查询词典 inhibitors

Dialectic retinopathy,the most common microvascular complication of diabetes is the leading cause of blindness.Many drugs have been used to prevent the development of it.The primary drug treatment includes the intensive control of blood glucose,blood pressure and the reducing ofblood-fat. The directed against drug treatment includes advanced glycation end products inhibitor, vascular endothelial growth factor inhibitor,inhibitive factor promoter,supplement of inosital, aldose reductase , protein kinase C inhibitors, GH inhibitors,improvement of retinal microcirculation, DAG-PKC inhibitor, ginkgo blibe extract, antioxidant.

糖尿病视网膜病变是最常见的糖尿病微血管病变，目前有很多致力于延缓糖尿病视网膜病变的药物研究，包括严格控制血糖、血压，降低血脂的基础药物治疗，以及蛋白非酶糖基化终末产物抑制剂、血管内皮生长因子抑制剂和抑制因子促进剂、肌醇的补充及醛糖还原酶抑制剂的应用，及蛋白激酶C抑制剂、生长激素抑制素、改善视网膜微循环药物、DAG-PKC抑制剂、银杏叶提取物、抗氧化剂等针对性药物的应用。

Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上两种重要疾病和研究组方向，本论文工作开展了多个肿瘤细胞株和碳酸酐酶Ⅱ靶标模型的建立和筛选工作，累计筛选1万多个/次样品，发现10余个活性较强化合物；从粗提取物筛选结果中选取两种抗肿瘤活性强的菊科植物水朝阳旋覆花(Inula helianthus-aquatica)和三角叶凤毛菊进行了系统化学和活性成分研究，分离鉴定了58个化合物，发现6个新化合物和14个抗肿瘤活性化合物；通过合作对水朝阳旋覆花中活性较强的bigelovin进行了抗肿瘤作用机制研究，发现它可能是通过降低G2期重要的转录因子E2F-1，致使细胞周期阻滞在G0/G1期，引起多发性骨髓瘤U266细胞凋亡；开展了7个新的天然酚类CAⅡ抑制剂的对接研究和61个合成的系列磺酰胺类CAⅡ抑制剂的3D-QSAR分析，结果表明计算与实验一致。

The book features chapters that explain the challenges of high sequence diversity in the viral envelope gene for the development and use of entry inhibitors, the clinical utility of virus phenotyping, the development of this class of inhibitors as microbicidal therapy, and the success story of enfuvirtide from the bench to FDA approval.

解释高顺序差异在病毒信封基因给发展和进入抑制剂的使用内的挑战的书特徵章，病毒phenotyping的临床的效用

Fie years after initiation of treatment, 79% patients were still on renin-angiotensin inhibitors, 65% on -blockers, 56% on spironolactone, and 83% on statins. Notably, multiple drug treatment and increased seerity of heart failure was associated with persistence of treatment. Nonpersistence with renin-angiotensin inhibitors,-blockers, and statins was associated with increased mortality with hazard ratios for death of 1.37 (95% CI, 1.31 to 1.42), 1.25 (95% CI, 1.19 to 1.32), 1.88 (95% CI, 1.67 to 2.12), respectiely.

开始治疗5年后，有79％病人继续使用肾素血管紧张素抑制剂，65％用阻滞剂，56％用安体舒通，83％使用他汀类，值得注意的是，联合用药和心衰的加重同坚持治疗相关，无法坚持使用肾素血管紧张素抑制剂，阻滞剂，安体舒通，他汀类药物的病人同增加的死亡率相关，其死亡危险比分别为1.37 (95%可信区间， 1.31 － 1.42)， 1.25 (95%可信区间， 1.19 － 1.32)， 1.88 (95%可信区间， 1.67 － 2.12)，。

Expression rate induced by thrombin was 50.88% and PAC?1 re?expression was 54.55%. It is concluded that the ability of recovered lyophilized platelets added with reversible activation?inhibitors, DMSO and trehalose to aggregate and coagulate has showed no significant difference as compared with FPRP. The reversible activation?inhibitors can decrease CD62p expression of lyophilized platelets, and may enhance their survival ability and prolongate survival time. Therefore the efficiency of lyophilizing platelets can be improved based on this freeze?drying procedure.

添加血小板可逆性激活抑制剂，海藻糖和DMSO后的冻干血小板，其聚集活性和促凝血功能与新鲜血小板无明显差异，血小板可逆性激活抑制剂降低了冻干血小板的CD62p表达，增强了冻干血小板的生存能力，因而延长了其生存时间，因此可以该冻干方法为基础进一步提高冻干保存血小板的效率。

In this thesis, the advantages and disadvantages of potentiodynamic polarization curve, electrochemical impedance spectroscope and coulostatic method for studying corrosion inhibitors in acidic mediums were compared. And then the effect of three popular acid corrosion inhibitors such as thiourea, dodecylamine and propargyl alcohol on the corrosion inhibition behaviors of Q235 steel in acidic solutions were investigated by these techniques. The anodic desorption behavior and extreme value phenomenon of concentration were surveyed thoroughly as well.

