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The result of uroscopy of the proband was strong positive. There was a novel deletion mutation of c.876-877 del TC in the coding region of exon 6 of IDS gene, which was a hemizygous mutation. However, the mutation of his mother and sister was a heterozygous mutation. Detection of the exon 6 of IDS gene showed that the mutation was not found among normal controls and other patients with MPS I, IV, and VI other than MPS II. Homology comparison of amino acid sequences from different species showed that the phenylalanine glutamine of the mutation site of c.876-877 del TC located in p.292-293 was highly conserved. The activity of IDS enzyme of the proband was only 2.3 nmol/4 h/mL, which was much lower than normal; but the activity of IDS enzyme of his father, mother and sister was 641.9 nmol/4 h/mL, 95.8 nmol/4h/mL and 103.2 nmol/4h/mL, respectively.

结果显示:先证者尿检呈强阳性;其IDS基因exon 6编码区内存在c.876-877 del TC新缺失突变,为半合子突变,而其母、其姐为杂合突变;正常对照和其他非II型MPS患者的IDS基因exon 6的检测结果均未发现该突变;不同物种氨基酸序列的同源性比对显示: c.876-877 del TC突变所在的位置即p.292-293的苯丙氨酸谷氨酰胺高度保守;酶活性测定的结果显示:先证者的IDS酶活性仅为2.3 nmol/4 h/mL,大大低于正常值,而其父的为641.9 nmol/4 h/mL,其母的血浆酶活性为95.8 nmol/ 4h/mL,其姐的为103.2 nmol/4 h/mL。

TEPHEN DUKKER:"You think you've got your own computer all to yourself and you can't tell the difference that you're working on something other than a computer and sharing this other resource and doing it at a much lower cost than having your own PC."

tephen Dukker:你会认为你拥有了完全属于自己的电脑,你说不出有什么不同,感觉自己就是在用一台电脑,并用它分享这样那样的资源,这比拥有自己的个人电脑成本要低很多。

TEPHEN DUKKER:" You think you've got your own computer all to yourself and you can't tell the difference that you're working on something other than a computer and sharing this other resource and doing it at a much lower cost than having your own PC."

tephen Dukker:你以为你已有了自己的电脑,你说不出不同之处,你正在做的事与另一台电脑不同,共享其它资源,做这件事要比拥一台自己电脑的成本更低。

Plants and animals other than micro-organisms, and essentially biological processes for the production of plants other than nonbiological and microbiological processes.

除微生物之外的植物和动物,除非生物和微生物方法之外的主要是生物方法的培植植物的方法。

Evaluation Information does not include, however, information that is or becomes generally available to the public other than as a result of a disclosure by Buyer or its Representatives, was available to Buyer on a nonconfidential basis prior to its disclosure by Seller or its Representatives, becomes available to Buyer on a nonconfidential basis from a person, other than Seller or its Representatives, who is not known by Buyer to be otherwise bound by a confidentiality agreement with Seller or to be otherwise under an obligation to Seller not to transmit the information to Buyer, or was independently developed by Buyer without reference to the Evaluation Information.

评估信息不包括,然而,信息供给或变得一般公众除由于透露之外由买家或它的代表,供给买家根据一个没有争议的事物。依据在它的透露之前由卖家或它的代表,变得可利用对买家根据一个没有争议的事物。依据从人,除卖主之外或它的代表,由卖家不知道由一个机密协议否则一定以卖主或有义务否则对卖主不传送信息给买家,或由买家独立地开发了没有在评估信息的参考。

The three types of ink is the characteristic other than other than black and white color feature, that is, hue hue, saturation, brightness (Lightness, saturability.

油墨颜色的三种特征是除黑白以外的彩色特征,即色调、亮度、饱和度。

Any other adverse item of information, other than records of convictions of crimes which antedates the report by more than seven years.1

任何其他不利事项的信息,除定罪记录自报告之日起超过7年

Article 60 Any unit which, in violation of the provisions of paragraph 1 of Article 41 or paragraph 2 of Article 47 of this Law, intercepts the funds for purchasing agricultural products and misappropriates the funds to any use other than purchasing agricultural products, or intercepts the funds allocated for agriculture by people's governments at various levels and misappropriates such funds to any use other than agricultural expenditure, or intercepts the agricultural loans granted by banks and misappropriates such loans to any non-agricultural use, shall be ordered by organs at higher levels to return the funds intercepted or misappropriated within a time limit.

第六十条违反本法第四十一条第一款、第四十七条第二款的规定,任何单位将农产品收购资金截留、挪用于单位非农产品收购用途的,或者将各级人民政府拨付用于农业的资金截留、挪用于单位非农业开支的,或者将银行的农业贷款截留、挪用的资金;情节严重的,由上级机关或者所在单位给予直接责任人员行政处分。

Article 60 Any unit which, in violation of the provisions of paragraph 1 of Article 41 or paragraph 2 of Article 47 of this Law, intercepts the funds for purchasing agricultural products and misappropriates the funds to any use other than purchasing agricultural products, or intercepts the funds allocated for agriculture by people's governments at various levels and misappropriates such funds to any use other than agricultural expenditure, or intercepts the agricultural loans granted by banks and misappropriates such loans to any non-agricultural use, shall be ordered by organs at higher levels to return the funds intercepted or misappropriated within a time limit.

第六十条违反本法第四十一条第一款、第四十七条第二款的规定,任何单位将农产品收购资金截留、挪用于单位非农产品收购用途的,或者将各级人民政府拨付用于农业的资金截留、挪用于单位非农业开支的,或者将银行的农业贷款裁留、挪用于单位非农业用途的,由上级机关责令限期归还被截留、挪用的资金

Article 60 Any unit which, in violation of the provisions of paragraph 1 of Article 41 or paragraph 2 of Article 47 of this Law, intercepts the funds for purchasing agricultural products and misappropriates the funds to any use other than purchasing agricultural products, or intercepts the funds allocated for agriculture by people's governments at various levels and misappropriates such funds to any use other than agricultural expenditure, or intercepts the agricultural loans granted by banks and misappropriates such loans to any non-agricultural use, shall be ordered by organs at higher levels to return the funds intercepted or misappropriated within a time limit.

第六十条违反本法第四十一条第一款、第四十七条第二款的规定,任何单位将农产品收购资金截留、挪用于单位非农产品收购用途的,或者将各级人民政府拨付用于农业的资金截留、挪用于单位非农业开支的,或者将银行的农业贷款裁留、挪用于单位非农业用途的,由上级机关责令限期归还被截留、挪用的资金;情节严重的,由上级机关或者所在单位给予直接责任人员行政处分。

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从有历史以来,英国,在此地早期居住的是凯尔特人,已经被征服了三次。

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