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No entire nitrendipine crystals were observed visually in SEM photos. The results of X-ray diffraction and differential scanning calorimetry analysis indicated that the crystalline form of nitrendipine was highly dispersed in microspheres, so as amorphous state. The drug release rate of microspheres could be controlled with adjusting the ratio of solid dispersion carriers and retarding agents formulated. The agitation speed and temperature of the preparation process have distinct effect on micromeritic properties of microspheres. The release profiles of the microspheres were mainly affected by the stirring rate of paddle, the concentration of SDS and pH of dissolution medium. Cooling speed and time, however, have no evident influence on the drug release rate of the microspheres. The dissolution data showed that the mechanism of drug release from microsphers was mainly diffusion-controlled. The incorporation efficiencies of 3 batches sample were exceed 96. 8%, which implied that the current method was suitable for design sustained-release dosage form for poorly water-soluble drug.

在扫描电子显微镜下观察,在微球内外未发现尼群地平的完整结晶,X-射线粉末衍射和差示扫描量热试验结果也显示,尼群地平已经被高度分散在微球中;微球的释药速度可通过调整处方中固体分散体载体和阻滞剂的比例控制;制备温度和搅拌速度对微球的质量影响较大;溶出仪的搅拌速度,释放介质的浓度和pH对微球的释放有较大的影响;制备过程中的冷却速度和冷却时间对微球的释放行为影响不很明显;方程拟合的结果表明缓释微球的释药行为符合扩散机制;测定三批微球样品的包封率均在96.8%以上,表明该法适合于制备难溶性药物的缓释微球。

The soft release mechanism in a controlled hold-down and release system proposed recently was discussed in this paper and a finite element and rigid-body mixed model was put forward to analyze its release characteristic during launch vehicle liftoff.

以一种新提出的新型强制式牵制释放系统为例,建立了分析运载火箭缓释放过程中缓释特性的有限元—刚体混合模型。

The results showed that:(1) The drug micropellet with reasonable drug entrapment ratio and release velocity would be obtained if the amountof crosslinking agent and drugs was controlled successfully;(2) The Ibuprofen micropellet had a suitable release rate in artificial intestinal juice but it was a very low release rate in artificial succus gastrius because it had a low solubility in acid medium.

以环氧氯丙烷为交联剂,羟丙基壳聚糖为载体,将布洛芬做成缓释控释药物微丸,讨论了包埋条件对微丸性能的影响以及药物在人工胃液和人工肠液中的释放行为。结果表明:(1)合理控制交联剂用量和药物投入量,能够得到药物包封率和释放性能良好的药物微丸;(2)布洛芬药物微丸在人

The production of crop specific controlled release BB fertilizer is simple and easy to do by mixing different nutrient-lapsed time fertilizers according the different nutrient demand ratio of crops,it should be the developing direction of compound fertilizer in China.

分析了树脂和硫磺包裹尿素缓释肥料发展缓慢的原因和弊端,提出以水溶性聚合物作为尿素和复混肥料的包膜胶结和内质缓释剂,具有降解快对作物无害改善土壤结构成本低等特点,将促进缓释肥料的发展采用生产不同时间段释放养分的缓释肥,按作物不同生育期对养分的需求比例掺混在一起,生产作物专用的缓/控释BB肥料简单易行,应是我国缓/控释肥料的发展方向

Joint stent and the use of microcoils is the treatment of intracranial wide-necked aneurysms safe and effective method, LEO stent dedicated intracranial self-expandable stent, To meet the intracranial vascular The tortuous road design, A stent in place easily, positioning accuracy can be controlled release merits.

LEO颅内专用自膨式支架,专为适应颅内迂曲血管经路设计,具有支架到位容易、定位准确、可控制释放优点,使支架辅助栓塞颅内宽颈动脉瘤更加安全、有效。

So starch can be used as degradable materials for controlled-release of agrochemicals .

基于淀粉的这些优点,可用来作控制农药释放的降解基材。

So starch can be used as degradable materials for controlled-release of agrochemicals .

本文主要研究以淀粉为基材的降解材料的配方及其缓释性质。

Therefore, a commercial polymer-coated controlled-release fertilizer with Chinese-owned needs a long time study, especially in the theory research and market development.

因此,推出具有中国独立知识产权的商品化聚合物包膜肥料要求加强理论基础研究,并加快产业化进程。

Oxalic acid loading substantially stimulated soil P release from A1 horizon, showing a linear relationship; but its effect on B horizon soil was relatively negligible, especially at low oxalic acid concentrations mmol L^(-1. Oxalate solutions 0.5~20.0 mmol L^(-1 oxalic acid adjusted to pH 5.16 with 10.0 mmol L^(-1) NaOH had a much higher (1.51~2.98 times) soil-P-release effect than oxalic acid solution the same in oxalate concentration. Therefore, the mechanism of oxalic acid/oxalate triggering release of soil phosphorus is assumed to be dominated by ligand-exchange or complexing reactions of oxalate anionC2O(superscript 2- subscript 4 but not simply acid-dissolving effect. The effect of oxalate anion on soil phosphorus release was found to be somewhat cumulative, i.e. the amount of P released was primarily controlled by the cumulative oxalate loading rate, relatively independent of the manner of oxalate addition (one-time or sequential).

结果表明,草酸能显著促进暗棕壤A层磷的释放,土壤磷溶出量随草酸溶液浓度升高而线性增加;但对B层土壤磷的释放效应相对较弱,草酸浓度低於5mmolL^(-1)时B层磷的释放不明显。pH5.16草酸钠溶液比相同浓度的草酸溶液具有更高的解磷效率,在设置二者浓度为0.5~20.0mmolL^(-1)时,前者的解磷量是后者的1.51~2.98倍,推断草酸盐溶液或凋落物淋洗液中草酸类物质促进暗棕壤磷释放的主要机理在於草酸阴离子C2O(上标 2-下标 4配位反应。

BACKGROUND: Based on documents abroad and home, both alginic acid and carbomer are used to prepare gel matrix of lithium carbonate tablets; furthermore, hydroxypropyl methyl cellulose, a kind of water-soluble skeletal material, can be used as controlled release matrix of lithium carbonate tablets.

摘要背景:目前国内外文献报道的碳酸锂缓释片多采用海藻酸、卡波姆等制备凝胶型骨架片,同样作为水溶性骨架材料的羟丙基甲基纤维素,也可作为碳酸锂的缓释基质。

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