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In the experiment, an approach was made to the cause of DRP and the mechanism of it's prevention and treatmend by acupuncture. The experimental results indicated that in rat with diabetes,(1) plasma TXB2 and the ratio of TXB2 to 6-keto-PGF1α increased obviously, suggesting hyperfunction of platelet and injury to endothelial function, which tend to result in thrombosis;(2) erythrocytic filtration index increased remarkably, suggesting erythrocytic transforming and oxygen carring hypofunction, which is one of the factors leading to retinal anoxia;(3) hyperglycemia persisted, which is related to the thickening of basilar membrane of and the decrease of mural cell of retinal blood vessels;(4) serum growth hormone rose notably, which is not only one of the important factors causing basilar membrane thickening but also promotes the synthesis or Von Willebrand Factor that participates in a tendency to thrombosis.

本实验对糖尿病性视网膜病变（Diabetic Retinopathy，DRP）的成因以及针刺防治DRP的作用机理进行了探讨，实验结果表明：糖尿病大鼠（1）血浆TXB2及TXB2/6-ket0-PGF1α比值均显著升高，提示其血小板机能亢进，内皮细胞功能损伤，具有血栓形成倾向；（2）红细胞滤过指数（Filtration Index，IF）显著增高，提示其红细胞变形能力低下，携氧运行功能降低，是造成视网膜缺氧状态的因素之一；（3）呈持续高血糖状态，与视网膜血管基底膜增厚及管壁细胞减少有关；（4）血清生长激素（Growth Hormone，GH）水平明显升高，既是导致基底膜增厚的重要因素之一，又促进VWF合成，参与血栓形成倾向。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降，而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高；但是，OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异；⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明：①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异，并以肝组织中的差异氨基酸数量为最多，包括各种生酮和生糖氨基酸水平在OP组的升高，说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一；②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸，说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异；③长期高脂饮食喂养后，动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异，这些菌群上的差别可能在动物体重增长的调节上产生影响；④与OR动物相比，OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

Senator Trent Lott apologized for suggesting that the country would have averted many problems if onetime segregationist Strom Thurmond had won the 1948 presidential race. Vicente Fox, the president of Mexico, apologized for saying that Mexicans were willing to take jobs in the United States "that not even blacks want to do." Evange list Pat Robertson apologized for saying that the United States should kill Venezuela's president, Hugo Chavez, and for suggesting that the stroke suffered by Israeli prime minister Ariel Sharon was divine retribution for "dividing God's land."

共和党参议员Trent Lott为曾说过如果1948年总统选举中当时是参议员的Strom Thurmond获胜美国将不会出现一系列的问题而道歉；墨西哥总统Vicente Fox，为曾说过墨西哥人愿意干"那些甚至连黑人都不愿意做的"工作而道歉； Evange list Pat Robertson 为曾说美国应当处死委内瑞拉总统 Hugo Chavez并暗示以色列首相Ariel Sharon遭受心脏病打击是因为他"分裂上天的土地。"

The crystallization temperature and pressure of clinopyroxene phenocrysts from the ankaramite and basalt were estimated on the basis of the clinopyroxene-melt equilibrium principle: 1345～1366℃ and 1.75～2.05Gpa for ankaramite, with average geothermal gradient of 20-24℃/km, suggesting anomalous heat or geothermal gradient in this region may be one of the key reasons to produce the porphyry copper deposits in the region. In contrast, those in the basalts fomed under a relatively low crystallization temperature (1129～1191℃), and the pressure (1.19～1.60Gpa) and depth (39～53km), suggesting that the basalt formed under a condition of lower temperature and pressure.

根据单斜辉石-熔体平衡原理计算了富辉橄玄岩和玄武岩中斑晶相辉石形成的温度和压力，前者变化范围主要集中在1345～1366℃和1.75～2.05GPa，其深度相当于58－67km，平均的地温梯度大约20～24℃/km，说明该区具有异常的热或地温梯度，这可能是导致本区斑岩铜矿形成的主要原因之一；后者的温度和压力都相对较低，分别为1129～1191℃和1.19～1.60Gpa，而相应的深度为39～53km，暗示着玄武岩是在相对低温低压的环境中形成的演化岩浆。

Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.

结果显示：1BP刺激细胞可促进c-Jun活化，并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性，均可明显抑制BP诱导的c-Jun活化，但阻断p38活性对BP引起的c-Jun活化无明显影响，提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化，并降低磷酸化ERK的表达水平，但对磷酸化JNK的表达水平无明显影响，说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加，并同时诱导Akt和ERK的磷酸化水平的升高，表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况，发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加，提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化，降低磷酸化Rb以及E2F1蛋白表达水平，表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高，可见c-Jun也参与调控BP诱导的p53/p21通路活化。

Omental GISTs unattached to gastrointestinal tract often resemble gastric GISTs suggesting that they may be gastric GISTs directly extending or parasitically attached into the omentum, whereas multiple omental GISTs more often resemble small intestinal GISTs suggesting that they may be metastatic or detached from this source.

