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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle，CP)和两个19S调节颗粒(regulatory particle，RP)组成的ATP(adenosine-triphosphate，ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心，它是由4个圆环堆叠形成的桶状复合物，其中两侧外环每个环是由α_1-α_7亚基组成，两个内环每个环是由β_1-β_7亚基组成，4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔，其内壁为催化活性位点所在地；外侧α环中心的孔道是底物到达催化中心空腔的通道，一般被α亚基上的N末端所封闭，阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

Across 5,000-odd miles and two weeks, Barrowman and Gill each tell me their love story, and like two guilty men in an interrogation, their fairy-tale versions match up almost perfectly.

JB和Scott分别接受的采访，像两个受审的犯人一样，但他们对自己如童话般邂逅的描述如出一辙

Starting at two Sunday afternoon and grinding until four AM Monday, Gabe "The Babe" Owen and Chris "Dante" Bartram set the stakes at $7,000 for a twelve-ahead set in 10-ball, the Columbus, OH, road player getting the last two from 2005 US Open 9-Ball champ Owen.

开始，在两个星期日下午和研磨，直到4时，周一，盖"贝贝"欧文和克里斯"但丁" bartram设置的利害关系在$ 7000 ，为1 12 -未来订定在10球，哥伦布，哦，道选手获得最后二，从2005年美国网球公开赛9球锦标赛欧文。

Therefore, the basie feature of Zhuangzhou's philosophy is the two-fold-in-one of the living outlook and ecological Outlook,such feature is mainly embodied in : expressing man's free nature by use of large ecological Outlook; the crux of such large ecological outlook is the protection and exploration of man's spirit ecology. This two...

因此，庄子哲学的根本特点便是生存观与生态观的二重合一，这种二重合一主要体现在：用大生态观言说人类的自由本性；这种大生态观的实质是对人类精神生态的保护与开掘；庄子哲学生存观与生态观的二重合一突出体现在《庄子》一书的叙事方式上。

The times given in the tables are accurate to within two or three hours for 25 to 5 BCE, and one or two hours for 4 BCE to 38 CE.

时代给予在该表是准确的，以两个或三个小时，为25日至5 bce ，和一个或两个小时为4 bce至38行政长官。

At least two separate inhibitory actions on 5-HT3A receptors could be identified for propofol, whereas the enhancing action seen for the two related smaller phenol derivatives could no longer be detected. 5-HT-dependent and 5-HT-independent interactions could be distinguished for all three drugs.

异丙酚被证实对5-HT3A 受体至少有两种相互独立的作用，而在两种相关的较小分子的酚类衍生物中所看到的增强作用则不能被检测到。5-HT 依赖和5-HT 非依赖两种相互作用因为这三种药物而著称。

If, however, you move the whole body to a time zone which is four hours different, the two clocks will be out of step, like two alarm clocks which are normally set together, but which have been reset a few hours apart.

然而，如果你将整个身体转移到相差四个小时的时区，这两个小时钟就不协调了。就像两个闹钟通常一起设置，但被重新设置时相差了好几个小时。

If, however, you move the whole body to a time zone which is four h ours different, the two clocks will be out of step, like two alarm clock s which are normally set together, but which have been reset a few hours apart.

然而如果你把整个身体移到一个时差4个小时的时区，两个时钟就不再同步，正像两个闹钟通常被一起定时，但现在定时相差几个小时，两个闹钟通常同时报时，但现在则不同时间报时。

Large numbers of UN staff were reported to be missing, as well as two American and two Australian citizens.

许多联合国的工作人员被报失踪，以及两名美国和澳大利亚公民。

The program can be tied up for two documents, and synchronous and asynchronous two means of implementation.

该程序可以将两个文件进行捆绑，并有同步、异步两种执行方式。

What are your goals and strategies for growth?

你的成长目标和策略是什么？

And unto the angel of the church in Sardis write; These things saith he that hath the seven irits of God, and the seven star I know thy works, that thou hast a name that thou livest, and art dead.

3：1 你要写信给撒狄教会的使者，说，那有神的七灵和七星的，说，我知道你的行为，按名你是活的，其实是死的。