查询词典 estradiol

Comparison the in vivo activity of 90％EtOH fraction and compound 21 with estradiol, indicated the 90％EtOH fraction behaved the stronger activity on total mineral content, total density, trabecular mineral content, trabecular density and the anti-twist strength of the proximal tibia in OVX rat than estradiol, but compound 21 displayed the weaker activity on total mineral content, total mineral density, trabecular mineral density, cortical mineral content, cortical mineral density, cortical thickness and the anti-twist strength of the proximal tibia than estradiol.

通过90％乙醇部位及化合物21都与阳性对照药雌二醇的纵向比较后，在大鼠OVX模型中，90％乙醇部位高剂量组在提高全骨的骨矿含量和骨密度、松质骨的骨矿含量和骨密度及骨的抗扭力方面，作用强于阳性对照组雌激素类化合物，化合物21在小鼠OVX模型中，抑制了全骨的骨矿含量、骨密度和全骨断面面积的降低，松质骨骨密度的降低，皮质骨的外膜周长的增长，皮质骨骨矿含量量、皮质骨厚度和皮质骨密度的下降及抗扭力的减弱。

Objective To observe the effect of estradiol on contractile activity of small intestine smooth muscles isolated from rabbits.

目的：观察雌二醇（estradiol，E2）对家兔离体小肠平滑肌收缩活动的影响。

Alkylphenols are applied widely as the rubber additives surfactants in domestic and industrial products, antioxidants and so on. As it's decomposer, nonylphenol has a steady chemical characteristics and exist widely in environment. As it's molecule structures are similar as 17beta-estradiol in human body, and it can combine with estradiol receptor simulating it, disrupt endocrine system and induce health damage effect. Many studies on environmental endocrine disrupting chemicals approved that NP have weaken estradiol functions.

烷基酚被广泛用作塑料增塑剂、农药乳化剂、纺织行业的整理剂等，作为其降解产物壬基酚(nonylphenol，NP)的化学性质稳定，环境分布广泛，由于其分子结构与人体内雌二醇的分子结构相似，许多环境内分泌干扰的实验研究结果证实壬基酚具有雌激素样作用，可以模拟雌激素与体内雌激素受体结合，干扰机体的内分泌代谢，导致健康危害效应。

Result At the end of dioestrus, the estradiol level was increased gradually, and the peak of estradiol appeared from 1 day before oestrus to 3 days after oestrus (52.50±29.26) pg/mL, then the estradiol decreased rapidly, its lowest value at 6-9 days of oestrus (7.20±5.50) pg/mL. The level of progesterone was low before oestrus, and rose gradually at the peak of estradiol and reached the highest value at 9-15 days of oestrus (35.52±7.87) ng/mL, then it decreased gradually.

结果 发情间期的末期，雌二醇开始升高，在发情前1 d至发情开始后3 d内出现雌二醇高峰(52.50±29.26) pg/mL，峰值后雌二醇急剧下降，到发情第6~9天下降至最低值(7.20±5.50) pg/mL；孕酮水平在发情前期较低，于雌二醇高峰时开始上升，发情第9~15天达到最高值(35.52±7.87) ng/mL，此后逐渐下降。

Objective To investigate the immunological function of estradiol in vitro.

目的 研究雌二醇（Estradiol，E）对大鼠腹腔巨噬细胞的免疫作用机制。

Methods Estradiol-randomly methylated β-cyclodextrin (E2-RAMEB) solution, and 70% ethanol solution of estradiol and estradiol nasal spray in 3 different doses 0.16、0.48、1.60 mgkg^(-1 were nasally administrated to rats, respectively. Non-compartment statistical moment method was used in pharmacokinetics study.

