查询词典 tolbutamide

The substrates for measuring the activity of individual CYP in vitro included phenacetin, tolbutamide, debrisoquine, and omeprazole. RESULTS: Ther...

结果：CYP1A2、2C9及3A4的含量和活性具有很大的个体间变异，另外CYP2D6的活性在各样本间也有很大差异；CYP3A4(32％)是中国人肝微粒体中含量最丰富的CYP，CYP2C9(19％)和CYP1A2(16％)的含量也很可观；除了CYP1A2的含量和活性具有一定的种族和性别差异外，未发现其它CYP具有种族和性别差异；CYP1A2、2C9和3A4的酶蛋白含量分别和它们的活性具有很好的相关性。

Determination of tolbutamide in human plasma by reversed phase high-performance liquid chromatography

目的：建立反相高效液相色谱法测定人血浆中甲磺丁脲含量的方法。

In this study, tolbutamide was used as a model drug and three different approaches of crystallization methods including cooling crystallization, salting out crystallization, and melting crystallization were used to search for various polymorphs.

文中采用Tolbutamide为模式药物以及三种不同的结晶方法，包括冷却结晶、盐析结晶与熔融结晶以寻找各种多晶型。

Fig. 3.Effects of ATP, tolbutamide and diazoxide on KATP channel.

但通过分析通道的动力学特性可见(表1)，负钳制电位时，通道的开放和关闭时间常数的长成分均较正钳制电位时的短，并且关闭时间常数的短成分在总关闭时间中所占的比例也大于正钳制电位时的。

Sulphonyluren tolbutamide (1 mmol/L), a specific KATP channel blocker, added to the bath completely suppressed the channel activity, while diazoxide (1 mmol/L), a KATP channel opener, had no apparent effect.

KATP通道的特异性阻断剂tolbutamide (甲糖宁， 1 mmol/L)可完全阻断通道的活动，而KATP通道开放剂diazoxide (二氮嗪， 1 mmol/L)则不增强通道的活动。

The experiments showed a significant increase in Bax mRNA levels (P.01) in neurons cultured at severe hypoxia condition compared with those cultured at normoxia. In hypoxia groups, tolbutamide increased Bax mRNA expression (P.05), while diazoxide reduced it (n=5 for each).

缺氧+二氮嗪组中基因Bax的mRNA表达水平与单纯缺氧组相比下降(P.01)，缺氧＋甲苯磺丁脲组中基因Bax的mRNA表达水平相对于单纯缺氧组也有提高(P.05)。

Sulfonylurea tolbutamide (1mmol/L), a specific K〓 channel blocker, added to the bath completely suppressed the channel activity while diazoxide (1mmol/L), a K〓 channel opener, had no apparent effect on the current.

通道的特异性阻断剂tolbutamide（甲糖宁，1mmol/L）可完全阻断通道的活动，而〓通道开放剂diazoxide（二氮嗪，1mmol/L）则不增强通道的活动。

Methods: Glipizide gliclazide glyburide glimepiride gliquidone repaglinide nateglinide pioglitazone rosiglitazone metformin phenformin and tolbutamide added in the blank ground samples were extracted with 80% methanol and were separated from an ACQUITY UPLC DBH C18 column with a gradient mobile phase of acetonitrile - 0.2 % formic acid water solution. A tandem quadrupole mass spectrometer equipped with electrospray ionization source was used in positive ion mode multiple reaction monitoring was performed to quantify above mentioned compounds.

被添加在中成药制剂及其包装物中的二甲双胍、苯乙双胍、罗格列酮、吡格列酮、格列吡嗫娶瑞格列奈、甲苯磺丁脲、格列齐特、格列苯脲、那格列奈、格列美脲、格列喹酮等西药成分用80%甲醇提取，以乙腈- 0.2%甲酸水溶液为流动相梯度洗脱，在ACQUITY UPLC DBH C18色谱柱上分离，串联四级杆质谱检测，MRM方式采集并定量。

Generic names: acetohexamide, chlorpropamide, glimepiride, glipizide, glyburide, tolazamide, tolbutamide.

商品名：醋磺已#、氯磺丙#、格列美#、格列##、格列本#、甲磺丁#、氯磺丙#和妥拉磺

Methods Seven probe drugs were incubated with or without methyl protodioscin respectively in human microsomes. The specific substrates used in this study were caffeine (CYP1A2), dextromethorphan (CYP2D6), tolbutamide (CYP2C9),-mephenytoin (CYP2C19), chlorzoxazone (CYP2E1), coumarin (CYP2A6) and midazolam (CYP3A4). The concentrations of the substrate metabolites (paraxanthine, dextrorphan, 4-hydroxytolbutamide, 4-hydroxymephenytoin, 6-hydroxychlor-zoxazone, 7-hydroxycoumarin and 1-hydroxymidazolam) were determined by HPLC and LC-MS/MS. Results MPD 1-10 μmolL^(-1 had no significant inhibition on the activities of the seven cytochrome P450 enzymes.

将MPD和CYP450酶7种亚型的特异性探针底物咖啡因(CYP1A2)、右美沙芬(CYP2D6)、甲苯磺丁脲(CYP2C9)、s-美芬妥因(CYP2C19)、氯唑沙宗(CYP2E1)、香豆素(CYP2A6)及咪达唑仑(CYP3A4)与人肝微粒体进行孵化反应，采用HPLC和LC-MS/MS法测定对应的7种代谢产物（1，7-二甲基黄嘌呤、去甲右美沙芬、4-羟基甲苯磺丁脲、4-羟基美芬妥因、6-羟基氯唑沙宗、7-羟基香豆素和1-羟基咪达唑仑）的浓度，通过与对照组比较，确定MPD对以上7种酶活性的影响。

On closer examination, though, this is not a vote for multilateralism but just the opposite.

仔细审视后我们发现，这并非是对多边主义投出的赞成票，而是恰好相反。

Uncovering their weak spots, so I can defeat them.

揭露出他们的弱点，这样我就可以打败他们了。