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Further investigation will potentially provide the practical technologies for the diagnosis of human acrosome reaction deficiency

孕酮具有促进人精子受透明带诱导顶体反应的作用;小鼠透明带溶解液具有诱导人精子产生顶体反应的效果并确定了mZPS诱导人精子顶体反应的量效关系,为建立人顶体反应缺陷症的实用诊断技术提供基础。

Methods Animal inflammatory models were established by injection of dimethylbenzene for mice ear swelling, carrageenin for rat footpad, cotton pellet wool for rat granuloma respectively. The content of prostaglandin E2(PGE2) and leukotriene B4(LTB4) from peritoneal macrophages were measured by RIA and RP-HPLC respectively.

采用二甲苯诱导的小鼠耳肿胀、角叉菜胶诱导的大鼠足肿胀、棉球诱导的大鼠肉芽肿模型观察TFC的抗炎作用;分别采用放射免疫法和反相高效液相色谱法检测TFC对大鼠腹腔巨噬细胞产生前列腺素E2(PGE2)和白三烯B4(LTB4)的影响。

Results TFC significantly inhibited mice ear swelling and rat palm swelling and rat cotton pellet granuloma. It also showed that the content of PGE2 and LTB4 from PMФ were inhibited by TFC in dose-dependent manner.

结果 TFC对二甲苯诱导的小鼠耳肿胀、角叉菜胶诱导的大鼠足爪肿胀、棉球诱导的大鼠肉芽肿具有抑制作用;TFC在0.05~50mn/L范围内能够浓度依赖性地抑制PMФ中PGE2和LTB4的产生。

Changdong" showed a noticeable enhancive effect when it was co-administrated with other anti-tumor agents or when it was co-applied with radiotherapy. The action mechanism study showed that an apparent cytotoxic effect of "Changdong" on ten tumor strains in vitro with a quantity-effect relationship was observed. Immunity experiment showed that "Changdong" could induce proliferation of spleen lymphocyte in mice bearing tumor and could improve NK cell" s activity, whereas has no impact on IL-2" s reproduction. It was also noticed that "Changdong" could induce human liver cancer QGY" s apoptosis in vitro, and it happened mainly on G0-G1 phase.

结果:"长动"对小鼠移植瘤模型和人体肿瘤裸鼠异种移植均有明显抑制作用,量效关系明显:"长动"与放疗和化疗分别联合应用有明显的增效作用:作用机制研究结果:细胞毒性试验研究表明"长动"在体外对10株肿瘤细胞有明显的细胞毒性作用,量效关系明显;免疫学试验表明"长动"可以诱导荷瘤小鼠的脾淋巴细胞增殖,增强NK细胞的活性,对IL-2的产生无明显影响;"长动"在体外可明显诱导人体肝癌QGY细胞凋亡,使细胞阻滞于G0-G1期。

Hypoxia induces the resistance of tumor cells[4];and the heterogeny of solid tumors result in the appearance of subpopulations of differentproliferative potency in the same tumor tissue, so that the target cells sensitive to cell cyclespecific drug are reduced.

目前有研究认为:实体瘤部分细胞缺氧和肿瘤组织的异质性可能是导致肿瘤对放疗和化疗产生耐受的主要原因之一,缺氧可以诱导肿瘤细胞对放疗和化疗的耐受性[4],实体肿瘤的异质性可使同一瘤组织内具有不同增殖潜能的癌细胞亚群存在,导致细胞周期特异性化疗药物作用的靶细胞减少。

Based on these results, it is suggested that theinhibition of NO and prostaglandin E2 over-production throughsuppressing iNOS and COX-2 induction and attenuation of TNF- formation and neutrophil infiltration into inflammatory sitesby C-PC may contribute, at least in part, to its antihyperalgesicactivity.

这些研究结果提示, C-PC 的镇痛活性至少部分是通过抑制炎症部位 iNOS 和 COX-2的诱导作用和减少 TNF-的形成及中性粒细胞的浸润来抑制 NO 和前列腺素 E2的过多生成而产生。

This has been discussed before and demonstrated in previous studies but for e-antigen and in the surface antigen the hepatologist considers that they are very important in inducing the immune tolerance because this kind of antigen can induce the impairment of dendritic cells and also can induce the generation of regulatory T cells.

HBeAg在诱导免疫耐受方面的作用已经被讨论过并在以前的研究中证明过,现在肝病学家认为HBsAg在诱导免疫耐受方面也有重要作用,因为这类抗原能诱导树突状细胞的损伤,并能诱导产生调节性T细胞。

A series of consequent negative influences are mainly as follows. In terms of the loss of natural ecology, the traditional technical innovation cajoles people into inappropriate consumption, causes the malformed development of techniques, results in the ecological loss of technical rationality and functions as an amplifier to technical dissimilation. In terms of ecological loss of society, due to ecological loss of themselves, traditional activities of technical innovation will produce bad effect on people's value views, on much loss of intellectuals in undeveloped countries,on social economy,on political and economic orders in the world and on polarization between the rich and the poor.

由此而带来一系列的负面影响,这集中表现在:在自然生态缺失方面,传统技术创新诱导了人们的不正当消费、导致了技术的畸形发展、造成了技术理性的生态缺失以及对技术异化起到了放大器的作用;在社会生态缺失方面,由于自身的生态缺失,传统技术创新活动对人类的价值观念、对落后国家的人才流失、对社会经济、对全球政治经济秩序以及对贫富两极分化亦会产生一些不利的影响。

Vascular effects of thrombin: involvement of NOR-1 in thrombin-induced mitogenic stimulus in vascular cells.

凝血酶对血管的作用:与在凝血酶诱导下的血管细胞有丝分裂所产生的 NOR-1有关

Properties of the reaction medium may be able to affect the function of organic macromolecular additives to some extent.

反应介质的性质能对有机大分子添加剂的诱导作用产生一定的影响。

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