对大鼠鼻腔给予雌二醇-随机甲基化β-环糊精包合物的生理盐水溶液、雌二醇乙醇溶液和3种剂量的雌二醇鼻腔喷雾剂，用非隔室模型统计矩法进行了药物动力学研究，并与静脉注射雌二醇相比较计算绝对生物利用度。

The conclusions were as follows: theνO-H andνC=O IR absorption maxima shifted towards higher wave numbers after imprinting 17β-estradiol on TFMAA-co-TRIM copolymer with the red shift of theνO-H groups being apparent after precipitation polymerization for 16h while that forνC=O groups being observed after polymerization for 24h. A strong interaction between TFMAA and 17β-estradiol was confirmed by the high selectivity for 17β-estradiol, as indicted by the values of the separation factor of isomers of 17β-estradiol/17α-estradiol (2.28) and the imprinted factor (3.01). Particle diameter of TFMAA-co-TRIM polymer was between 300 nm and 1.5μm, which suited well for solid phase sorbent throughout at low column pressure. The recognition of imprinting TFMAA-co-TRIM polymer for sterol molecules was driven by enthalpy eluted with acetronitile, and low temperature was in favor of the separation of sterol structure analogues on imprinting column. TFMAA-co-TRIM polymer possessed of determinate anti-heat stability, with melting point beginning at 255.84℃, Tp=257.40℃, control TFMAA-co-TRIM polymer and imprinting TFMAA-co-TRIM polymer were respectively decompounded at 267.79℃and 343.11℃, and solid micro-extraction noddle prepared by the special polymerization also showed definite recognition for 17β-estradiol by GC/MS detecting at 270℃. By selection of various washing and elution solvents, elution reagents of close polymerization system were of more advantage in template molecules retention and recognition on molecularly imprinted solid phase extraction column. At a certain extent, progesterone, 17α-estradiol, 17β-estradiol and 4-androstene-3, 17-dione could be intercepted on the MISPE column. Especially, MISPE had high selectivity for progesterone, and imprinting TFMAA-co-TRIM polymer could achieve adsorption balance within 50 min by absorption kinetics test for 17β-estradiol. However, MISPE column showed better selectivity and enrichment property for 17β-estradiol than C18 and CSPE columns according to the data from HPLC and GC/MS analyses. Recovery of 17β-estradiol on MISPE column was up to 85.5% while when prime extracting solution of milk powder was sampled, the recovery of CSPE and C18 columns were 43.7% and 30.7%, respectively.

通过研究阐明：紫外聚合产物TFMAA-co-TRIM中的νO-H振动吸收峰在聚合16h后红移，νC=O振动吸收峰在聚合24h后红移；TFMAA-co-TRIM对雌二醇异构体的印迹因子达到了3.01，α为2.28，优于其它功能单体参与得到的聚合物识别特性；TFMAA-co-TRIM聚合物粒径介于300 nm至1.5μm之间，作为色谱固定相具有良好的通量和低的柱压；在乙腈流动相中，TFMAA-co-TRIM分子印迹固定相的分离过程主要被焓驱动，低温有利于分子印迹固定相分离甾醇结构类似物；TFMAA-co-TRIM分子印迹聚合物在255.84℃时开始熔融，Tp=257.40℃，聚合物CP的降解温度在267.79℃，MIP降解温度在343.11℃，制备的固相微萃取头初步经GC/MS 270℃的耐热性测定；不同的洗提溶剂筛选证明了选择接近聚合溶剂的洗脱体系更有利于MISPE发挥识别效应；分子印迹固相萃取柱对孕酮、17α-雌二醇、17β-雌二醇和雄烯二酮都具有不同程度的保留特性，可作为此类化合物的吸附材料，特别对孕酮强保留的富集特性，可作为孕酮的选择性识别吸附剂，其分子印迹聚合物对17β-雌二醇的吸附动力学测定显示在50 min内基本达到吸附平衡，具有作为传感器核心敏感材料的潜力；对比萃取奶粉中17β-雌二醇性能，MISPE柱比非分子印迹固相萃取柱和C18柱具有更高的保留，回收率依次为85.5%，43.7%和30.7%。

Results: The proportional volume, numerical density of the granules in ovariotomy group were less than those in sham-ovariotomy and ovariotomy estradiol groups (P.001); the proportional volume and numerical density of ASG in myocardial cells almost came back to the normal level with small dose estradiol; along with the enhancement of estradiol dosage, the content of ASG in myocardial cells was more than those in sham-ovariotomy and small dose estradiol group (P.01), and showed a quantity-efficiency relation.

