临床

Objective To draw up prepared craft of the compound viaminate cream,to investigate the stability and clinical curative effects of that product.Methods The adoption emulsifies to emulsify the function system fully the milk cream, and carry on the quantity control to the milk cream and experiment and centrifugation test,drug stimulate over a long period of time to experiment and the clinical curative effect observation.

目的 制定复方维胺脂乳膏的制备工艺，考察该制剂的稳定性和临床疗效方法采用乳化剂的乳化作用制备乳膏，并对乳膏进行质量控制、长期试验和离心实验、药物刺激性试验及临床疗效观察。

The team developed a siRNA product that specifically blocks the transcription of the gene that codes for IL-8, thereby blocking production of this protein, and encases it in a liposome delivery system. In mouse studies, this product showed activity against 2 ovarian cancer cell lines, both when used alone and when used in combination with docetaxel. In addition, the mouse studies revealed that the product was decreasing tumor growth through anti-angiogenic mechanisms — the treated tumors showed a lower microvessel density, the researchers report. This product was "highly effective in our preclinical studies and may merit clinical development," they write. However, they also caution that the cell lines used to create the mouse models might not accurately reflect the heterogeneity seen in human tumors.

该团队发展一种siRNA产品，特别阻断IL-8的基因转译密码，因此阻断此一蛋白质之产生，且将它包入一个微脂粒传递系统；在老鼠研究中，不论单独使用或者和docetaxel并用，此产品显示对两种卵巢癌细胞线有活性；此外，老鼠研究发现此产品可透过抗血管新生机转减少肿瘤生长—报告指出，治疗的肿瘤显示较少的微血管密度，此产品在我们的临床前研究中相当有效，值得临床发展；不过，他们也表示，所用的老鼠研究中的细胞线可能无法精准反应人类肿瘤的异质性。

The team developed a siRNA product that specifically blocks the transcription of the gene that codes for IL-8, thereby blocking production of this protein, and encases it in a liposome delivery system. In mouse studies, this product showed activity against 2 ovarian cancer cell lines, both when used alone and when used in combination with docetaxel. In addition, the mouse studies revealed that the product was decreasing tumor growth through anti-angiogenic mechanisms — the treated tumors showed a lower microvessel density, the researchers report. This product was \"highly effective in our preclinical studies and may merit clinical development,\" they write. However, they also caution that the cell lines used to create the mouse models might not accurately reflect the heterogeneity seen in human tumors.

该团队发展一种siRNA產品，特别阻断IL-8的基因转译密码，因此阻断此一蛋白质之產生，且将它包入一个微脂粒传递系统；在老鼠研究中，不论单独使用或者和docetaxel併用，此產品显示对两种卵巢癌细胞线有活性；此外，老鼠研究发现此產品可透过抗血管新生机转减少肿瘤生长—报告指出，治疗的肿瘤显示较少的微血管密度，此產品在我们的临床前研究中相当有效，值得临床发展；不过，他们也表示，所用的老鼠研究中的细胞线可能无法精準反应人类肿瘤的异质性。

Addressing this need, Clinical Manual of Trigeminal Neuralgia and Facial Pain familiarizes clinicians with the diagnosis of trigeminal neuralgia and also makes them aware of the newer treatments available.

为满足这一需要，三叉神经痛的临床及面部疼痛手册familiarizes与三叉神经痛临床诊断，也使他们较新的治疗方法可以知道。

Improving the effectiveness of interventions through improved clinical and management skills, design of basic preventive and clinical packages, treatment protocols, technology review panels, limited drug formularies, training, and research on the efficacy and cost of different interventions.

改进干预措施有效性，通过改进临床和管理技能，设计的基本预防和临床套餐，治疗方案，技术审查小组，有限的药物处方，培训和研究的疗效和成本的不同的干预措施。

Granulomas can result in specific manifestations, and obscure the nature of lymphomas, hence, cautions should be given to clinical and histological diagnosis of cutaneous granulomas.

