新工艺。

Chenodeoxycholic acid ,cholic acid,ursodeoxycholic acid ,hyodeoxycholic acid,deoxycholic acid,Dehydrocholic acid

熊去氧胆酸，鹅去氧胆酸，猪去氧胆酸，胆酸，去氧胆酸，去氢胆酸，胆酸钠，去氧胆酸钠，猪去氧胆酸钠，猪胆盐，牛胆盐，禽胆盐，猪胆粉，牛胆粉，三号胆盐

Cynanchum Lingtai apricot production in the average weight 65 grams, the brightly-colored fruit, juicy rich, sweet-sour taste, sweet from the nucleolus, when the late Qing Dynasty famous Shaanxi, Gansu provinces, the Qing imperial court Tongzhi tribute for years.

灵台生产的牛心杏平均单果重65克，果实色泽鲜艳，汁多味浓，甜酸适口，离核仁甜，清末时就驰名陕、甘两省，清同治年间曾为朝廷贡品。

Chenopodium album,Solanum nigrum, and Amaranthus retroflexus were very susceptible to the herbicides. Polygonum persicaria and Abutilon theophrasti were relatively less susceptible to the herbicides, and Lycopersicon esculentum was not susceptible to it. The relationship between reduction rates of weed biomass and PPM values of weed leaves 2,4, and 6 days after treatment was established.

供试的6种杂草对该混剂的敏感性存在显著差异：红心藜Chenopodium album、龙葵Solanum nigrum和反枝苋Amaranthus retroflexus对该混剂最敏感，ED90值分别为47.65、71.67和29.17g/hm2；春蓼Polygonum persicaria和苘麻Abutilon theophrasti敏感，ED90值分别为96.91、114.20g/hm2；而番茄不敏感。