初步

Furthermore, preliminary work also performed to examine whether PI3K/AKT signal transduction pathway was activated in the process of refractory leukemia development. Materials and methods An immortalized human bone marrow stromal cell line, HS-5, was introduced to establish a bi-phase culture system for the cultivation of B-lineage precursor leukemia cells. ELISA and RT-PCR were used to investigate the expression of VEGF and its receptors in the leukemia cell lines and primary childhood leukemia cells in different treated groups. Flow cytometory method and immunofluorescent staining were employed to examine the apoptosis signals both in the VP16 treated and untreated leukemia cells. Western blot was utilized to explore the PI3K/AKT activated status in the drug induced or uninduced leukemia cells and lymphocytes from healthy donors.

材料和方法使用来源于人类骨髓基质细胞的细胞株HS-5作为滋养层细胞进行急性淋巴细胞性白血病细胞的体外培养，通过细胞生物学和免疫学方法评估培养体系并鉴定出难治性白血病细胞克隆；以ELISA和RT-PCR方法检测急性白血病细胞株和患儿白血病细胞VEGF及其受体的表达，了解不同治疗阶段VEGF及其受体的表达状况，并结合临床指标进行分析，明确VEGF及其受体在白血病发生过程中的作用；流式细胞仪和免疫荧光染色法对正常健康儿童、初发白血病患儿、复发白血病患儿及缓解后患儿进行凋亡因子检测和分析，初步阐明难治性白血病抗凋亡形成的原因；蛋白印记分析检测PI3K/AKT信号传导通路在健康儿童、初发白血病和复发白血病患儿的表达，初步了解难治性白血病形成的分子生物学机制。

This paper has mainly analysedvertical oblique flow circulating pump operation properties. Through monistic flowdesign theory, carried out preliminarily design for impeller, and completedthree-dimensional model analysis through CAD software. With the aid of CFD-FLUENTsoftware platform, have carried out value for flowing imitation in pump, the SIMPLECmethod on unstructural grid has realized pressure the couple of speed, which verified theresult of preliminary design.

本文主要分析了立式斜流循环水泵运行特性，通过一元流设计理论，对叶轮进行初步设计，并通过 CAD 软件进行立体三维模型分析，借助 CFD-FLUENT 软件平台，对水泵内流场进行了数值模拟，利用非结构网格上的 SIMPLEC 方法实现压力-速度的耦合，对初步设计进行计算结果的验证。

With complex system and behavioural finance theory, a multi-agent trade market model is primarily built. Furthermore a relevant information auto- retrieval platform based on Internet, a background-based distributed computing platform for apperceiving agent and a simulated real-time trade system are primarily realized. Both experimental results and theoretical analyse show that effective market hypothesis as support for capital market and capital asset pricing theory (Nobel Prize in economics in 1990) are defective. These results also verify the feature of GARCH model (Nobel Prize in economics in 2003). Moreover, a quantitative analytic way to behavioural capital asset pricing theory (Nobel Prize in economics in 2002) in behavioural finance is presented.

结合复杂系统理论和行为金融学理论，初步建立了一个主体交易市场模型，一个基于互联网的信息自动获取平台、一个基于后台分布式主体感知计算平台和一个模拟实时交易的原型系统，在此基础上，通过大量的数据计算、实验和理论分析，指出了资本市场的理论支柱之一的有效市场假设理论和资本资产定价理论（1990年诺贝尔经济学奖）存在的缺陷，验证了GARCH模型（2003年诺贝尔经济学奖）的特征，提供了行为金融学中行为资产定价理论（2002年诺贝尔经济学奖）的初步量化分析结果。

The genetic behavior of these QTLs were investigated accordingto the performance of backcrosses.

5对以IR24为遗传背景的一套籼型渗入系进行了三地两年的详细考察，初步确认了各渗入系中所携带的渗入片段对抽穗期、株高、穗数、实粒数、总粒数、千粒重、单株重和结实率等性状的影响，并初步定位了11个重要农艺性状和产量性状QTLs，估算了这些QTLs的遗传效应，并在回交和测交中进一步确定了这些QTLs的遗传行为，讨论了渗入系在QTL精细定位与杂种优势机理研究中的应用。

The second part is a generalization about developing of the animal law. Laboratory animal law. A new trend of legislating on this issue is put forward in the third part ,. The last part do some primary studies on the newly emending wild animal law.

