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Cardiac hypertrophy is one of adaptive responses of the heart to a variety of pathological stimuli, including hypertension, myocardial infarction, congenital heart disease, heart valvula disease, and perturbations in sarcomeric function due to altered expression or mutations of contractile proteins. Increase in wall tension and hormonal stimuli are thought to directly activate various membrane-bound receptors and signal transduction cascade within cardiomyocytes resulting in the activation of immediate early genes and responsive genes such as c-jun, c-fos, c-myc, egr-1, ANF, BNP. Then the expression of construction proteins such as MLC-1, skeletal α-actin was unregulated.

中文题名hhlim基因的表达调节及其与心肌细胞肥大发生之间的关系副题名外文题名 hhlim gene expression regulation and its role in development of cardiomyocyte hypertrophy 论文作者郑斌导师温进坤韩梅学科专业生物化学与分子生物学研究领域\研究方向学位级别博士学位授予单位河北医科大学学位授予日期2003 论文页码总数106页关键词心肌细胞肥大基因表达心肌肥厚 hhlim基因馆藏号BSLW /2003 /R542.2 /33 心肌细胞肥大是高血压、心脏瓣膜病、急性心肌梗塞及先天性心脏病等临床常见疾病的一种并发症，是心肌细胞对多种病理刺激的一种适应性反应。

If a variable declaration includes an expression but not an explicit type, the static type of the variable is inferred from the static type of the expression.

如果变量声明中包含一个不是显式类型的表达式，变量的静态类型将通过表达式的静态类型来推断。

OBJECTIVE: To clone mice CTGF gene and construct its eukaryotic expression vector, in addition, to investigate its transient expression in VSMC.

目的：克隆小鼠结缔组织生长因子基因、构建其真核表达载体，并在血管平滑肌细胞中瞬时表达。

Methods: The coding region of superoxide dismutase was amplified using PCR method from the E.co1i genome. The PCR product was cloned into PUC19-T vector and sequenced. In addition, the cloned coding region of Mn-SOD was inserted into the expression vector PET-28a to form the recombinant plasmid PET-28a-Mn-SOD and was then transformed into E.coli BL21 for expression.

用PCR方法从大肠杆菌2号基因组中扩增Mn-SOD基因编码区，克隆到pUCm-T Vector，测定核苷酸序列；再将基因编码区克隆到原核表达载体PET-28a，构建含Mn-SOD基因的重组表达质粒，转化到大肠杆菌BL21中进行IPTG诱导表达。

objective to study gastrodia elata blume to effect tau protein,sod,mda expression in gyrus hippocampi and cerebral cortex of experimental mice.methods to inject okadaic acid to mice ventriculus lateralis and to measure tau protein level,sod activity and lipid superoxide mda content of sod control group,oa injection group,oa and gastiodia elata injection solution group.results tau protein of experimental group(p＜0.05/p＞0.05),sod was lower than model group(p＜0.001) and was higher than control group(p＜0.05).conclusion gastrodia elata blume can increase sod activity and reduce tau protein expression and superoxide lipid forming in brain tissue of experimental dementia mice caused by oa.it can prevent and treat ad.

目的 观察天麻对痴呆模型大鼠海马、皮质神经元微管相关蛋白、超氧化物歧化酶和脂质过氧化物丙二醛表达的影响，探讨其治疗阿尔茨海默病(alzheimer disease，ad)的作用机制。方法用冈田酸(okadaic acid，oa)注射大鼠侧脑室造模，测定模型组、实验组、对照组海马和皮质tau蛋白、sod、mda的含量。结果实验组tau蛋白低于模型组(p＜0.001)，高于对照组(p＜0.05)；sod高于模型组(p＜0.001)和对照组(p＜0.05)；mda低于模型组(p＜0.001)，高于对照组(p＜0.05)。结论天麻可增强oa致实验性痴呆大鼠脑组织sod活性，降低mda蓄积和tau蛋白生成，具有防治阿尔茨海默病的作用。

Objective To detect the expression of β-NGF, p75NTR and hair follicle stem cell specific markers in vibrissa hair follicle of rat embryo. Methods Using frozen section and immunohistochemistry to detect the expression of β-NGF and p75NTR.

目的 研究胚胎大鼠触须毛囊隆突区β-神经生长因子、p75神经营养因子受体(p75NTR)与毛囊干细胞特异标志物的表达规律。

With the development of GTD malignancy, the normal expression rates of E cad and the strong expression rates of LN declined gradually and were significantly different from those of normal villus.

随着GTD恶性程度的增加，E cad的正常表达率及LN的强表达率逐渐降低，且与正常绒毛组织有显著差异。

The invention discloses a pyruvate oxidase gene derived from viridian aerococcus, recombinant expression plasmid constructed by the gene and an engineering strain of escherichia coli gene transformed by the recombinant expression plasmid.

本发明公开了一种绿色气球菌来源的丙酮酸氧化酶基因AvPyOD，该基因所构建的重组表达质粒，以及该重组表达质粒转化的大肠杆菌基因工程菌株。

Calligraphy uses lines as the main expression of visual arts, and image expression is its main characteristic.

书法作为以线条为主要表达方式的造型艺术，意象表达是其主要特征。

This paper systematically researched this sort of nonuniformly sampled signals'digital spectrum structure, signal-to-noise ratio , the response of D/A converter with nonuniformly sampled signals, the algorithm for estimating timing offsets, the relationship between the discrete time expression of the total energy and the continuous time expression, the estimation of the average power, the algorithm of recovery and application in designing and analyzing the digital waveform synthesizer.

本文全面系统地研究了这类周期性非均匀采样信号的数字谱结构，信噪比表达式，数模转换器对非均匀采样信号输入的响应，误差校正算法，时域与频域的能量对应关系，对功率测量的影响，内插恢复算法，以及在设计和分析数字波形合成器中的应用。

"Second Life is remarkably easy to work with, and is very popular,"

"第二次生命是显着容易的工作，并且很受欢迎，"

For example, we usually assume that materials are homogeneous and isotropic and free of internal defects or flaws.

为了得到适合有限元分析的模型，我们必须经过如图2所示的简化步骤。