不与胃肠道粘连的网膜GISTs常类似胃GIST，它们有可能是胃GISTs的直接延伸，或是寄生于网膜中（只不过最初与胃连接的地方已不存在）。

A relative low lake level between 8660～6010 cal.yr BPwas reflected by the clayey silt sediment with the median size less than 25μam and the sandcontent less than 4%,and the Pediastrum concentration was normally low.Between 6010 and2250 cal.yr BP,the median size and sand content increased greatly,and the Pediastrumconcentration raised sharply,suggesting a relative low lake level.After 2250 cal.yr BP,boththe median size and the Pediastrum abundance abruptly declined,suggesting the lake returnedto high level and the climate changed to humid.

UG04孔硅藻记录重建的湖泊水位变化基本上支持孢粉重建的古植被和古气候：8660～7230 cal.yr BP硅藻组合以浮游类主导，浮游／底栖比达40以上，指示水位较高，气候略湿润；7230～2330 cal.yr BP浮游类硅藻丰度和浮游／底栖比降低，湖泊处于低水位，气候干旱；2330～930 cal.yr BP浮游类硅藻丰度和浮游／底栖比增加，湖泊水位升高，气候湿润。

From 6860 to 3170 cal.yr BP,semi-desert steppeexpanded,regional montane forest steppe retreated,suggesting a prolonged warm and dryclimate.Between 3170 and 2340 cal.yr BP,regional forest steppe expanded whereassemi-desert steppe retreated,indicating the climate became cool and wet gradually and thehumidity reached the maximum at the end of this stage.During 2340～1600 cal.yr BP,Poaceae steppe dominated whereas wetland meadow expanded and the montane forest stepperetreated,suggesting a cool and wet climate prevailed,wormwood grass steppe prevailed andthe climatic instability increased after 1600 cal.a BEThe climate and environmental reconstructions by pollen were supported by the diatomrecords.A relative high lake level and moister climate prevailed between 8660 and 7230 cal.yr BP as inferred by the dominance of planktonic diatom genera and high planktonic/benthicratio (〉40).low lake level and dry climate sustained during 7230～2330 cal.yr BP assuggested by the low abundance of planktonic diatom and low planktonic/benthic ratio ～20and the lake returned to high level during 2330～930 cal.yr BP as inferred by there-dominance of the planktonic diatom and the high value of palnktonic/benthic ratio.The pollen-based climate reconstruction was also consolidated by the grain size andPediastrum concentration records.

Ugii Nuur湖周围现代孢粉研究表明：松属为空气传播的外来花粉，其含量变化可能指示了远山森林草原发育状况；禾本科具显著低代表性，母体植物建群时含量通常在10％以下：藜科花粉含量可以指示区域气候干旱程度。2、以现代孢粉研究为基础、可靠AMS~(14)C年代为框架，Ugii Nuur孢粉记录高分辨率地重建了蒙古国中部地区过去8660 cal.yr BP以来的植被和气候变化。8660～7800 cal.yr BP研究区植被为禾草草原，湖畔及河谷低地发育苔草草甸，远山发育松属针叶林和森林草原，气候温和略湿润；其中8350～8250 cal.yr BP湿生草甸扩张，旱生植物成分减少，气候凉湿。7800～6860 cal.yr BP旱生成分增加，气候转向暖干。6860～3170 cal.yrBP半荒漠草原扩张，远山森林草原退缩，山地草原和河谷及湖畔湿生草甸退缩，气候持续暖干。3170～2340 cal.yr BP半荒漠草原退缩，远山森林草原扩张，气候转凉变湿，末期湿度条件达最佳。2340～1600 cal.yr BP禾草草原发育，湖畔及河谷低地湿生草甸扩张，远山森林草原略有退缩，气候总体较凉湿。1600 cal.yr BP以来研究区发育禾草-冷蒿草原，气候波动较大。

In "A Modest Proposal", by suggesting that poor Irish parents sell their one-year-old babies to the rich English lords and ladies as food, Swift is making the most devastating protest against the inhuman exploitation and oppression of the Irish people by the English ruling class.

在《一个小小的建议》中，通过建议穷困的爱尔兰父母卖掉他们易碎的婴儿给富有的英国君主夫妇以此来换取食物，斯威夫特对由英国统治阶级对爱尔兰人进行非人道的剥削和压迫。

The thorium abundance ratio measured for the star in the Ursa Minor dwarf galaxy is as low as that found in the oldest stars in the Milky Way, suggesting that this star could be at least 12 billion years old.

钍丰度比测得的星在URSA患者小矮星系是低至那被发现在古老的恒星在银河系中，暗示这颗恒星可能至少有12亿年之久。

The system can be widely used in belt weighing and batching process control,etc.

介绍了基于智能模糊控制的嵌入式配料系统的设计方法，对模糊PID控制过程和系统调零作了重点的讨论，同时给出了PID控制的程序流程图和系统定长调零子程序。

"I dunno," she answered,"but if you show me aroun', I'll recognize it from the lighthouse just outside the porthole."

"我不知道，"她回答说，"如果你能带我转转，我能认出来的，因为灯塔就在舷窗外。"