查询词典 mutation pressure

The basic of laboratory is for measuring and testing pressure. The main equipments of the lab. are I,II grade piston type pressure vacuometer(Difinity:±0.02%,Test range:0.25Mpa-60Mpa),Digital pressure meter,Test system and microwave tube of dynamic pressure sensor, Intelligent digital pressure verifier.The test for micropressure, low pressure, middle pressure and high pressure can be worked out.

本实验室主要进行压力的计量和测试工作，主要设备有一，二等活塞式压力真空计（准确度：± 0.02%，测量范围： 0.25Mpa— 60Mpa）；数字式压力计；动态压力传感器的标定激波管和测试系统；以及智能数字压力校验仪等仪器；可进行微压，低压，中压以及高压测试实验。

"Hydraulic safety valve" is widely used in hydraulic power systems and hydraulic equipment of safety devices, pressure devices can be limited, is a special valve, which is different from the conventional valve, the traditional use of mechanical valves metal spring as a driving force, can only be limited to low pressure, encountered more BALANCING VALVES than 10Mpa pressure limit pressure can do to increase the volume of pressurized design, the traditional role of the high-pressure valves and high pressure hydraulic power systems and hydraulic equipment The limit pressure of necessity is bulky and complicated structure, difficult to manufacture large, high production costs; in the course of the fatigue of metal spring parameters change fluctuating pressure limiting Ambassador to regular revision to ensure the normal use.

&气动液压安全阀&是目前广泛应用于液压动力系统和液压设备中的安全装置，也可以作限压装置，是一种特殊的阀门，它不同于传统的阀门，传统阀门用机械金属弹簧为动力，只能限中低压力，遇到超过10Mpa以上的压力限压，闸阀只能做加大体积的增压设计，因此传统阀门作用于高压和超高压的液压动力系统和液压设备的限压时必然体积笨重，结构复杂，制造难度大，产品成本高；在使用过程中金属弹簧的疲劳变化大使限压参数波动大，要经常调整才能保证正常使用。

"Hydraulic safety valve" is now widely used in hydraulic power systems and hydraulic equipment in the safety device could also serve as limited pressure device, is a special valve, unlike conventional valves, conventional valves with mechanical metal spring as a driving force, can only be limited to low pressure, the pressure encountered over more than 10Mpa limit pressure can do to increase the volume of the Safety Overflow Valve booster design, the traditional role of the high-pressure valves and high pressure hydraulic power systems and hydraulic equipment The limit pressure of necessity is bulky and complicated structure, difficult to manufacture large, high production costs; in the course of the fatigue of metal spring parameters change fluctuating pressure limiting Ambassador to regular revision to ensure the normal use.

&气动液压安全阀&是目前广泛应用于液压动力系统和液压设备中的安全装置，也可以作限压装置，是一种特殊的阀门，它不同于传统的阀门，传统阀门用机械金属弹簧为动力，只能限中低压力，遇到超过10Mpa以上的压力限压，只能做加大体积的增压设计，因此传统阀门作用于高压和超高压的液压动力系统和液压设备的限压时必然体积笨重，结构复杂，制造难度大，产品成本高；在使用过程中金属弹簧的疲劳变化大使限压参数波动大，要经常调整才能保证正常使用。

Measurirg indxes included:(1) Electrocardiograh;(2) Hemodynamics: cardiac output, pump output, aortic pressire, pulmo nary artery pressure, left atrium pressure, right atrium pressure, left ventricular end systolic pressure, left ventricular end diastolic pressure, LV-dp/dt, right ventricul ar end systolic pressure, RV-dp/dt, systolic pressure time index, diastolic pressure time index, endocardial viability ratio;(3) Myocardial metabolism: coronory sinus blood flow, myocardial oxygen consumption, myocardial lactate extractiorn;(4) Ischemic myocardial area;(5) Ultrastructure of myocardium.

