查询词典 knock out

In heat shock protein gp96-peptide complexes induced tumor rejection model,antigen specific CD8T cells adoptively transffered into perforin knock out mice failed to proliferate and differentiate into CTLs whereas co-transfer of wide type NK cells rescued the clonal expansion and CTL differentiation of transferred CDST cells.These results suggested important immuno-modulatory roles of perforin and presumably different roles of perforin secreted by NK cells versus by CD8~+ CTLs.

例如，在热休克蛋白Gp96-肽复合体所诱导的抗肿瘤免疫应答中，穿孔素基因敲除小鼠中单独回输的野生型CD8T细胞不能产生有效的抗肿瘤免疫应答，而同时回输野生型NK细胞能够恢复CTL应答。

For myself, I'm battening the hatches and staying in doors - just praying that the massive amounts of ice and snow hitting the ill-equipped city don't knock out electricity and in turn my only sources of heat, entertainment and work.

我则把自己封在屋子里面，祈祷着这个有着糟糕防备的城市的电力不要被大量的冰雪破坏，否则将会断掉我唯一的暖气来源，以及我的娱乐和工作。

One was the pqsA' positive expression plasmid constructed by cloning the pqsA'-lacZ fusion digested from pYHP441 into miniCTX-1, whose sequence was then integrated into wild type PAO-1 chromosome by biparental mating procedure. The other was pqsA-E operon knock-out plasmid whose sequence between pqsD and pqsE operon was inserted by tetracycline cassette by the site specific insertion mutagenesis strategy and the mutant constructed by biparental mating of S17-1 that harbored the plasmid and pqsA' positive expression mutant.

一种是酶切质粒pYHP441获得pqsA'-lacZ片段后，亚克隆入质粒miniCTX-1中，构建成PqsA'的阳性表达质粒，随后将构建的质粒，通过双亲交配过程整合入野生型铜绿假单胞菌株PAO-1染色体组中；另一种是通过点特异插入诱变策略，将四环素基因盒插入启动子pqsD和pqsE之间，构建的阴性质粒转化入大肠杆菌S17-1株后，和上述pqsA'阳性表达突变株进行双亲交配过程。

Acremonium. However, low frequency of integrative genetic transformation is a major obstacle to gene cloning in Cephalosporium acremonium, for example, screening and identification of genes from a DNA bank by complementation of blocked mutants, knock out or replacement of genes.

过去的一些研究表明质粒对顶头孢霉的转化率太低，限制了许多分子生物学技术的应用，如利用互补突变株从顶头孢霉的DNA文库筛选和鉴别基因、基因敲除或者基因替换。

In.particular, genes involving in histidine biosynthesis (hisJ、 hisG、 hisF、 hisH、 hisB and hisD) were significantly repressed in mutant strain, while other 5 genes such as fur-, ftn-, dps, yecl and bcp which related to iron homeostasis were up-regulated. In addition, after hns gene was knock-out, expression of sjh but not stpA, which encodes H-NS paralogues, increased significantly.

比较特别的是，6个参与组氨酸合成与代谢的基因hisJ、hisG、hisF、hisH、hisB以及hisD在突变体表达下调，而与铁代谢有关的5个基因fur、ftn、dps、yecI和bcp的表达明显上调。

Leif: I came across a beauty today. She is a knock-out.

雷夫：我今天碰上个美女，她美得让人倾倒。

Pentaphyllum is a traditional printed fabric with knock-out version of lessive with printing, commonly known as "" drug anatkina cloth, is about 1,300-year history.

蓝印花布是传统的镂空版白浆防染印花，俗称&药斑布&，距今已有一千三百年历史。

A 1-0 win at Debrecen was not enough to keep Rafa Benitez's men in the competition as Fiorentina beat Olympique Lyonnais to go through to the knock-out phase at the Merseysiders' expense.

1比0击败德布勒森并不足以让贝尼特斯的球队留在欧冠比赛中，由于佛罗伦萨击败了里昂使得其取代默西塞德人进入了淘汰赛。

It was reported that OP-1 was responsible for the induction of nephrogenic mesenchyme during the development of embryonic kidney. Absence of OP1 would lead to kidney dysplasia. With OP-1 gene knock-out, nude mice died of renal failure within the first 24 hours after birth.

研究发现，OP-1在胚胎肾脏发育期间与肾原性间充质的诱导有关，其缺乏导致肾脏发育不良，OP-1基因敲除突变型的裸鼠在出生后24小时内死于肾功能衰竭。

The results showed that in skin trauma and combined radiation-impaired wound models, CGS21680 (agonist of the A2A recaptor) promoted while A2A gene knock-out delayed the course of skin wound healing.

结果表明，CGS21680促进外周组织伤口的愈合，却加重颅脑创伤模型的神经功能损害，这与其促进谷氨酸释放有关。

Methods: Five patients with parkinsonism or dystonia were assigned to general anesthesia using an modified endotracheal tube.

本实验依照人体实验之相关规定进行，五位患有帕金森氏症或肌张力异常的病人接受神经立体定位手术。

If you can benefit from this book, it is our honour.

如果您能从本书获益，这将是我们的荣幸。