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Similar results were observed as those of tissue array, showing that the expression of RIG-I was reduced significantly in HCC compared with that in para-tumor and normal liver tissue samples.

上述肝癌组织芯片免疫组化检测结果提示,在肝癌患者的癌旁组织中RIG-I蛋白广泛表达,且主要在核周胞质中分布,然而,在肝癌组织中RIG-I蛋白表达明显下调。

Decreased expression of RIG-I in human hepatocellular carcinomaFirst, with tissue array, we analyzed the expression of RIG-I in HCC, and found that 90%(27/30) of para-tumor samples were positive for RIG-I expression, but only 20%(6/30) of HCC samples were RIG-I positive.

然而,在30例肝癌患者的肝癌组织中,只有5例患者的癌组织中RIG-I蛋白表达为阳性,1例患者的癌组织中RIG-I蛋白表达为弱阳性,阳性率为20%。

Using the elutrap or dialyzer,we purified various RIG-Ⅰ/RNA complexes for crystallization.

使用elutrap和透析的方法,我们最终获得了不同的RIG-Ⅰ/RNA的复合物。

What is more, over-expression of RIG-I gene in A549 cells was found to reduce the pro- duction of newly produced West Nile virus.

同时,RIG-I的过表达能够抑制西尼罗病毒的增殖。

From the most dulcet tones to the hardest riffs, GUITAR RIG 2 is in a league of its own.

从最简单的音调,到最难的即兴演奏,都已结合到Guitar Rig 2里面了。

In our previous work, we found that RIG-G could interact with JAB1 and sequestrate the later in the cytoplasm, preventing JAB1 from facilitating the phosphorylated p27 nuclear export and degradation via the cytoplasmic ubiquitin/ proteasome pathway.

在以前的工作中,我们曾发现RIG-G可以与JAB1蛋白发生相互作用,并将后者阻滞在细胞浆中,无法正常携带磷酸化的p27蛋白出核,从而抑制了p27蛋白通过胞浆的泛素/蛋白酶体系统降解。

Elsewhere in the site I review SORD's MFF rig , pictured with this jacket.

在这个网址的其他地方, SORD's MFF rig 的链接,有这件外套的图片。

In the tenth and last book of the Rig Veda some new themes are explored, but the Dasyus are still condemned for being "riteless, void of sense, inhuman, keeping alien laws," and Indra still urges the heroes to slay the enemies; his hand is prompt to rend and burn, O hero thunder-armed: as thou with thy companions didst destroy the whole of Sushna's brood.

& ( Rig Veda X:22)在第十次和最后一本书的钻机吠陀一些新的主题进行了探索,但仍然Dasyus谴责为& riteless ,无效的意义上来说,是不人道的,使外来的法律,&和Indra仍敦促英雄来杀死敌人,他的&一方面是迅速向雷德和烧伤,噢英雄雷声武装:因为你与你的同伴didst摧毁整个Sushna的沉思。

In eukaryotic cells,Toll-like receptors in endosomal membrane were show to recognize viral RNA in endosome and thereby initiate innate immunity pathways for virus resistance.By contrast,a cytosolic RNA receptor protein, RIG-Ⅰ(retinoic acid inducible gene-Ⅰ),has recently been identified for recognition of the viral RNA.

在真核生物体内,除了定位于内吞体膜上的TOLL样受体能够识别入侵机体的病毒RNA,启动机体抗病毒的固有免疫反应外,近年来发现了另一种能够识别病毒RNA的细胞质内受体——RIG-Ⅰ。

RIG-I overexpression sensitizes hepatocellular carcinoma cells to the cell arrest and apoptosis induction by IFNalphaIn addition to the critical role in the antiviral response, IFNs can also regulate the immune response, induce cell growth inhibition and cell differentiation.

三、RIG-I增强肝癌细胞对干扰素免疫治疗敏感性的研究干扰素(Interferon, IFN)作为一种病毒抑制因子,不仅具有抗病毒作用,而且还具有免疫调节、抑制细胞增殖以及诱导细胞分化等作用。

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It is also known as one of the most poisonous naturally occurring substances.

它也被称为一个最自然发生的有毒物质。

The greatest stress is found at the location on the cross section where V is the largest.

最大应力出现在横截面上V为最大的地方。

It is the most important three water problem which our country faces in the 21st century that flood and waterlog, drought and shortage of water, the deterioration of water environment.

洪涝灾害、干旱缺水、水环境恶化是二十一世纪我国面临的三大水问题。