测量指标包括：①心电图；②血流动力学：心输出量、泵输出量、主动脉压、肺动脉压、左房压、右房压、左室收缩末压、左室舒张末压、左室压的一阶导数、右室收缩末压、右室压的一阶导数、收缩压力时间指标、舒张压力时间指标、心内膜下心肌供血比率；③心肌代谢；冠状窦血流量、心肌氧耗量、心肌乳酸摄取量；④心肌缺血面积检查及缺血心肌的超微结构观察。

①Location of WD gene in Ch inese: Using pairwise linkage analysis and multipoint linkage analysis method, w e constructed a genetic map of DNA markers within D13q14.2-3 which refined the location of WD gene by restriction fragment length polymorphism and microsatellite polymorphism analysis;②Screen for mutations of WD gene in Chinese people: we detected the structure of 21 exons of WD ge ne in 45 patients from 39 pedigrees by PCR-SSCP(Single strand conformation poly morphism) and PCR-DNA sequencing technology, found a new mutation in exon 5 and nuclcotide sequence analysis showed it is a T insertion. We also conformed the Arg778Leu in exon 8, the highest frequence mutation point in Chinese people, wit h mutation rate 22.8%in total;③Carrier detection and presymptomatic diagnosi s of WD: Based on DNA recombination technology, we peformed successfully the gen e diagnosis in all individuals of 79 families with WD and built up a helpful spe cific enzyme cut method (PCR-Msp1) to detect the carrier and presympomatic patients in Chinese pe ople with WD.

①WD的基因定位研究：通过RFLP及微卫星多态性分析，应用两位点及多位点连锁软件，建立了中国人WD基因在D13q14.2-3区域的精细遗传连锁图谱，从而首次对中国人WD基因进行了精确定位；②WD基因突变研究：应用PCR-SSCP及DNA测序技术，对39个家系45名WD患者进行该致病基因的21个外显子突变筛选，发现WD基因5号外显子存在新的T插入突变，并证实中国人WD基因的突变热点为8号外显子，突变形式为Arg778Leu，其频率为22.8%；③WD的症状前诊断和杂合子检出：应用DNA重组技术对79个家系进行基因诊断，成功地进行了WD的症状前诊断和杂合子检出，并建立了WD的基因筛选的PCR-Msp 1酶切方法。

Results as bellows: AtSIRT1 was located in Mitochondrial as hSIRT4 of human, and maybe take part in respiration and electron transformation chain, AtSIRT2 was located in nucleolus as hSIRT6 of human, maybe play important role in extend lifespan;mutation in AtSIRT1 leaded to cotyledon of plant turn to yellow and caused short life span. Mutation in AtSIRT2 could make the color of leaf turn to purple and accumulate a lot of anthocyanin;Sirtinol, a inhibitor of SIRT which did not cause the same model of the mutation of AtSIRT1 and AtSIRT2 indicated that the mechanism of Sirtinol was different from other organism;the structure of AtSIRT1 and AtSIRT2 were similar to other known Sir2, which indicated that they maybe have the same function;AtSIRT2 was overexpressed and its activity was detected.

结果表明，1，拟南芥AtSIRT1与人的同源蛋白hSIRT4相同，定位于线粒体，可能参与呼吸作用和电子传递，SIRT2与人的同源蛋白hSIRT6相同，定位于细胞核，可能同它的功能类似，在延缓衰老及调节细胞寿命方面起作用。2，AtSIRT1突变，可引起幼苗和植株的子叶变黄和早衰；AtSIRT2突变，可引起叶片发紫，沉积大量花青素。3，SIRT蛋白的抑制剂Sirtinol不能表型模写AtSIRT1和AtSIRT2突变体，说明Sirtinol在拟南芥中的作用机制不同于其他生物。4，AtSIRT1和AtSIRT2蛋白质结构预测表明与已知的Sir2蛋白相似，揭示其功能的相似性。5，在大肠杆菌中过量表达了其中一个基因(AtSIRT2)，可体外检测其酶学活性，进一步证明其功能。

