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The experiments reveal that solvent outflow is controlled by the system's viscosity while non-solvent inflow is controlled by the hydrophile of the interface.

实验表明,溶剂外扩散受控于体系的粘度,非溶剂的向内扩散受控于界面的亲水性。

The relevant controlling measures are selection of proper bacterial species for lower higher alcohols formation; inoculative use level(1.3~1.5)×107/ml;α-aminonitrogen in malt liquid should be controlled 165~185mg/L, pH value 5.2~5.6; oxygen dissolution 8~10mg/L; the temperature controlled below 12℃; and proper fermentation degree.

控制方法主要有:选择高级醇生成量较低的菌种,接种量控制在(1.3~1.5)×10 7个/ml;麦汁中α-氨基氮控制在165~185mg/L,pH在5.2~5.6,溶解氧在8~10mg/L;主酵温度控制在12℃以下,控制适当的发酵度。

Pumping Systems—HPLC pumping systems deliver metered amounts of mobile phase from the solvent reservoirs to the column through high-pressure tubing and fittings. Modern systems consist of one or more computer-controlled metering pumps that can be programmed to vary the ratio of mobile phase components, as is required for gradient chromatography, or to mix isocratic mobile phases (i.e., mobile phases having a fixed ratio of solvents). However, the proportion of ingredients in premixed isocratic mobile phases can be more accurately controlled than in those delivered by most pumping systems. Operating pressures up to 5000 psi or higher, with delivery rates up to about 10 mL per minute are typical.

泵系统—HPLC 泵系统通过高压管路和设备将储液系统的流动相按设定的流量精确地输送通过柱子,最新的泵系统由一台或更多的计算机测量控制泵使得流动相组分能够按照程序变化改变比例,如有必要,可以进行梯度洗脱或混合均匀的流动相(i.e。,流动相可以是混合比例的溶液),然而,当操作压力达到或高于5000 psi,流速达到10ml/min的典型值时,预混合均匀的流动相各成分的比例就比泵控制的更精确。

The former is necessary for equilibrium-controlled synthesis of peptide bonds while the latter is necessary for kinetically controlled synthesis of peptide bonds.

酰胺酶活性起水解或合成肽键的作用,因而对平衡控制的肽键合成是必需的;酯酶活性起转移酰基的作用,因而对动力学控制的肽键合成是必需的。

Type II is more kinetically controlled, while type I is thermodynamically controlled.

加热条件下,四方形空穴结构可以完全转化成烷基链对插的结构。

No entire nitrendipine crystals were observed visually in SEM photos. The results of X-ray diffraction and differential scanning calorimetry analysis indicated that the crystalline form of nitrendipine was highly dispersed in microspheres, so as amorphous state. The drug release rate of microspheres could be controlled with adjusting the ratio of solid dispersion carriers and retarding agents formulated. The agitation speed and temperature of the preparation process have distinct effect on micromeritic properties of microspheres. The release profiles of the microspheres were mainly affected by the stirring rate of paddle, the concentration of SDS and pH of dissolution medium. Cooling speed and time, however, have no evident influence on the drug release rate of the microspheres. The dissolution data showed that the mechanism of drug release from microsphers was mainly diffusion-controlled. The incorporation efficiencies of 3 batches sample were exceed 96. 8%, which implied that the current method was suitable for design sustained-release dosage form for poorly water-soluble drug.

在扫描电子显微镜下观察,在微球内外未发现尼群地平的完整结晶,X-射线粉末衍射和差示扫描量热试验结果也显示,尼群地平已经被高度分散在微球中;微球的释药速度可通过调整处方中固体分散体载体和阻滞剂的比例控制;制备温度和搅拌速度对微球的质量影响较大;溶出仪的搅拌速度,释放介质的浓度和pH对微球的释放有较大的影响;制备过程中的冷却速度和冷却时间对微球的释放行为影响不很明显;方程拟合的结果表明缓释微球的释药行为符合扩散机制;测定三批微球样品的包封率均在96.8%以上,表明该法适合于制备难溶性药物的缓释微球。

Methods eighty patients with ish were randomized into therapeutic group and controlled group. controlled group received amlodipine 5 mg/d,indapamide 2.5 mg/d; therapeutic group received amlodipine 5 mg/d,indapamid 2.5 mg/d,combined with sustained release isosorbide 5 mononitrate 40 mg/d for 4 weeks.

80例ish患者随机分为对照组39例和治疗组41例,对照组给予氨氯地平5 mg,吲达帕安2.5 mg每日1次口服,治疗组在上述治疗的基础上给予5-单硝异山梨酯缓释剂40 mg每日1次口服,疗程4周。

Both the myoelectric controlled stimulation and hyperbaromeric oxygenation were applied in the treatment group, while the control group used the myoelectric controlled stimulation only.

治疗组采用肌电控制刺激训练和高压氧相结合的方法进行治疗,对照组仅用肌电控制刺激训练治疗。

Osmotically controlled oral drug delivery systemsutilize osmotic pressure for controlled delivery of active agents.

中文摘要:口服渗透泵控释给药系统作为目前最理想的控释技术之一,具有释药均匀恒速、不受体内环境影响、适应范围广等特点。

The buckling failure measured includes: the relationship between controlled cyclic curvature and ovalization at buckling, and the relationship between the controlled cyclic curvature and the number of cycles to produce buckling.

力学行为包含有:弯矩-曲度的关系及椭圆化-曲度的关系,而皱曲损坏包含有:控制循环曲度-到达皱曲椭圆化的关系及控制循环曲度-循环至皱曲圈数的关系。

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