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In this study, the genomic structure and regulatory elements of ApoD from 10 representive species including protozoan, invertebrate, protochordate and vertebrate were analyzed and compared. The genomic structure of ApoD is less conserved in organisms from protostome to deuterostome invertebrates, while it is highly conserved among chordates including amphioxus and verebrates. All four conserved cysteine residues are present in amino acid sequence of deuterostome ApoDs, while there are only two cysteine residues in amino acid sequence of protostomes ApoD. Structure divergence between protostome and deuterostome ApoD proteins suggests their function difference. The majority of regulatory elements are present in nearly all organism ApoD genes ranging from unicellular protozoan to mammals, suggesting that ApoD plays a very fundamental role, and possesses a conserved regulatory mechanism. However, there also exist some specific regulatory elements, which are present only in certain species and may perform some special roles.ApoD mRNA expression in murine NIH/3T3 fibroblasts exposed to various stresses such as as hydrogen peroxide and UV light shows dose-dependent increase. And a fly homolog of ApoD, Glial Lazarillo, whose overexpression results in increased resistance to hyperoxia as well as a extension of lifespan under normoxia and resistance to starvation without altering lipid or protein content.

本文首先从生物信息学角度对分属于原生动物、无脊椎动物、头索动物和脊椎动物类群的10种动物ApoD的基因结构及调控区的调控元件进行分析及比较,发现:(1)ApoD基因外显子-内含子结构从原生动物草履虫到原口动物再到后口动物海胆的进化过程中不保守,但在分析的几种脊椎动物中相当保守;(2)文昌鱼ApoD基因扮演从无脊椎动物到脊椎动物承上启下的角色,可能代表了脊椎动物ApoD基因原型;(3)四个半胱氨酸保守位点在后口动物中都存在,而在原口动物中只存在两个,原口、后口动物ApoD蛋白一级结构上的差异反映蛋白功能上可能也存在一定差别;(4)调控区大多数主要调控元件为不同动物共有,说明ApoD主要功能及其表达调控在进化中相当保守;(5)ApoD基因个别调控元件是随着物种进化而出现并开始发挥相关作用,如SF-1;还有一些调控元件在进化过程中还没有发现其规律,这说明ApoD某些功能和基因表达调控模式可能因物种不同而存在一定的差异。

Combining the specific hydrogeological structure and related parameters, the pumpage and its composition were calculated by a three-dimensional finite difference method.

结合具体的水文地质结构及有关参数,采用地下水流三维有限差分法计算了各渗流井的出水量及其组成。

Allogeneic and syngeneic fresh bone, autolyzed antigen-extracted bone, bone matrix gelatin, demineralized bone matrix were implanted into the muscle pouch of mice, at different times after implantation, the immunological, histological and alkaline phosphatase assay were conducted. The results revealed that all four kinds of allogeneic implants activated specific cellular and humoral immune responses, most notably in fresh bone group, the AAA, BMG and DBM inhibited the proliferation of the lymphocytes in vitro and BMG had the most powerful inhibiting action, allogeneic AAA, BMG and DBM might induce heterotopic osteogenesis in vivo, however, there were obvious difference in ALP and histomorphometry between allografts and isografts.

在小鼠肌肉内植入同种异体或同系新鲜骨、自消化抗原去除骨、骨基质明胶、脱钙骨基质,术后免疫学、碱性磷酸酶、组织学检查发现:4种同种异体植入物均可引发特异性细胞免疫反应和体液免疫反应,其中以新鲜骨移植引发的免疫反应最为显著;自消化抗原去除骨、骨基质明胶、脱钙骨基质在体外具有抑制淋巴细胞增殖的作用,骨基质明胶对淋巴细胞增殖的抑制作用最显著;同种异体与同系4种植入物在体内成骨活性有显著差异;自消化抗原去除骨、骨基质明胶、脱钙骨基质均有异位诱导成骨活性,其中骨基质明胶骨诱导活性最佳。

By way of parallel research method, the thesis studied the two s difference in culture attitude combining with specific text of elegies.

本文从平行研究的角度,结合具体中西悼亡诗文本,研究二者在文化观上的差异。

The specific latent heat is the difference in enthalpies of the substance in its two states.

比潜热是物质在两种状态下的焓差。下一篇:每天读一段,保持清醒哦

The specific latent heat is the difference in enthalpies of the substance in its two states.

题在哪里?怎么看不到/最好能发个WORD格式的东西,这样显得太乱了。

Then the finite difference method is employed to predict the thermal regime in asphalt pavement structures with a specific program. After itemizing the flaws in existing pavement temperature prediction theoretical methods, the boundary condition and the thermal parameters are confirmed.

然后通过对现有沥青路面温度场理论计算方法的详细分析,确定出了有限差分计算模型中的边界条件表达式以及材料热物理参数的合理取值范围。

All the aesthetic cultural activities are interpreted and analyzed from the angle of concealed code of ideology. A kind of cultural phenomenon iii a dominant position compared to other cultures simply comes down to the "supremacy" of ideology. The influence of commerce on art creation is simply equated with standardization and commonplace, which might make the difference between traditional and universal need and specific political need of contemporary capitalism mixed up, and might make the evolution of commercial culture neglected. Consequently, the inwardness of cultural phenomenon was misapprehended.

但意识形态批判理论在具体运用中有可能产生意识形态泛化的倾向,把所有的审美文化活动都从隐藏的意识形态编码角度进行解读和分析,把一种相对於其他文化处於更优势地位的文化现象简单归结为意识形态的&霸权&,把商业对艺术文化生产的影响简单地等同於标准化和平庸化,有可能混淆传统的或普适的需要与当代资本主义特定的政治需要之间的差别,忽视商业文化的演变,从而造成对文化现象内在性质的误解。

The climax of the presentation of the nature of sanctifying grace is found in its character as a participation in the Divine nature, which in a measure indicates its specific difference.

高潮介绍的性质sanctifying Grace是发现它的性质作为一个参与在神圣的性质,而这一项措施,也表明其具体差异。

However, because of difference between eastern and western culture, chinese people have their own affection experience and specific love types. then warps will appear when we try to use triangular theory to analyze china's love type.

然而,东西方文化的差异以及中国特殊的传统文化的存在,中国人具有自己独特的情感体验和爱情类型,使得我们在应用三元理论分析中国爱情的类型时出现偏差。

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推荐网络例句

We have something to do in the new stage.

在这段崭新的时期中,我们有一些要做的。

The difference between tourism decision-making under uncertainty and risky tourism decision-making is indistinctive.

其中不确定性旅游决策和风险旅游决策的界线比较模糊,两者的区分是相对的。

I will laud mine enemies and they will become friends; I will encourage my friends and they will become brothers.

我赞美敌人。敌人于是成为朋友;我鼓励朋友,朋友于是成为手足。我