In Small Tail Han sheep, Chinese Merino sheep, Corriedale sheep and South African Mutton Merino sheep, frequency of AA genotype was 0.58, 0.98, 0.96, 1.00, frequency of AB genotype was 0.40, 0.02, 0.04, 0.00, frequency of BB genotype was 0.02, 0.00, 0.00, 0.00, respectively. The ewes with mutation homozygous genotype BB or mutation heterozygous genotype AB had 1.45 at 305 bp of exon 3 of BMP4 gene in the BB genotype in comparison to the AA genotype, and this mutation resulted in an amino acid change: alanine—?aspartic acid. The ewes with genotype BB had 0.61 P

结果表明：小尾寒羊、中国美利奴绵羊、考力代绵羊在INHA基因5'调控区发生了1处碱基突变(316C→T)，南非肉用美利奴绵羊没有发生这种突变；小尾寒羊、中国美利奴绵羊、考力代绵羊、南非肉用美利奴绵羊AA基因型频率分别为0.58、0.98、0.96、1.00，AB基因型频率分别为0.40、0.02、0.04、0.00，BB基因型频率分别为0.02、0.00、0.00、0.00；突变纯合型和突变杂合型小尾寒羊平均产羔数分别比野生型多1.45只P

In this paper, a mathematical description of mutation operator and a concept of mutation function for the study of evolutionary programming and evolution strategies are proposed, and several methods and examples of constructing mutation operator with uniformly distributed random variables are presented.

进化算法是研究全局优化算法中最重要的随机算法之一，本文给出了进化规划和进化策略的变异算子的数学描述，并提出变异函数的概念，在此基础上，给出了用均匀分布的随机数构造变异算子的几种方法和若干例子。

Until now, about 600 types of FBN1 gene mutation have been reported, in which missense mutation and splice site mutation are mainly associated with ectopia lends.

至今已经发现约600种类型的FBN1基因的突变形式，其中与晶状体脱位相关的以错义突变和剪接位点突变为主。

Mutation rate at exon of GH in five bovine species was very low with the percentage of 3.48%. The majority of nucleotide substitution was nonsense mutation and only one missense mutation was observed. Molecule tree based on haplotypes of bGH at exon 5 showed that differentiation was apparent relatively between Bubalus bubalis and Bos taurus, Bos indicus, Bos grunniens, Bos frontalis. There was no apparent differentiation among other four bovine species and they shared mutual ancestral sequence.

序列分析表明，5个牛种GH基因外显子5的遗传变异水平较低，平均核苷酸变异率约为3.48%，而且绝大多数位点的核苷酸替换是同义突变，仅发现1个错义突变位点；从GH基因外显子5序列单倍型构建的分子进化树来看，水牛与普通牛、瘤牛、牦牛及大额牛的分化相对比较明显，其他4个牛种之间并无明显分化，还享有共同的祖先序列。

A historical region of southwest France between the Pyrenees and the Garonne River. The duchy of Aquitaine was joined with France after the marriage of Eleanor of Aquitaine to King Louis VII in1137, but its possession was disputed after her subsequent marriage to Henry II of England.

阿基坦法国西南部一个历史地区，位于比利牛斯山和加隆河之间，在1137年阿基坦的埃莉诺与国王路易斯七世结婚之后阿基坦公国加入法国，但当她再嫁英国亨利二世后，其归属权便受到争议

There are moments when I look at the smiling , happy faces of my expectant staff and wonder how they will cope when confronted by an outraged housemaster along with an unrepentant and recalcitrant bleached blond teenager in 18 years ' time .

有时候，我看着那些满怀期待的员工微笑，幸福的脸，想着当他们遇到一位愤怒的宿舍管理员和一位不知悔改，叛逆，而且将头发染成白色的18岁少年时，他们会如何处理。