肉芽肿形成可能是造成某些淋巴瘤特殊临床表现的原因，也容易掩盖淋巴瘤的真实面目，在临床和组织学诊断上需谨慎。

objective to evaluate the effect of urapidil on the treatment of congestive heart failure.methods thirty patients with congestive heart failure were included in the study.urapidil was given by intravenously guttae at 50mg 5~7days.results systolic blood pressure and l dbp were decreased and sao2 and cardiac output were increased after treatment.conclusion intravenous urapidil produces acute hemodynamic benefit in patients with congestive heart failure.

目的 观察利喜定治疗充血性心力衰竭的临床疗效。方法 30例充血性心力衰竭患者，先以利喜定12.5 mg稀释于20 ml生理盐水中于3~5 min内静脉注射，继以利喜定50 mg、多巴胺20mg加于250 ml液体中静滴，每日1次，滴速为利喜定100~400 μg/min，连用5~7 d。结果利喜定可显著降低收缩压、舒张压，升高血氧饱和度、左室射血分数，不引起反射性心率增快。结论利喜定治疗各种原因引起的充血性心力衰竭，可有效改善患者的临床症状和血流动力学指标。

Results CT and HRCT had more sensitivity and specificity than X-ray chest film.There were more image manifestations in HRCT such as grand grass,net,line,nodular,honeycombing,bronchiectasis,honeycombing cyst,peribronchovascular interstitial thickening and irregularity.There were significant difference between them （P.05）.These patients who were suspected IIP had better control and remission after being treated with hormone and immuno-suppressive drug.

结果 胸部CT在诊断方面比常规胸片有较大的优越性，HRCT则有更高的敏感性和特异性，HRCT表现出磨玻璃影、网状、线条、小结节、蜂窝影，支气管扩张、细支气管扩张、支气管壁和血管壁增厚及不规则等征象，12例临床疑诊为间质性肺炎的患者，经胸部HRCT诊断的12例，而胸部平片诊断的仅有2例，二者比较差异有显著性（P.05），HRCT疑诊的IIP患者，经临床激素及免疫抑制剂治疗，病情均得到控制或缓解。

Clinical manifestations of DILI is changeable and medical workers should attach great importance to DILI, learn more about the clinical efficacy of drug characteristics and susceptibility factors inflecting liver damage, and take timely measures to deal with this disease once it is discovered.

急性药物性肝损伤的临床表现多变，医务工作者对急性药物性肝损伤应予以高度重视，详细了解药物的临床药效特点和肝损伤的易感因素，一旦发病，及时采取措施处理。

Clinical manifestations of DILI is changeable and medical workers should attach great importance to DILI, learn more about the clinical efficacy of drug characteristics and susceptibility factors inflecting liver damage, and take timely measures to deal with this disease once it is discovered.

急性药物性肝损伤的临床表现变，医务工作者对急性药物性肝损伤应予以高度重视，详细了解药物的临床药效特点和肝损伤的易感因素，旦发病，及时采取措施处理。

Cynanchum Lingtai apricot production in the average weight 65 grams, the brightly-colored fruit, juicy rich, sweet-sour taste, sweet from the nucleolus, when the late Qing Dynasty famous Shaanxi, Gansu provinces, the Qing imperial court Tongzhi tribute for years.

灵台生产的牛心杏平均单果重65克，果实色泽鲜艳，汁多味浓，甜酸适口，离核仁甜，清末时就驰名陕、甘两省，清同治年间曾为朝廷贡品。

Chenopodium album,Solanum nigrum, and Amaranthus retroflexus were very susceptible to the herbicides. Polygonum persicaria and Abutilon theophrasti were relatively less susceptible to the herbicides, and Lycopersicon esculentum was not susceptible to it. The relationship between reduction rates of weed biomass and PPM values of weed leaves 2,4, and 6 days after treatment was established.

供试的6种杂草对该混剂的敏感性存在显著差异：红心藜Chenopodium album、龙葵Solanum nigrum和反枝苋Amaranthus retroflexus对该混剂最敏感，ED90值分别为47.65、71.67和29.17g/hm2；春蓼Polygonum persicaria和苘麻Abutilon theophrasti敏感，ED90值分别为96.91、114.20g/hm2；而番茄不敏感。