查询词典 downstream

After selecting a highly potent strain of poxvirus that was able to traffic to tumors when administered intravenously to mice the authors engineered the virus such that it would target only specific cancer cells -- those with increased expression of a protein known as E2F and/or activation of signaling downstream of a protein known as EGFR.

以毒攻毒：设计病毒，攻击肿瘤一种新的治疗癌症的方法正在开发中：用病毒感染肿瘤杀死癌细胞留下正常细胞不被伤害。这些病毒以病毒疗法而著称。在一项新的研究当中，David Kirn 和他在旧金山Jennerex生物疗法同事已经描述出利用新病毒疗法后老鼠和兔子抗肿瘤效应的发展。在选择高度特异性痘状病毒后才能有效的到达肿瘤生长地方，然后通过静脉途径给老鼠。

These results suggested that the function of each function domain in HIV 1 LTR exhibited distinct characteristics on gag gene expression in vaccinia virus:(1) The function of intact LTR on gag gene expression varied with the upstream poxvirus promoter;(2) NR sequence neither decreased nor increased the Gag protein exprssion level;(3) Enhancer sequence might not be recognized by recombinant vaccinia virus expression system;(4) TAR sequence enhanced Gag protein expression effectively;(5) U5 region and its downstream non translated sequence had little effect on

免疫印迹和免疫酶试验检测均表明，6株重组病毒的Gag蛋白表达量因LTR不同而有明显差异，表明HIV1的LTR及其下游基因置于痘病毒启动子控制下，在痘苗病毒中表达时有下述特点：（1）不同的痘苗病毒启动子与全长LTR相互作用，对gag基因表达有显著不同的调控效果；（2）NR序列对Gag蛋白表达没有明显影响；（3）EN序列不能被重组痘苗病毒表达系统识别；（4）TAR序列可提高Gag蛋白的表达量；（5）U5区及下游非翻译序列不影响Gag蛋白的表达。

Our results indicate that the RNA species may be regulated by PKC downstream signals related to the MAP kinase cascade. We observed E1 contains RNA increase in the polysome after induction of U937 differentiation.

我们分别对两者进行研究，发现含有Exon N1的Chk1 transcript可能以直接或间接的方式受p53的抑制；而含有Exon 1的Chk1 transcript的调控机制较不清楚，仅知可能是由PKC下游的讯息传递所调控，且可能和MAP kinase cascade有所关联。

Recent studies have shown that interaction parters can modulate the transcription activity of AP-2 over the downstream targets.

最近很多研究表明与AP-2相互作用的蛋白能够调节AP-2对下游基因的转录活性。

Downstream, paddlers will mix river camping with village stays in traditional rammed-earth homes.

到达下游，涉水者们将在河边露营或者在用传统方法筑成的乡村房屋中住宿。

Besides characterisation of the two genes' function, RT-PCR, Northern analysis, primer extension, and lacZ reporter gene fusions were also tried in this study to investigate the genetic organization of the operons related and their transcription regulation, map gene was found to locate at the end of a long ribosome protein genes operon and yflG is in another operon with its downstream gene.

除了对这两个基因的功能鉴定，本文还阐明了它们各自所在操纵子的遗传结构，并采用RT-PCR、Northern印迹及引物延伸等多种方法，最终分别对它们的启动子进行了定位。

Transcribed sequence just downstream of the trp operon promoter that is central to the attenuation mechanism.

紧接在trp操纵子的启动子之后转录出来的序列，对衰减作用机理很重要。

Attenuator Transcribed sequence just downstream of the trp operon promoter that is central to the attenuation mechanism.

衰减子 紧接在 trp 操纵子的启动子之后转录出来的序列，对衰减作用机理很重要。

The article fully introduces the current situation of development and usage of downstream products of DSD Acidg intermediates which are OBA,Direct Dyes,Acid Dyes,and Active Dyes.

DSD酸及合成DSD酸过程中的中间过渡产物NTS酸、DNS酸和DNS酸单还原的产物ANSD酸，这四种化合物统称DSD酸系列中间体，它们是重要的有机化工原料。

The release height and downstream distance have been normalised using Hb.

释放高度和下游的距离已经正常化使用血红蛋白。

Who? I never heard of him, Paul said, before asking teammate James Posey if he had heard of him.

赛后，科比说，他一直都是一名非常出色的射手，今天他打得很棒。

When I joined the company, I rotated around the different sections.

我加入这个公司时，轮换过几个不同的部门。