第二部分对动物法的发展做了归纳，第三部分在对实验动物的情况和实验动物法做了介绍与初步研究，最后对野生动物保护法的修订这个中国动物法的重要方面做了初步的探索。

Once a prima facie showing of no specific and substantial credible utility has been properly established, the applicant bears the burden of rebutting it. The applicant can do this by amending the claims, by providing reasoning or arguments, or by providing evidence in the form of a declaration under 37 CFR 1.132 or a patent or a printed publication that rebuts the basis or logic of the prima facie showing.

一旦初步认定无具体实在的可信的实用性已经恰当的确立起来，申请人就要承担推翻它的责任，申请人可以通过修改权利要求、通过提供驳斥初步认定的根据或逻辑的证据或论据，或者提供under37CFR1.132 的声明形式的证据或者专利或者印刷出版物来做到这一点。

Upon proof being made, at any hearing on a complaint under this section, that there has been discrimination in price or services or facilities furnished, the burden of rebutting the prima-facie case thus made by showing justification shall be upon the person charged with a violation of this section, and unless justification shall be affirmatively shown, the Commission is authorized to issue an order terminating the discrimination: Provided, however, That nothing herein contained shall prevent a seller rebutting the prima-facie case thus made by showing that his lower price or the furnishing of services or facilities to any purchaser or purchasers was made in good faith to meet an equally low price of a competitor, or the services or facilities furnished by a competitor.

在对依据本节提起的价格歧视诉状或已完成的劳务、设施歧视诉状审理中，根据歧视的公正性证据对初步立案进行辩驳的责任，在被诉违反本节的一方，除非歧视的公正性得以充分说明，否则，将授权委员会发布中止歧视令。本规定并不限制卖者通过证明，他的低价或劳务及设施的提供是以良好信誉，平等地同竞争者的低价，或由竞争者提供的劳务、设施相适应，来对初步立案加以辩驳。

Finally, the virtual scene was reedited in a VR software, producing the eventual interactive virtual reality file which could be executed directly. Results: A considerable number of digital 3D models of frequently used implant systems were successfully constructed, initially completing the construction of model base for virtual reality in dental implantology education.

结果：制作完成了部分常用口腔种植系统的相关三维模型，初步建立起了口腔种植修复学教学用虚拟现实的三维模型素材库，初步搭建了1例典型的口腔种植修复临床治疗场景，编辑生成了可直接操作的三维虚拟现实课件。

Schematizing the southern Yellow sea as an constant water depth and semi-enclosed rectangular bay, the evolution trends of tidal amphidromic system of M2and variation features of coast tidal range are analyzed primary under the condition of 3 and 5 meter rise of sea level respectively.

将南黄海概化为一等深矩形海域，初步研究了在海平面上升 3m 和 5m 条件下该海域旋转潮波系统的演化趋势，继而分析了沿岸潮差变化特征。初步分析研；应用海湾和半封闭矩形海域改进的 Taylor 问题的解研究海平面上升对 M2 分潮旋转潮波系统及沿岸潮差的变化。

Schematizing the southern Yellow sea as an constant water depth and semi-enclosed rectangular bay, the evolution trends of tidal amphidromic system of M2and variation features of coast tidal range are analyzed primary under the condition of 3 and 5 meter rise of sea level respectively.

将南黄海概化为一等深矩形海域，初步研究了在海平面上升 3m 和 5m 条件下该海域旋转潮波系统的演化趋势，继而分析了沿岸潮差变化特征。初步分析研究表明：随着海平面上升，该海域 M2 分潮的无潮点有向东南方向偏移的趋势，受此影响，沿。。。应用海湾和半封闭矩形海域改进的 Taylor 问题的解研究海平面上升对 M2 分潮旋转潮波系统及沿岸潮差的变化。

Means the parent directory, so this command means to execute "toolchain.sh," which is in the current directory.

代表父目录，所以这个命令就是执行当前目录下的"toolchain.sh"。

Yes,In fact,I'm on our city ream.

是的。事实上我是我们市队的。