查询词典 conformation

The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle，CP)和两个19S调节颗粒(regulatory particle，RP)组成的ATP(adenosine-triphosphate，ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心，它是由4个圆环堆叠形成的桶状复合物，其中两侧外环每个环是由α_1-α_7亚基组成，两个内环每个环是由β_1-β_7亚基组成，4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔，其内壁为催化活性位点所在地；外侧α环中心的孔道是底物到达催化中心空腔的通道，一般被α亚基上的N末端所封闭，阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

At last, in term of the before-mentioned basic steps of generated algorithm, the computer conformation of general J-M fractal images is realized using the Visual C++ programming, and large numbers of fractal images are obtained.

最后，文章根据所得出的生成算法基本步骤，通过Visual C++编程实现了广义J-M分形图的计算机生成，同时生成了大量的实验图形。

But for the biliverdin, it adopt a near planar and cyclic helical conformation on the silver colloid.

而胆绿素则是采取平面的环状螺旋结构平躺吸附于银胶表面。

Therefore, the aim of docking is to find the conformation with the lowest binding free energy.

分子对接包含两个方面，一是快速有效的搜索算法，可以在可能的空间进行构象搜索；另一个是好的打分函数，能够在合理的时间内正确有效地从搜索到的结构中区分出近天然构象。

For example, the growth initial condition selects the conformation of binormal zinc oxide helix, though the normal configuration is also stable only from the aspect of energy.

例如，我们发现如果初始生长条件选择了binormal型的氧化锌纳米螺旋带，尽管从能量的角度来说，normal型的氧化锌纳米螺旋带也可以稳定存在的，那么最后生长的为binormal型的氧化锌纳米螺旋带。

Since the Border Terrier is a working terrier of a size to go to ground and able, within reason, to follow a horse, his conformation should be such that he be ideally built to do his job.

由于边境梗是一种用于野外工作的工作梗，比如追踪马匹等，所以他被培养出乐于完成自己工作的天性。

The conformation of Ap is related to molecular weight, branched degree and external chain length.

支链淀粉的构象与其分子量、分支度、外链长和淀粉浓度有关。

①Location of WD gene in Ch inese: Using pairwise linkage analysis and multipoint linkage analysis method, w e constructed a genetic map of DNA markers within D13q14.2-3 which refined the location of WD gene by restriction fragment length polymorphism and microsatellite polymorphism analysis;②Screen for mutations of WD gene in Chinese people: we detected the structure of 21 exons of WD ge ne in 45 patients from 39 pedigrees by PCR-SSCP(Single strand conformation poly morphism) and PCR-DNA sequencing technology, found a new mutation in exon 5 and nuclcotide sequence analysis showed it is a T insertion. We also conformed the Arg778Leu in exon 8, the highest frequence mutation point in Chinese people, wit h mutation rate 22.8%in total;③Carrier detection and presymptomatic diagnosi s of WD: Based on DNA recombination technology, we peformed successfully the gen e diagnosis in all individuals of 79 families with WD and built up a helpful spe cific enzyme cut method (PCR-Msp1) to detect the carrier and presympomatic patients in Chinese pe ople with WD.

①WD的基因定位研究：通过RFLP及微卫星多态性分析，应用两位点及多位点连锁软件，建立了中国人WD基因在D13q14.2-3区域的精细遗传连锁图谱，从而首次对中国人WD基因进行了精确定位；②WD基因突变研究：应用PCR-SSCP及DNA测序技术，对39个家系45名WD患者进行该致病基因的21个外显子突变筛选，发现WD基因5号外显子存在新的T插入突变，并证实中国人WD基因的突变热点为8号外显子，突变形式为Arg778Leu，其频率为22.8%；③WD的症状前诊断和杂合子检出：应用DNA重组技术对79个家系进行基因诊断，成功地进行了WD的症状前诊断和杂合子检出，并建立了WD的基因筛选的PCR-Msp 1酶切方法。

Purpose: Studied the effects of static magnetic fields on vitro catalase｀s conformation and activity.

目的研究了强稳恒磁场对离体牛肝过氧化氢酶构象及活力的影响。

It was found that the change of surface potential of the purple membrane resulting from acetylation induced the change of local protein conformation Which could be delocalized all over the protein to a great extent and affected the nature of binding sites of retinal and the structure of the retinal chromophore.

结果表明：酰化引起的表面电位的改变诱导了蛋白局部构象的改变。这种改变在很大程度上离域到整个蛋白分子中而影响了视黄醛结合位点的性质及生色团的结构，从而导致可观察的光谱变化。

What are your goals and strategies for growth?

你的成长目标和策略是什么？

And unto the angel of the church in Sardis write; These things saith he that hath the seven irits of God, and the seven star I know thy works, that thou hast a name that thou livest, and art dead.

3：1 你要写信给撒狄教会的使者，说，那有神的七灵和七星的，说，我知道你的行为，按名你是活的，其实是死的。