本文讨论了动电位极化曲线、电化学阻抗谱和恒电量测量方法在酸性介质缓蚀剂研究中的优势和不足，在此基础上，研究了硫脲、十二胺和丙炔醇等三种常见酸性介质缓蚀剂对Q235钢在酸性溶液中的缓蚀行为和机理，并深入探讨了缓蚀剂的阳极脱附和浓度极值现象。

The sulfamate moiety in the structure of topiramate is chemically related to known CA inhibitors, and in fact, topiramate inhibits CA activity. To further explore the pharmacological action of topiramate, and clarify the possibility of anti-tumor growth and metastasis of CA inhibitors and its relation with AQP1, we studied the effect of topiramate on adhesion of high metastatic prostate carcinoma to laminin, and established the spontaneous metastatic model of Lewis lung carcinoma to studied the influences of topiramate on tumor growth and metastasis and AQP1 expression in lungs and primary tumors of mice.

为了深入研究托吡酯的药理作用，阐明CA抑制剂和水通道蛋白AQP1相互作用影响肿瘤生长和转移的可能性及其机制，我们研究了托吡酯对高转移的前列腺癌细胞粘附于基质成分层粘连蛋白的影响；以Lewis肺癌自发性转移为模型，考察了托吡酯对肿瘤生长和转移的影响；同时观察了托吡酯对荷瘤小鼠肺组织及原发瘤组织AQP1表达的影响；检测了其对血管新生的作用；利用体外AQP1表达模型，研究了CA抑制剂对AQP1功能的影响；此外，用蛋白质组学的关键技术，通过对模型组与托吡酯治疗组血清蛋白质组的比较分析，来寻找与肿瘤转移相关的蛋白质，探索托吡酯的可能作用靶点。

Results indicate that the two types of tetrazole derivative inhibitors have good corrosion inhibition ability for copper in NaHCO3 solution, and they are both anode-type inhibitors.

合成了胍基四唑和1-苯基－5-巯基－1， 2， 3， 4-四氮唑2种缓蚀剂，用失重法和电化学法研究了2种缓蚀剂在5% NaHCO3碱性介质中对铜的缓蚀性能和吸附行为。

Acrylic resin as coated material, N- thiophosphric triamide and dicyandiamde as biological inhibitors, with Fluid Bed spraying biological inhibitors on urea granular surface and coated it with acrylic resin afterward, four coated urea fertilizers were made for monitoring slow/controlled effects of coated fertilizers in distilled water.

采用丙烯酸树脂为包膜材料，以NBPT和DCD为生化抑制剂，利用流化床对尿素进行涂层生化抑制剂及包膜，制备4种包膜肥料，对这些包膜肥料在水中的控释效果进行了研究。

Acrylic resin as coated material, N- thiophosphric triamide and dmyandlamde as biological inhibitors, with Fluid Bed spraying biological inhibitors on urea granular surface and coated it with acrylic resin afterward, four coated urea fertilizers were made for monitoring slow/controlled effects of coated fertilizers in distilled water.

采用丙烯酸树脂为包膜材料，以NBPT和DCD为生化抑制剂，利用流化床对尿素进行涂层生化抑制剂及包膜，制备4种包膜肥料，对这些包膜肥料在水中的控释效果进行了研究。

Cynanchum Lingtai apricot production in the average weight 65 grams, the brightly-colored fruit, juicy rich, sweet-sour taste, sweet from the nucleolus, when the late Qing Dynasty famous Shaanxi, Gansu provinces, the Qing imperial court Tongzhi tribute for years.

灵台生产的牛心杏平均单果重65克，果实色泽鲜艳，汁多味浓，甜酸适口，离核仁甜，清末时就驰名陕、甘两省，清同治年间曾为朝廷贡品。

Chenopodium album,Solanum nigrum, and Amaranthus retroflexus were very susceptible to the herbicides. Polygonum persicaria and Abutilon theophrasti were relatively less susceptible to the herbicides, and Lycopersicon esculentum was not susceptible to it. The relationship between reduction rates of weed biomass and PPM values of weed leaves 2,4, and 6 days after treatment was established.

供试的6种杂草对该混剂的敏感性存在显著差异：红心藜Chenopodium album、龙葵Solanum nigrum和反枝苋Amaranthus retroflexus对该混剂最敏感，ED90值分别为47.65、71.67和29.17g/hm2；春蓼Polygonum persicaria和苘麻Abutilon theophrasti敏感，ED90值分别为96.91、114.20g/hm2；而番茄不敏感。