结果：切除大鼠双侧卵巢后，心房特殊颗粒的体密度和数密度与对照组及用雌二醇组比较明显减少(P＜0.01)，小剂量雌二醇可使大鼠心肌细胞心房特殊颗粒的体密度和数密度恢复到正常水平，随剂量增加，心肌细胞心房特殊颗粒的量也伴随增加，呈量效关系。

Forty adult female rats were divided randomly into 4 groups:① Pseudo-operation control group: no ovariotomy, no common carotid artery occlusion;② Cerebral ischemia reperfusion group: with CCAO only, no OE;③ Ovariotomized control group: with OE and CCAO, no estradiol;④ Estradiol supplement group: with OE, CCAO and estradiol supplemented (30 d after ovariotomy, estradiol was supplemented every day for 14 d). All the rats were sacrificed after 12h of reperfusion injury, 10% of brain tissue was homogenized and 10% alue was determined by UV spectrophotometer, NO content was detected, and frozen sections and NOSmRNA in-situ hybridization were performed.

取SD大鼠40只随机分为4组：①假手术对照组：不切除卵巢，不夹闭颈总动脉；②脑缺血再灌注组：作局灶性脑缺血再灌注手术，不切除卵巢；③去卵巢对照组：切除卵巢，作局灶性脑缺血再灌注手术，不补充雌激素；④补充雌激素组：切除卵巢，作局灶性脑缺血再灌注手术，补充雌激素（切除双侧卵巢30d开始补充雌激素，连续2周）。

The objective of this study was to identify how many different forms of GnRH in the black porgy brain by HPLC and to localize GnRH fiber and soma in the brain by immunohistochemistry. In addition, we also study the effects of 17- estradiol on the hypothalamic gonadotropin-releasing hormone soma number in the black porgy.

本实验希望藉由HPLC来测定黑鲷脑中GnRH的种类，并利用免疫染色的方法，了解GnRH神经元在黑鲷脑中的分布，并探讨雌二醇(17β-estradiol； E2)对切除性腺(gonadoectomy； GNX)的黑鲷脑中下视丘部位GnRH神经细胞本体个数之影响。

Cynanchum Lingtai apricot production in the average weight 65 grams, the brightly-colored fruit, juicy rich, sweet-sour taste, sweet from the nucleolus, when the late Qing Dynasty famous Shaanxi, Gansu provinces, the Qing imperial court Tongzhi tribute for years.

灵台生产的牛心杏平均单果重65克，果实色泽鲜艳，汁多味浓，甜酸适口，离核仁甜，清末时就驰名陕、甘两省，清同治年间曾为朝廷贡品。

Chenopodium album,Solanum nigrum, and Amaranthus retroflexus were very susceptible to the herbicides. Polygonum persicaria and Abutilon theophrasti were relatively less susceptible to the herbicides, and Lycopersicon esculentum was not susceptible to it. The relationship between reduction rates of weed biomass and PPM values of weed leaves 2,4, and 6 days after treatment was established.

供试的6种杂草对该混剂的敏感性存在显著差异：红心藜Chenopodium album、龙葵Solanum nigrum和反枝苋Amaranthus retroflexus对该混剂最敏感，ED90值分别为47.65、71.67和29.17g/hm2；春蓼Polygonum persicaria和苘麻Abutilon theophrasti敏感，ED90值分别为96.91、114.20g/hm2；而番茄不敏感。